SCLERODERMA

This completed Phase 3 trial tested whether adding intravenous cyclophosphamide to standard prednisone treatment could better stabilize or improve lung function in people with scleroderma-related lung scarring. The study involved 40 adults whose lung function had recently worsene…

This study aimed to find the best initial treatment for people recently diagnosed with a severe, fast-moving form of scleroderma. It compared two approaches: an aggressive stem cell transplant right away versus starting with standard immunosuppressive drugs and saving the transpl…

This study tested whether a special type of MRI scan could be used to measure lung scarring (fibrosis) in people with scleroderma. Researchers wanted to see if this method, which doesn't use radiation, could be a better and more reproducible way to track the disease compared to c…

This small, completed pilot study explored whether gentle yoga and breathing exercises could help people with scleroderma manage their symptoms and improve their quality of life. Thirty participants learned the exercises and practiced them at home twice daily for 12 weeks while r…

This study tested an online group program designed to help people with scleroderma (systemic sclerosis) better manage their disease and daily symptoms. The program included educational videos and live group video sessions led by trained peers, focusing on challenges like pain, fa…

This research study aims to understand why people with scleroderma and pulmonary hypertension develop heart muscle weakness. Researchers will compare heart function and collect tissue samples from 43 participants during their standard medical procedures. The goal is to identify d…

This study aimed to understand if standard depression questionnaires work accurately for people with scleroderma, a chronic autoimmune disease. Researchers tested whether asking about physical symptoms like fatigue and sleep problems separately from psychological questions change…

This study aimed to understand how common high levels of a hormone called prolactin are in people with systemic scleroderma, a disease that causes hardening and scarring of skin and internal organs. Researchers compared 71 scleroderma patients to healthy volunteers to see if high…