SYSTEMIC SCLEROSIS

This study tests whether a new treatment called BMS-986353 (a type of CAR T cell therapy) works better than current standard treatments for people with active systemic sclerosis, a disease that causes scarring in the skin and lungs. About 92 adults with lung involvement will be r…

This study tests an oral drug called nerandomilast in 448 adults with systemic sclerosis (scleroderma), a disease that causes skin thickening and organ damage. Participants are randomly assigned to take the drug or a placebo twice daily for up to 4 years. The goal is to see if th…

This early study tests a new treatment called CD19 UCAR-T cell therapy for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses a patient's own immune cells, modified to target and calm the overactive immune system. The main goals are t…

This study will observe sleep-disordered breathing in 30 adults with systemic sclerosis (scleroderma), a condition that causes skin and organ hardening. Participants will undergo an overnight sleep test to measure breathing pauses. The goal is to better understand how common and …

This study will collect medical information and biological samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. The goal is to create a database and biobank to help researchers identify biological markers and un…

This study looks at whether a substance in the blood called catestatin can help doctors understand how active systemic sclerosis (a rare autoimmune disease) is, especially when it affects the heart and small blood vessels. Researchers will compare catestatin levels in 70 people w…

This study aims to find the most effective way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how …