SYSTEMIC SCLEROSIS

This study is testing whether an investigational drug called MT-0551 is better than a placebo at reducing skin thickening in people with systemic sclerosis (scleroderma). The 80 participants will receive either the drug or a placebo for 26 weeks, and researchers will measure chan…

This study is testing whether a medication called anifrolumab, given as a weekly injection, can safely help control the symptoms and slow the progression of systemic sclerosis (scleroderma). It will involve about 314 adults with a recent diagnosis of the disease. Participants wil…

This is an early-stage study testing a new personalized cell therapy called KITE-363 for people with severe autoimmune diseases that haven't improved with standard treatments. The therapy involves modifying a patient's own immune cells to target and remove harmful B cells, which …

This study is testing a new type of cell therapy for people with severe lupus or scleroderma that hasn't responded to standard treatments. Doctors are giving patients a single infusion of specially engineered immune cells designed to target and reduce harmful B cells. The main go…

This early-stage study is testing a new personalized cell therapy called KYV-101 for adults with active, diffuse systemic sclerosis (scleroderma). The therapy involves modifying a patient's own immune cells to target and remove certain B-cells thought to drive the disease. The ma…

This study is testing whether a drug called baricitinib can safely reduce skin thickening and control disease activity in people with early, severe systemic sclerosis, a rare autoimmune disease that hardens skin and can damage internal organs. It will compare baricitinib against …

This early-stage study is testing the safety of a new two-part cell therapy (SYNCAR-001 + STK-009) in adults with severe forms of lupus or scleroderma that haven't responded to other treatments. The therapy involves collecting and modifying a patient's own immune cells (CAR-T cel…

This early-stage study is testing the safety and initial effects of a therapy called RD06-04, a type of CAR-T cell injection, in adults with active autoimmune diseases like lupus, scleroderma, and vasculitis. The therapy involves collecting a patient's own immune cells, modifying…

This study is testing different ways to help people with inflammatory arthritis who face life challenges like unstable housing or transportation issues that make it hard to get medical care. It compares three levels of support: a simple resource list, help from a community specia…

This study is checking if the Shingrix shingles vaccine is safe and works well for people with autoimmune rheumatic diseases like lupus or rheumatoid arthritis. These patients are at high risk for shingles but are often on medications that weaken the immune system. Researchers ar…

This small pilot study is testing whether a fecal microbiota transplant (FMT), which transfers healthy gut bacteria from a donor, is safe and can help reduce chronic diarrhea in people with systemic sclerosis (scleroderma). Twenty participants will be randomly assigned to receive…

This study aims to see if a computer program (AI) can analyze old chest CT scans to predict which patients with scleroderma-related lung scarring will get worse. It will look at about 1,000 patients' past scans and health records to find patterns. The goal is to help doctors iden…