Engineered immune cells take aim at Hard-to-Treat autoimmune diseases

NCT ID NCT07038447

First seen Jan 06, 2026 · Last updated Jun 09, 2026 · Updated 26 times

Summary

This early-phase study tests KITE-363, a personalized therapy where a patient's own immune cells are modified to target and attack faulty B cells that drive autoimmune diseases like lupus and scleroderma. About 52 adults with severe, treatment-resistant forms of these conditions will receive the therapy to see if it is safe and can reduce disease activity. The goal is to find the right dose and measure improvements in symptoms over six months.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Concord Repatriation General Hospital

    Sydney, New South Wales, 2139, Australia

  • Jewish General Hospital

    Montreal, H3T1E2, Canada

  • St Vincent's Hospital

    Fitzroy, Victoria, 3065, Australia

  • Stanford University

    Stanford, California, 94305, United States

  • The Ottawa Hospital, General Campus

    Ottawa, K1H 8L6, Canada

Conditions

Explore the condition pages connected to this study.