New flu prevention shot shows promise in large trial

NCT ID NCT06609460

Completed Prevention Sponsor: Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new medicine called CD388, given as a single set of three shots, to see if it can prevent the flu in healthy adults aged 18 to 64. Over 5,000 participants received either CD388 or a placebo. Researchers measured how many people got the flu over the next 24 weeks and checked for side effects. The goal is to find a dose that works well and is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CD388 (a long-acting antiviral injection)
What this could lead to: If successful, this could provide a new option for preventing influenza with a single dose lasting several months.
What could go wrong: This is a phase 2b trial, so it is still early. The drug may not prove effective or could have side effects. Results may not apply to people at high risk for flu complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA

Contacts and locations

Locations

Acclaim Clinical Research

San Diego, California, 92120, United States
Alliance for Multispecialty Research, LLC

Fort Myers, Florida, 33912, United States
Alliance for Multispecialty Research, LLC

Layton, Utah, 84041, United States
Baptist Health Center for Clinical Research

Little Rock, Arkansas, 72205, United States
Catalina Research Institute, LLC

Montclair, California, 91763, United States
Clinical Research Partners, LLC

Richmond, Virginia, 23226, United States
Clinical Site Partners, LLC dba Flourish Research

Miami, Florida, 33186, United States
Clinical Trials of Texas, LLC dba Flourish Research

San Antonio, Texas, 78229, United States
Critical Care, Pulmonary & Sleep Associates, PLLP/CCT Research

Lakewood, Colorado, 80228, United States
Cullman Clinical Trials

Cullman, Alabama, 35055, United States
Del Sol Research Management, LLC

Tucson, Arizona, 85715, United States
DelRicht Research

Atlanta, Georgia, 30329, United States
DelRicht Research

Louisville, Kentucky, 40205, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research

Prairieville, Louisiana, 70769, United States
DelRicht Research

Gulfport, Mississippi, 39503, United States
DelRicht Research

Springfield, Missouri, 65807, United States
DelRicht Research

Charlotte, North Carolina, 28205, United States
DelRicht Research

Tulsa, Oklahoma, 74133, United States
DelRicht Research

Charleston, South Carolina, 29407, United States
DelRicht Research

Hendersonville, Tennessee, 37075, United States
DelRicht Research

Prosper, Texas, 75078, United States
Fiel Family and Sports Medicine/CCT Research

Tempe, Arizona, 85283, United States
Floridian Clinical Research

Miami Lakes, Florida, 33016, United States
Health Awareness, LLC

Jupiter, Florida, 33458, United States
Healthcare Clinical Data, Inc.

North Miami, Florida, 33161, United States
IMA Clinical Research

Monroe, Louisiana, 71201, United States
IMA Clinical Research

New York, New York, 10036, United States
Johnson County Clin-Trials

Lenexa, Kansas, 66219, United States
Lonestar Clinical Research, LLC

Dallas, Texas, 75243, United States
Lynn Institute of the Rockies

Colorado Springs, Colorado, 80918, United States
Nature Coast Clinical Research

Inverness, Florida, 34452, United States
Optimal Research, LLC

Peoria, Illinois, 61614, United States
Pinnacle Research Group, LLC

Anniston, Alabama, 36207, United States
Profound Research LLC

Oceanside, California, 92058, United States
Profound Research LLC

Clarkston, Michigan, 48346, United States
Profound Research LLC

Farmington Hills, Michigan, 48334, United States
Profound Research LLC

Rochester Hills, Michigan, 48307, United States
South Florida Research Center, Inc.

Miami, Florida, 33135, United States
Spartanburg Medical Research

Spartanburg, South Carolina, 29303, United States
Stephenville Medical & Surgical Clinic

Stephenville, Texas, 76401, United States
Sundance Clinical Research, LLC

St Louis, Missouri, 63141, United States
Velocity Clinical Research - Albuquerque

Albuquerque, New Mexico, 87107, United States
Velocity Clinical Research - Anderson

Anderson, South Carolina, 29621, United States
Velocity Clinical Research - Boise

Meridian, Idaho, 83642, United States
Velocity Clinical Research - Cleveland

Beachwood, Ohio, 44122, United States
Velocity Clinical Research - Huntington Park

Huntington Park, California, 90255, United States
Velocity Clinical Research - Medford

Medford, Oregon, 97504, United States
Velocity Clinical Research - Norfolk

Norfolk, Nebraska, 68701, United States
Velocity Clinical Research - Omaha

Omaha, Nebraska, 68134, United States
Velocity Clinical Research - Salt Lake City

West Jordan, Utah, 84088, United States
Velocity Clinical Research - San Diego

La Mesa, California, 91942, United States
Velocity Clinical Research - Sioux City

Sioux City, Iowa, 51106, United States
Velocity Clinical Research - Springdale

Cincinnati, Ohio, 45246, United States
Velocity Clinical Research - Valparaiso

Valparaiso, Indiana, 46383, United States
Zenos Clinical Research

Dallas, Texas, 75230, United States
hVIVO

London, E1 1EQ, United Kingdom

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