RHEUMATOID ARTHRITIS (RA)

This study is testing whether a single-dose dengue vaccine is safe and works well for people with autoimmune diseases like rheumatoid arthritis or lupus. Researchers will compare about 320 patients with these conditions to 160 healthy volunteers, all living in areas where dengue …

This study is testing whether a new capsule called QLS12010 can safely reduce disease activity in adults with moderate-to-severe rheumatoid arthritis. It will involve 180 participants who haven't gotten enough relief from at least two standard arthritis medications. People will b…

This early-stage study is testing a new drug called S-4321 in adults with autoimmune diseases like rheumatoid arthritis, psoriasis, lupus, or eczema. The main goal is to check the drug's safety, how the body processes it, and look for early signs it might help control these condi…

This early-stage study is testing an experimental treatment called QEL-005 in adults with two severe autoimmune conditions: difficult-to-treat rheumatoid arthritis and a serious form of systemic sclerosis. The treatment involves taking a patient's own immune cells, modifying them…

This study aims to understand how two common types of rheumatoid arthritis (RA) medications affect patients' physical fitness, muscle strength, and feelings of fatigue. Researchers will compare 40 adults with RA who have been taking either anti-TNF-α drugs or other non-TNF-α drug…

This study aims to find the safest way to reduce steroid use in people with rheumatoid arthritis who have been taking low doses long-term. Researchers will compare two different tapering methods over six months in 206 patients to see which better maintains disease control while r…

This study aims to find out if a standard blood test for diabetes (HbA1c) gives false readings in people with inflammatory arthritis who take the drug sulfasalazine. Researchers will compare this standard test with continuous glucose monitors worn by 75 patients to see if diabete…

This study is testing whether a gentle electrical stimulation treatment can help reduce fatigue and improve leg muscle strength in people with rheumatoid arthritis (RA). It will compare the real stimulation against a sham (fake) treatment in 84 participants over 12 weeks. The goa…

This study aims to see if teaching patients about how pain works in the brain (pain neuroscience education) or gently stimulating a major nerve (vagus nerve stimulation) works better than traditional exercise for people with rheumatoid arthritis. Researchers will enroll 36 adults…

This study is testing whether a specific 6-week resistance training program can improve muscle strength in people with rheumatoid arthritis (RA). About 118 adults with RA will be split into two groups: one will follow the new exercise plan, while the other continues their usual c…

This study aims to find out if a single steroid injection works as well as a 3-week course of steroid pills for reducing the pain and stiffness of a rheumatoid arthritis (RA) flare-up. Researchers will compare the two treatments in 220 adults with RA who are having a flare. The m…

This study is testing whether a smartphone app that uses artificial intelligence to create personalized exercise plans can help people with rheumatoid arthritis move their knees better and feel less pain. It will compare the AI app to traditional paper exercise instructions and t…

This study aims to see if adding lavender aromatherapy massage to standard medical care can help reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 participants will be randomly assigned to receive either the massage plus their usual care or jus…

This study aims to find a simple blood test to screen for a serious lung complication in people with rheumatoid arthritis (RA). Researchers will measure levels of two specific proteins (MMP7 and MMP9) in 81 participants, including RA patients with and without lung disease, and he…

This study aims to understand why some people at high risk for rheumatoid arthritis (RA) develop the full disease while others do not. Researchers will follow 150 adults, including those with early signs and family members, for two years. They will track many factors like diet, s…

This study aims to understand if harmful molecules called AGEs build up more in people with arthritis and related conditions. Researchers will use a quick, non-invasive skin scan to measure AGE levels in 300 people with various rheumatic diseases and compare them to healthy volun…

This study aims to understand how different immune cells in the blood are related to disease activity in people with various autoimmune conditions. Researchers will analyze blood samples from 500 participants, including people with diseases like lupus and rheumatoid arthritis, as…

This study aims to understand how fear of movement (kinesiophobia) affects people with rheumatoid arthritis. Researchers will compare 400 adults—200 with arthritis and 200 healthy volunteers—using questionnaires to measure fear, pain, fatigue, and disability. The goal is to learn…

This study aims to understand if a protein in the blood (called FAP) can tell doctors about disease activity and lung scarring in rheumatoid arthritis and systemic sclerosis (scleroderma). Researchers will take a single blood sample from 111 people (patients and healthy volunteer…