SCLERODERMA

This study tested whether using a stem cell transplant early is better than standard immunosuppressive drugs for people with early, severe scleroderma. Sixty adults with diffuse scleroderma were randomly assigned to get either an upfront stem cell transplant or usual care with cy…

This early-phase study tested a drug called brentuximab vedotin, originally used for lymphoma, in 17 people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The main goal was to see if the drug is safe and tolerable. Researchers monitored for serious side…

This study tested whether adding a strong immune-suppressing drug (cyclophosphamide) to standard steroid treatment (prednisone) could stop or slow lung damage in people with scleroderma-related lung disease. 40 adults with worsening lung function took part. The goal was to see if…

This small early study tested a new way to treat microstomia (mouth tightening) caused by scleroderma. Three adults received three sessions of a laser followed by hyaluronidase enzyme application to loosen the skin around the mouth. The goal was to increase mouth opening for easi…

This study tested whether gentle yoga and breathing exercises are practical and helpful for people with scleroderma. Thirty participants learned the exercises and practiced twice daily at home for 12 weeks. Researchers measured quality of life, stress, depression, and saliva mark…

This study tested a self-management program for people with scleroderma, a chronic disease that can cause pain, fatigue, and skin problems. The program includes educational videos and group video calls led by trained peers. Researchers wanted to see if it helps patients feel more…

This study looked at 43 adults with scleroderma or unexplained pulmonary hypertension to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over six months. The goal was to learn…

This study looked at whether the way depression questions are arranged affects how people with scleroderma report physical symptoms like sleep problems, fatigue, and appetite changes. Over 800 participants were randomly assigned to answer the same depression questionnaire either …

This study measured prolactin levels in 71 people with systemic sclerosis (scleroderma) to see if high levels are common. Researchers compared results with healthy volunteers matched by age and sex. The goal was to understand if prolactin plays a role in the disease, not to test …

This study tested whether MRI can detect lung disease in people with scleroderma, a condition that can cause scarring in the lungs. Researchers compared MRI results to standard CT scans in 25 adults. The goal was to see if MRI could be a safe, radiation-free way to screen and mon…

This study tested whether a special MRI scan can measure lung scarring (fibrosis) in people with scleroderma. 24 adults with scleroderma had MRI scans while holding their breath at full inhale and full exhale. A computer program then analyzed how the lungs moved, looking for stif…