Experimental CAR-T therapy takes aim at Hard-to-Treat scleroderma
NCT ID NCT06400303
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial is testing a new treatment called KYV-101 for people with systemic sclerosis, a disease where the immune system attacks the body, causing skin and organ damage. The therapy uses a patient's own modified immune cells to target and destroy certain B cells that may drive the disease. Only 3 participants are enrolled, and the main goals are to check safety and see if the treatment can improve symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- KYV-101 (a type of CAR-T cell therapy made from the patient's own immune cells, designed to target and destroy B cells)
- What this could lead to
- If successful, this could point toward a new treatment option for systemic sclerosis that targets the immune system's role in the disease.
- What could go wrong
- This is a very early, small trial with only 3 participants, so results may not apply to everyone. CAR-T therapy can cause serious side effects like cytokine release syndrome and infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Northwell Health
Great Neck, New York, 11021, United States
-
Stanford University Medical Center
Palo Alto, California, 94305, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Blood particles may reveal hidden clues to scleroderma complications
- Could a simple injection dissolve painful calcium lumps in rare diseases?
- Finger injections aim to loosen stiff hands in scleroderma
- Continued anifrolumab treatment studied for lupus and related diseases
- Blood thinner may stop autoimmune disease before it starts