SCLERODERMA

This is an early-stage study testing a new cell therapy called EVM18001 for people with severe, hard-to-treat autoimmune diseases: lupus, scleroderma, and myasthenia gravis. The main goal is to check if the treatment is safe and to find the right dose. Researchers will also look …

This study is testing whether adding a new type of immune cell therapy (called AlloNK) to an existing drug (rituximab) can better control several autoimmune diseases that have come back after standard treatments. The trial will enroll 90 adults with rheumatoid arthritis, Sjögren'…

This study is testing whether sildenafil (the active ingredient in Viagra) can help people with scleroderma who have mildly elevated blood pressure in their lungs. Researchers want to see if the drug improves how far patients can walk in 6 minutes and helps their heart function b…

This study aims to test several new investigational drugs to see if they can slow or stop the progression of lung scarring in people with scleroderma. It will enroll 400 adults who have had scleroderma symptoms for 7 years or less and have evidence of lung involvement. Participan…

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This study is testing whether an investigational drug called tibulizumab can help control systemic sclerosis, a rare autoimmune disease that causes skin thickening and can damage internal organs like the lungs. For the first 24 weeks, some participants will receive the drug while…

This early-stage study is testing a new mRNA-based treatment called HN2301 in people with autoimmune diseases including lupus, scleroderma, and rheumatoid arthritis. The main goal is to check if the treatment is safe and well-tolerated in 30 participants who haven't responded wel…

This early-stage study is testing a single dose of an experimental cell therapy called CABA-201 for adults with active systemic sclerosis (scleroderma). The therapy, known as CAR T-cell therapy, is designed to target and remove a type of immune cell (B cells) thought to drive the…

This study is testing a special exercise program called BETY, designed for people with scleroderma. The program aims to improve physical function, strength, and overall well-being by combining physical activity with psychological and social support. Researchers will enroll 48 chi…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases like rheumatoid arthritis and lupus. The goal is to help researchers better understand what causes these conditions and how they progress over time. …

This study aims to understand how scleroderma, a disease that hardens skin and tissues, affects a person's ability to chew and swallow food. Researchers will enroll 50 children and adults with scleroderma to measure their chewing and swallowing performance using simple tests and …

This study aims to understand the causes of scleroderma by comparing skin cells from patients with the disease to cells from healthy volunteers. Researchers will analyze the genes in these cells to see how they differ. The goal is to learn more about what drives the disease, whic…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study is creating a registry to learn more about how autoimmune diseases affect pregnancy. It will follow 1,000 pregnant women with conditions like lupus or rheumatoid arthritis to identify risk factors for complications. The goal is to gather information that can help impro…

This study aims to understand the natural progression of systemic sclerosis (scleroderma), a rare and serious autoimmune disease with no cure. Researchers will follow 500 patients for five years, collecting detailed health information and blood samples. The goal is to build a cle…

This study aims to understand the relationship between physical abilities and the overall well-being of people living with scleroderma. Researchers will observe 50 children and adults with the condition, using walking tests, questionnaires, and other assessments. The goal is to g…

This study aims to create a large collection of blood samples and health information from people with autoimmune diseases like lupus and scleroderma. Researchers will use these samples to look for new biological markers that could help diagnose diseases earlier, predict how they …

This study is creating a registry to collect health information and optional blood samples from adults with scleroderma. The goal is to better understand this complex disease, its causes, and how it progresses. This knowledge will help researchers develop future treatments for a …