SYSTEMIC SCLEROSIS
Clinical trials for SYSTEMIC SCLEROSIS explained in plain language.
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New pill could slow down debilitating scleroderma
Disease control Not yet recruitingThis study tests a new oral drug, nerandomilast, in adults with systemic sclerosis (scleroderma), a condition that causes skin thickening and organ damage. About 448 participants will be randomly assigned to receive either the drug or a placebo twice daily for up to 4 years. The …
Matched conditions: SYSTEMIC SCLEROSIS
Phase: PHASE3 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 12, 2026 12:09 UTC
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Engineered immune cells take on lupus and other autoimmune diseases
Disease control Not yet recruitingThis early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…
Matched conditions: SYSTEMIC SCLEROSIS
Phase: NA • Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Disease control
Last updated Jun 12, 2026 12:08 UTC
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Off-the-Shelf CAR-Ts take on lupus and more
Disease control Not yet recruitingThis early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…
Matched conditions: SYSTEMIC SCLEROSIS
Phase: EARLY_PHASE1 • Sponsor: Nanjing Bioheng Biotech Co., Ltd. • Aim: Disease control
Last updated Jun 12, 2026 12:04 UTC
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500-Person biobank aims to unlock secrets of autoimmune diseases
Knowledge-focused Not yet recruitingThis study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …
Matched conditions: SYSTEMIC SCLEROSIS
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:08 UTC
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Blood protein may reveal hidden heart risks in scleroderma
Knowledge-focused Not yet recruitingThis study looks at whether a substance called catestatin in the blood can be used as a marker for disease activity in people with systemic sclerosis (scleroderma). Researchers will compare catestatin levels in 70 patients with the disease to healthy volunteers. The goal is to se…
Matched conditions: SYSTEMIC SCLEROSIS
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:04 UTC
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Scleroderma patients to decide: infographic vs. plain language for research results
Knowledge-focused Not yet recruitingThis study aims to find the best way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how complete, …
Matched conditions: SYSTEMIC SCLEROSIS
Phase: NA • Sponsor: Lady Davis Institute • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:02 UTC
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Ultrasound peers into gut vessels of scleroderma patients
Knowledge-focused Not yet recruitingThis study uses ultrasound to look at blood flow in the gut of people with systemic sclerosis (scleroderma) compared to healthy volunteers. Researchers want to see how gut blood vessel changes relate to digestive symptoms and other organ problems. The goal is to better understand…
Matched conditions: SYSTEMIC SCLEROSIS
Sponsor: Esraa Moustafa Mohammed • Aim: Knowledge-focused
Last updated Jun 09, 2026 12:10 UTC
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Hidden sleep problems in scleroderma patients to be uncovered
Knowledge-focused Not yet recruitingThis study looks at sleep breathing problems in people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and organs. Researchers will use an overnight sleep test to measure pauses in breathing during sleep. The goal is to find out how common these…
Matched conditions: SYSTEMIC SCLEROSIS
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 09, 2026 12:08 UTC