New hope for rare disease: drug may ease skin hardening in systemic sclerosis

NCT ID NCT05300932

First seen Jan 28, 2026 · Last updated May 12, 2026 · Updated 11 times

Summary

This study tests whether baricitinib, a drug that calms the immune system, can help people with systemic sclerosis—a rare disease that causes skin to harden and can affect organs like the lungs and heart. About 60 adults with early-stage disease will receive either baricitinib or a placebo for 24 weeks. The main goal is to see if the drug reduces skin thickness, measured by a standard scoring method.

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Contacts and locations

Locations

  • Department of RheumatologyTongji Hospital

    Wuhan, Hubei, 430030, China

  • Tongji Hospital

    Wuhan, Hubei, 430030, China

Conditions

Explore the condition pages connected to this study.