Engineered immune cells target three autoimmune diseases in first human trial
NCT ID NCT07085104
First seen Feb 04, 2026 · Last updated May 01, 2026 · Updated 10 times
Summary
This early-stage study tests a new treatment called ALLO-329, made from donor immune cells engineered to attack two targets (CD19 and CD70) involved in autoimmune diseases. It is for adults with lupus (with or without kidney inflammation), myositis, or scleroderma. The main goals are to check safety and find the right dose, while also looking for signs that the treatment can control disease activity.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Astera Cancer Care
RECRUITINGEast Brunswick, New Jersey, 08816, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Hôpital Maisonneuve Rosemont
RECRUITINGMontreal, Quebec, H1T 2M4, Canada
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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LDS Hospital - lntermountain Health
RECRUITINGSalt Lake City, Utah, 84143, United States
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Mayo Clinic
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic
RECRUITINGJacksonville, Florida, 32224, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29605, United States
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Norton Cancer Institute, St. Matthews Campus
RECRUITINGLouisville, Kentucky, 40207, United States
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Prisma Health
RECRUITINGGreenville, South Carolina, 29425, United States
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The University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Colorado Denver
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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Conditions
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