New pill shows promise for early rheumatoid arthritis in Mid-Stage trial

NCT ID NCT06671054

Recruiting now Disease control Sponsor: SynAct Pharma Aps Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests an oral drug called AP1189 in 240 people with early rheumatoid arthritis who have not yet taken disease-modifying drugs. Participants receive one of three doses of AP1189 or a placebo, all alongside standard methotrexate, for 12 weeks. The goal is to see if AP1189 safely reduces joint inflammation and disease activity better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AP1189 (an oral tablet) taken alongside methotrexate
What this could lead to: If successful, this could point toward a new treatment option for early rheumatoid arthritis that helps control inflammation and disease activity.
What could go wrong: This is an early Phase 2 trial with only 240 participants, so results may not confirm effectiveness. The drug is still experimental, and side effects are not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS (RA)

Contacts and locations

Show contact details

Locations

Altoona Center for Clinical Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States

Contact Email: •••••@•••••
DC-MED Michal Kowalski S.K.
RECRUITING

Swidnica, 58-100, Poland
Diagnostic Consultative Center Aleksandrovska
RECRUITING

Sofia, 1431, Bulgaria
IMSP Spitalul Clinic Municipal "Sfanta Treime"
RECRUITING

Chisinau, 2068, Moldova
M2Mmed
RECRUITING

Chorzów, 41-500, Poland
Medical Center Tera Medico
RECRUITING

Vratsa, 3000, Bulgaria
Medyczne Centrum Hetmańska
RECRUITING

Poznan, 60-218, Poland
Millennium Medical Research LLC
RECRUITING

Miami, Florida, 33126, United States
Nouvelle Clinical Research LLC
RECRUITING

Cutler Bay, Florida, 33189, United States

Contact Email: •••••@•••••
Sanos Clinic Herlev
RECRUITING

Herlev, 2730, Denmark

Contact Email: •••••@•••••
Vita Longa Sp. z o. o.
RECRUITING

Katowice, 41-500, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.