SYSTEMIC SCLEROSIS

This study tested whether giving a stem cell transplant early is better than standard immunosuppressive drugs for people with early, severe scleroderma (a rare autoimmune disease that causes skin hardening and organ damage). Sixty adults aged 18-65 were randomly assigned to eithe…

This early study tested a drug called nemolizumab in 6 adults with systemic sclerosis, a rare disease that causes skin to harden and tighten. The main goal was to see if the drug could reduce skin thickness over 24 weeks. Researchers also checked for side effects and how the drug…

This study looked at whether bosentan, a drug that helps blood vessels relax, can improve blood flow in the hands of people with systemic sclerosis (scleroderma) who have had finger ulcers. 18 adults with reduced hand blood flow and a history of ulcers took part. The main goal wa…

This study tested whether adding intravenous cyclophosphamide to prednisone can stabilize or improve lung function in people with scleroderma whose lung disease is getting worse. The trial enrolled 40 adults with significant lung volume or gas exchange decline in the past year. T…

This study tested whether a painless, radiation-free chest ultrasound can spot early signs of lung disease in people with systemic scleroderma, a condition that often leads to deadly lung scarring. Researchers studied 30 adults who had no detectable lung damage on standard CT sca…

This trial tested an online self-management program for people with scleroderma, a chronic autoimmune disease. The program includes educational videos and group video calls led by trained peers. The goal was to see if it helps patients feel more confident managing their condition…

This study tested whether a personalized home exercise program is practical for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants did one supervised session and then followed a 3-month home exercise plan. The goal was to see if patient…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with scleroderma (systemic sclerosis) who have arthritis. 22 participants with active arthritis took the drug. The main goal was to see if it…

This study tested whether a special MRI technique can measure lung scarring (fibrosis) in people with scleroderma. 24 adults with scleroderma had MRI scans of their lungs while breathing in and out. The goal was to see if MRI could provide a safe, radiation-free way to track lung…

This study tested whether special MRI scans can detect and track lung disease in people with scleroderma. Researchers compared MRI results with CT scans in 25 adults. The goal was to see if MRI could be a safe, radiation-free way to monitor lung health in this condition.

This study looked at the experiences of 50 family caregivers of people with systemic sclerosis (scleroderma), a rare and serious disease. Researchers wanted to understand how caregiving affects caregivers' physical, mental, and social health. The goal is to use this information t…

This study looked at whether eosinophils, a type of white blood cell, help cause fibrosis (scarring) in systemic sclerosis, an autoimmune disease that hardens skin and lungs. Researchers compared blood and tissue samples from 40 patients with systemic sclerosis and 30 healthy vol…

This study followed 150 adults with systemic sclerosis (scleroderma) for two years to understand how often malnutrition occurs and what factors contribute to it. Researchers checked weight, diet, and quality of life every six months. If malnutrition was found, patients received d…

This study looked at 30 adults with systemic sclerosis (scleroderma) to see how the disease affects blood vessels in the arms and belly. Researchers used a special ultrasound to check the radial, ulnar, and splanchnic vessels. The goal was to better understand blood vessel proble…

This study looked at whether certain immune system markers (autoantibodies) are linked to how pulmonary arterial hypertension (PAH) progresses. Researchers tested blood samples from 629 adults with different types of PAH, including those with HIV, congenital heart defects, and co…

This study compared two different machines that measure how well the lungs transfer nitric oxide and carbon monoxide. Nine adults with systemic sclerosis and related lung disease took both tests in random order. The goal was to see if the devices give the same results in people w…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study tested a smartphone app called RENEW designed to help people with scleroderma build resilience and manage fatigue. Researchers wanted to see if people would use the app and find it helpful. 43 adults with scleroderma and moderate to severe fatigue took part. The main g…

This study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening. Researchers collected skin samples from 350 adults aged 18 to 75 to measure a specific protein (OX40L) on blood…

This study followed 56 adults with systemic sclerosis (scleroderma) who also had a serious lung complication called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict faster decli…

This study looked at how changes in the skin caused by systemic sclerosis (scleroderma) affect a person's feelings about their appearance. Researchers compared 170 patients with the disease to healthy volunteers using questionnaires about body image and distress. The goal was to …

This study looked at 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form in the hands and feet. Instead of just checking the skin, researchers used X-rays to get a clearer picture. They also checked whether these deposits were linked to da…

This study aimed to create a standard set of questions to measure how systemic sclerosis (scleroderma) affects patients' lives. Researchers worked with 100 patients and experts to identify the most important areas to track. The goal was to develop a tool that can be used in clini…