Could a simple injection melt away painful calcium deposits?
NCT ID NCT06672822
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether injecting sodium thiosulfate directly into painful calcium deposits (calcinosis) can shrink them and ease symptoms. Twenty adults with scleroderma, dermatomyositis, or mixed connective tissue disease will receive ultrasound-guided injections. The main goal is to see if the lumps get smaller after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sodium thiosulfate
- What this could lead to
- If it works, this could offer a new way to reduce painful calcium lumps under the skin without major surgery.
- What could go wrong
- This is a very small early-stage trial with only 20 people, so results may not apply to everyone. The injections are directly into the lesion and could cause pain or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UPMC Arthritis and Autoimmunity Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Other studies related to the condition(s) this trial covers.
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