SYSTEMIC SCLEROSIS

This study tests whether a stem cell transplant using the patient's own cells can help young people (ages 8 to 25) with life-threatening lupus or scleroderma. The goal is to wipe out the faulty immune system and allow a new, healthy one to grow. The trial will track how long pati…

This study tests a new treatment for people with autoimmune disorders like systemic sclerosis, lupus, and lupus nephritis. It combines a special immune cell therapy (AD-PluReceptor-NK cells) with a drug called tafasitamab and chemotherapy to try to control the disease. The study …

This early-stage study is testing a new treatment using a patient's own immune cells, modified to target and attack faulty immune cells that cause autoimmune diseases like lupus, scleroderma, and Sjogren's syndrome. The goal is to see if this approach is safe and can control dise…

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goal is to check safety and find the right dose,…

This early-phase study tests a new treatment called RD06-05, which uses a patient's own immune cells modified to target and reset the immune system in autoimmune diseases like lupus, multiple sclerosis, and vasculitis. The goal is to check safety and how well the body tolerates i…

This early-stage trial tests a new treatment called AZD0120 for adults with three autoimmune diseases: systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. AZD0120 is made from a patient's own immune cells, which are modified in a la…

This early-phase study tests a new type of CAR-T cell therapy (called KN3601) for people with severe autoimmune diseases like lupus, scleroderma, Sjögren's syndrome, rheumatoid arthritis, and vasculitis that haven't responded to standard treatments. The therapy uses specially eng…

This early-stage study tests a new cell therapy called YTS109 in 18 adults with severe autoimmune diseases like lupus and Sjogren's syndrome that have not responded to standard treatments. Participants receive a single infusion of these specially designed cells. The main goal is …

This study tests whether injecting stem cells from fat tissue into the fingers can heal painful, non-healing ulcers caused by scleroderma. About 32 adults with at least one such ulcer will receive either stem cells or a placebo. The main goal is to see if the ulcers heal complete…

This early-stage study tests a one-time treatment made from donor immune cells that are edited with CRISPR to target and calm the overactive immune system. It is for 80 adults with lupus, scleroderma, or myositis that have not responded to standard therapies. The main goal is to …

This study tests whether injecting donor stem cells into the hand can safely help heal painful finger ulcers in people with scleroderma that have not improved with standard treatments. Twenty adults with at least one active, hard-to-heal ulcer will receive the injections and be m…

This study tests whether combining two drugs (nintedanib and tocilizumab) works better than standard treatments for lung scarring caused by scleroderma. About 86 adults will take the combo or standard therapy for 56 weeks. The main goal is to see if the combo helps preserve lung …

This early-phase study is testing a new treatment using a patient's own immune cells, modified to target and calm the overactive immune system in people with severe lupus, scleroderma, or Sjogren's syndrome with lung complications. The main goal is to check if the treatment is sa…

This study tests whether adding two immune-targeting drugs (belimumab and rituximab) to standard therapy can improve skin hardening and other symptoms in people with early, severe scleroderma. About 30 adults will receive either the drug combination or placebo, plus their usual m…

This study tests a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like rheumatoid arthritis, lupus, and scleroderma. The therapy aims to reset the immune system by targeting and removing faulty B cells. About 72 adults will re…

This study tests a new treatment using a patient's own immune cells, modified to target and destroy harmful cells causing three severe autoimmune diseases: lupus nephritis, systemic sclerosis, and Sjogren's syndrome with lung hypertension. About 45 adults will receive a single in…

This early-stage study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy faulty B cells that dr…

This study tests a new treatment called QT-219CX, which uses specially engineered immune cells (CAR-T cells) to target and calm the overactive immune system in people with autoimmune diseases like lupus, kidney disease, and scleroderma. The treatment is given as a one-time infusi…

This early-phase study tests a new treatment called CC-97540, which uses a person's own immune cells (CAR T cells) to target and calm overactive immune responses in severe autoimmune diseases like lupus, myositis, scleroderma, and rheumatoid arthritis. The goal is to see if it is…

This study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can improve lung function and skin hardening better than current treatments for people with active systemic sclerosis, a rare autoimmune disease. About 92 adults with lung involvement …

This study tests a new treatment for people with lupus, scleroderma, dermatomyositis, or polymyositis. The treatment uses a patient's own immune cells, which are modified in a lab to find and attack faulty B cells that drive the disease. The goal is to control the autoimmune atta…

This study tests a new treatment called NKX019 for people with autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis. NKX019 uses specially engineered immune cells to target and calm the overactive immune system. The goal is to see if it is safe and can control di…

This study tests a stem cell transplant for people aged 8-24 with severe systemic sclerosis (scleroderma) that hasn't improved with standard treatments. The approach uses high-dose therapy to reset the immune system, followed by a transplant of the patient's own blood stem cells.…

This study tests a drug called nemolizumab in adults with systemic sclerosis, a disease that causes skin to harden and tighten. The main goal is to see if the drug can reduce skin thickness and find the best dose. About 162 participants will receive either nemolizumab or a placeb…

This study tests whether itacitinib is safe and effective for adults with systemic sclerosis, a disease that causes skin thickening and organ damage. About 74 participants with early or active disease will receive the drug or a placebo for one year. The main goal is to see if it …

This early-stage study tests a new drug called XmAb657 in 60 people, including healthy volunteers and those with autoimmune diseases like scleroderma or Sjögren's. The main goal is to see if the drug is safe and tolerable when given as a shot under the skin. Researchers will also…

This study tests whether a personalized facial rehabilitation program can improve mouth function and quality of life in people with systemic sclerosis (scleroderma) who have facial tightness and difficulty opening their mouth. About 60 adults will be assigned to either the rehab …

This study aims to better understand systemic sclerosis, a rare disease that causes hardening of the skin and organs. Researchers will analyze skin and blood samples from 40 adults with the condition to see how different cell types interact. The goal is to find new clues that cou…

This study is creating a large database and biobank from 2200 patients with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track patients over time to identify new markers that can predict disease activity, treatment response, an…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study follows 500 adults with systemic sclerosis (a rare autoimmune disease causing skin and organ hardening) for up to 5 years. Researchers will track how the disease naturally progresses, including complications like lung or kidney problems, and collect blood samples to be…

This study is building a large registry and biorepository of 5000 adults with various rheumatic diseases like rheumatoid arthritis and lupus. Researchers will collect medical information and biological samples over time to identify patterns and biomarkers. The goal is to better u…

This study looks at the gut bacteria of 60 people with systemic sclerosis (a chronic autoimmune disease) and compares them to healthy volunteers. Researchers want to see how the bacteria change over 7 months and if these changes can help diagnose or treat the disease better. Part…