New hope for scleroderma: experimental drug anifrolumab in Late-Stage trial

NCT ID NCT05925803

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 28 times

Summary

This study tests whether anifrolumab, given as a shot under the skin, can help adults with systemic sclerosis (a disease causing skin thickening and organ damage). About 314 people aged 18 to 70 with early-stage disease will receive either the drug or a placebo. The goal is to see if the drug improves skin, lung function, and daily life without causing serious side effects.

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Contacts and locations

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Locations

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Scottsdale, Arizona, 85259, United States
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Chula Vista, California, 91910, United States
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Los Angeles, California, 90095, United States
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Orange, California, 92868, United States
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Aurora, Colorado, 80045, United States
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New Haven, Connecticut, 06519, United States
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Washington D.C., District of Columbia, 20007, United States
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Boca Raton, Florida, 33486, United States
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Fort Lauderdale, Florida, 33309, United States
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Gainesville, Florida, 32603, United States
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Jacksonville, Florida, 32216, United States
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Margate, Florida, 33063, United States
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South Miami, Florida, 33143, United States
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Tamarac, Florida, 33321, United States
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Chicago, Illinois, 60611, United States
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Kansas City, Kansas, 66160, United States
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New Orleans, Louisiana, 70121, United States
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Baltimore, Maryland, 21224, United States
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Ann Arbor, Michigan, 48109, United States
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Rochester, Minnesota, 55905, United States
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Babylon, New York, 11702, United States
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New York, New York, 10032, United States
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Cincinnati, Ohio, 45219, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Allen, Texas, 75013, United States
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Houston, Texas, 77030, United States
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Vienna, 1090, Austria
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Ghent, B-9000, Belgium
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Leuven, 3000, Belgium
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Calgary, Alberta, T2N 4Z6, Canada
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Toronto, Ontario, M5T 3L9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Québec, G1V 3M7, Canada
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Beijing, 100191, China
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Beijing, CN-100730, China
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Guangzhou, 510100, China
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Guangzhou, 510530, China
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Hangzhou, 310014, China
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Lanzhou, 730000, China
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Shanghai, 200032, China
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Shanghai, 201210, China
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Tianjin, 300050, China
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Bordeaux, 33076, France
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Brest, 29609, France
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Paris, 75020, France
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Paris, 75679, France
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Rennes, 35033, France
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Strasbourg, 67098, France
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Toulouse, 31059, France
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Freiburg im Breisgau, 79106, Germany
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Mainz, 55131, Germany
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Minden, 32429, Germany
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Münster, 48149, Germany
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Tübingen, 72076, Germany
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Budapest, 1023, Hungary
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Budapest, 1027, Hungary
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Budapest, 1138, Hungary
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Debrecen, 4032, Hungary
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Pécs, 7632, Hungary
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Szeged, 6725, Hungary
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Ahmedabad, 380006, India
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Delhi, 110060, India
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Gurugram, 122001, India
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Hyderabad, 500082, India
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Kolkata, 700020, India
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Mumbai, 400053, India
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Mysuru, 570004, India
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New Delhi, 11029, India
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Pune, 411001, India
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Secunderabad, 500003, India
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Afula, 18101, Israel
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Haifa, 31048, Israel
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Haifa, 31096, Israel
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Jerusalem, 00000, Israel
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Kfar Saba, 4428164, Israel
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Ramat Gan, 52621, Israel
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Ancona, 60126, Italy
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Brescia, 25123, Italy
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Cona, 44124, Italy
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Milan, 20122, Italy
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Padova, 35128, Italy
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Roma, 00128, Italy
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Roma, 00168, Italy
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Roma, 161, Italy
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Bunkyō City, 113-8603, Japan
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Fukuoka, 812-8582, Japan
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Iruma-Gun, 350-0495, Japan
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Kanazawa, 920-8641, Japan
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Maebashi, 371-8511, Japan
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Nagasaki, 852-8501, Japan
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Nagoya, 457-0866, Japan
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Sapporo, 060-8638, Japan
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Sendai, 980-8574, Japan
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Shinjuku-ku, 160-8582, Japan
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Shinjuku-ku, 162-8666, Japan
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Suita-shi, 565-0871, Japan
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Takatsuki-shi, 569-8686, Japan
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Toyoake-shi, 470-1192, Japan
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Yokohama, 236-0004, Japan
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Kuala Lumpur, 59100, Malaysia
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Kuching, 93586, Malaysia
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Seremban, 70300, Malaysia
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Chihuahua City, 31000, Mexico
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Guadalajara, 44158, Mexico
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Guadalajara, 44650, Mexico
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Mexico City, 06700, Mexico
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San Luis Potosí City, 78213, Mexico
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San Luis Potosí City, 78250, Mexico
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Groningen, 9713 GZ, Netherlands
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Bydgoszcz, 85-168, Poland
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Krakow, 30-002, Poland
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Krakow, 30-721, Poland
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Lodz, 90-549, Poland
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Sosnowiec, 41-200, Poland
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Warsaw, 00-874, Poland
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Bucharest, 011172, Romania
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Bucharest, 020475, Romania
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Cluj-Napoca, 400006, Romania
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Iași, 700661, Romania
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Parktown, 2193, South Africa
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Pretoria, South Africa
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Busan, 49241, South Korea
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Seoul, 03080, South Korea
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Seoul, 04401, South Korea
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Seoul, 04763, South Korea
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Seoul, 137-701, South Korea
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A Coruña, 15006, Spain
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Barcelona, 08003, Spain
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Barcelona, 08041, Spain
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Madrid, 28041, Spain
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Málaga, 29009, Spain
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Valencia, 46017, Spain
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Valencia, 46026, Spain
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Antalya, 07059, Turkey (Türkiye)
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Center, 23200, Turkey (Türkiye)
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Kazımkarabekir, 01230, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Cannock, WS11 2XY, United Kingdom
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Leeds, LS7 4SA, United Kingdom
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London, NW3 2QG, United Kingdom
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Sheffield, S10 2JF, United Kingdom
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Hanoi, 10000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Hochiminh, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

SCLERODERMA SYSTEMIC SCLEROSIS SYSTEMIC SCLEROSIS