Engineered immune cells take on muscle disease
NCT ID NCT06154252
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 9 times
Summary
This study tests a one-time treatment called CABA-201, made from a patient's own immune cells, for people with active inflammatory muscle diseases like dermatomyositis. The therapy aims to reset the immune system by targeting and removing certain immune cells. Researchers will check if it is safe and if it can improve muscle strength and reduce the need for other medications. About 74 adults and children with active disease despite standard treatments will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CABA-201 (a CAR-T cell therapy made from the patient's own immune cells, designed to target and destroy certain immune cells)
- What this could lead to
- If successful, this could offer a new treatment option that reduces muscle inflammation and allows patients to lower or stop their current medications.
- What could go wrong
- This is an early-phase trial with a small number of participants. CAR-T therapies can cause serious side effects like cytokine release syndrome. It may not work for everyone or may have limited long-term benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago - Accepting Young Adult and Juvenile Patients
RECRUITINGChicago, Illinois, 60611, United States
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Boston Children's Hospital - Accepting Young Adults and Juvenile Patients
RECRUITINGBoston, Massachusetts, 02115, United States
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Children's Healthcare of Atlanta - Accepting Juvenile Patients
RECRUITINGAtlanta, Georgia, 30029, United States
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Children's Hospital Colorado - Accepting Juvenile Patients
RECRUITINGAurora, Colorado, 80046, United States
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Children's Hospital at Montefiore - Accepting Young Adult and Juvenile Patients
RECRUITINGThe Bronx, New York, 10467, United States
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Children's Hospital of Philadelphia - Accepting Young Adult and Juvenile Patients
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Wisconsin Pediatric Rheumatology -Accepting Young Adult and Juvenile Patients
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Duke University Medical Center - Accepting Young Adults and Juvenile Patients
RECRUITINGDurham, North Carolina, 27710, United States
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Emory University - Accepting Adult Patients
RECRUITINGAtlanta, Georgia, 30032, United States
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Hospital for Special Surgery - Accepting Adult and Juvenile Patients
RECRUITINGNew York, New York, 10021, United States
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Houston Methodist Hospital - Accepting Adult Patients
RECRUITINGHouston, Texas, 77030, United States
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Johns Hopkins All Children's Hospital - Accepting Juvenile Patients
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Kings College Hospital NHS Foundation Trust - Accepting Adult Patients
RECRUITINGLondon, SE5 9RS, United Kingdom
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Manchester Royal Infirmary - Accepting Adult Patients
RECRUITINGManchester, M13 9WL, United Kingdom
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Mayo Clinic - Accepting Adult Patients
RECRUITINGRochester, Minnesota, 55902, United States
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Mayo Clinic Florida - Accepting Adult Patients
RECRUITINGJacksonville, Florida, 32224, United States
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Memorial Sloan Kettering Cancer Center - Accepting Adult and Juvenile Patients
RECRUITINGNew York, New York, 10021, United States
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National Institutes of Health - Accepting Adult and Juvenile Patients
RECRUITINGBethesda, Maryland, 20892, United States
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Northwestern Memorial Hospital - Accepting Adult Patients
RECRUITINGChicago, Illinois, 60611, United States
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Oregon Health & Science University - Accepting Adult Patients
RECRUITINGPortland, Oregon, 97239, United States
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Primary Children's Hospital/University of Utah - Accepting Juvenile Patients
RECRUITINGSalt Lake City, Utah, 84113, United States
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Salford Royal Hospital - Accepting Adult Patients
RECRUITINGSalford, M6 8HD, United Kingdom
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Seattle Children's Research Institute - Accepting Juvenile Patients
RECRUITINGSeattle, Washington, 98105, United States
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The University of Chicago Medical Center - Accepting Adult and Juvenile Patients
RECRUITINGChicago, Illinois, 60637, United States
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UPMC Arthritis and Autoimmunity Center - Accepting Adult Patients
RECRUITINGPittsburgh, Pennsylvania, 15261, United States
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UPMC Children's Hospital of Pittsburgh - Accepting Juvenile Patients
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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University College London Hospitals NHS Foundation Trust - Accepting Adult Patients
RECRUITINGLondon, WC1N 3BG, United Kingdom
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University of California Irvine - Accepting Adult Patients
RECRUITINGOrange, California, 92868, United States
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University of California, San Francisco Benioff Children's Hospital - Accepting Young Adult and Juvenile Patients
RECRUITINGSan Francisco, California, 94158, United States
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University of Kansas Medical Center - Accepting Adult Patients
RECRUITINGKansas City, Kansas, 66160, United States
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University of Michigan - Accepting Young Adult and Juvenile Patients
RECRUITINGAnn Arbor, Michigan, 48105, United States
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University of North Carolina at Chapel Hill - Accepting Adult Patients
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Texas MD Anderson Cancer Center - Accepting Adult Patients
RECRUITINGHouston, Texas, 77030, United States
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University of Texas Southwestern Medical Center - Accepting Juvenile Patients
RECRUITINGDallas, Texas, 75390, United States
Contact Email: •••••@•••••
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Vanderbilt University Medical Center - Accepting Adult Patients
RECRUITINGNashville, Tennessee, 37232, United States
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