New drug could reverse liver scarring in MASH patients

NCT ID NCT06318169

Recruiting now Disease control Sponsor: 89bio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 6 times

Summary

This study tests a new drug, pegozafermin, in 1,350 adults with MASH (a type of fatty liver disease) and moderate liver scarring (stage F2 or F3). The goal is to see if the drug can improve scarring or resolve liver inflammation without making the disease worse over 52 weeks. Participants receive one of two doses of pegozafermin or a placebo by injection. The study is currently recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Digestive System Diseases fatty liver disease Fibrosis liver disorder metabolic disease metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASH) / NONALCOHOLIC STEATOHEPATITIS (NASH) WITH FIBROSIS

Contacts and locations

Locations

89bio Clinical Study Site
RECRUITING

Birmingham, Alabama, 35209, United States
89bio Clinical Study Site
RECRUITING

Chandler, Arizona, 85224, United States
89bio Clinical Study Site
ACTIVE_NOT_RECRUITING

Flagstaff, Arizona, 86001, United States
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Glendale, Arizona, 85036, United States
89bio Clinical Study Site
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Sun City, Arizona, 85351, United States
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Tucson, Arizona, 85712-4018, United States
89bio Clinical Study Site
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Tucson, Arizona, 85716, United States
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ACTIVE_NOT_RECRUITING

Conway, Arkansas, 72032, United States
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Little Rock, Arkansas, 72211-3859, United States
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North Little Rock, Arkansas, 72117, United States
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Canoga Park, California, 91604, United States
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Coronado, California, 92118, United States
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Escondido, California, 92025, United States
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Fountain Valley, California, 92708, United States
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Fresno, California, 93720, United States
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RECRUITING

Gardena, California, 90247, United States
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WITHDRAWN

Huntington Park, California, 90255, United States
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RECRUITING

Inglewood, California, 90301, United States
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La Jolla, California, 92037, United States
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Lancaster, California, 93534, United States
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Long Beach, California, 90815, United States
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Los Angeles, California, 90048, United States
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Montclair, California, 91763, United States
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Orange, California, 92868, United States
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WITHDRAWN

Panorama City, California, 91402, United States
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Pasadena, California, 91105, United States
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Poway, California, 92064, United States
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Rialto, California, 92377, United States
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WITHDRAWN

Santa Ana, California, 92704-5763, United States
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Stanford, California, 94305, United States
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Victorville, California, 92395, United States
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WITHDRAWN

Colorado Springs, Colorado, 80923, United States
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Littleton, Colorado, 80120, United States
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Brandon, Florida, 33511, United States
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Clermont, Florida, 34711, United States
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Fort Myers, Florida, 33912, United States
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Hialeah Gardens, Florida, 33016, United States
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Homestead, Florida, 33030, United States
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Jacksonville, Florida, 32256, United States
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Jupiter, Florida, 33458, United States
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Lady Lake, Florida, 32159-6831, United States
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WITHDRAWN

Lady Lake, Florida, 32159-8986, United States
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Lakewood Rch, Florida, 34211, United States
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Lehigh Acres, Florida, 33936, United States
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Maitland, Florida, 32751-7258, United States
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Maitland, Florida, 32751-7497, United States
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Miami, Florida, 33176, United States
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New Port Richey, Florida, 34653, United States
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Ocala, Florida, 34471, United States
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Ocoee, Florida, 34761, United States
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Sarasota, Florida, 34240, United States
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Winter Park, Florida, 32789, United States
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Athens, Georgia, 30607, United States
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Dalton, Georgia, 30720, United States
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Marietta, Georgia, 30060, United States
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Chicago, Illinois, 60611, United States
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Hammond, Indiana, 46324, United States
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New Albany, Indiana, 47150, United States
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South Bend, Indiana, 46635, United States
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Iowa City, Iowa, 52242, United States
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Topeka, Kansas, 66606, United States
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Louisville, Kentucky, 40218, United States
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Covington, Louisiana, 70433, United States
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Houma, Louisiana, 70360, United States
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Lake Charles, Louisiana, 70605, United States
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Marrero, Louisiana, 70072, United States
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ACTIVE_NOT_RECRUITING

New Orleans, Louisiana, 70115, United States
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West Monroe, Louisiana, 71291, United States
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Baltimore, Maryland, 21202, United States
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Glen Burnie, Maryland, 21061, United States
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Greenbelt, Maryland, 20770, United States
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Burlington, Massachusetts, 01805, United States
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Chesterfield, Michigan, 48047, United States
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Wyoming, Michigan, 49519, United States
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Ypsilanti, Michigan, 48197, United States
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Maplewood, Minnesota, 55109, United States
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Rochester, Minnesota, 55905, United States
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Flowood, Mississippi, 39232, United States
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St Louis, Missouri, 63123, United States
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Las Vegas, Nevada, 89106, United States
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WITHDRAWN

Florham Park, New Jersey, 07932, United States
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Freehold, New Jersey, 07728, United States
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Warren Township, New Jersey, 07059, United States
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Albuquerque, New Mexico, 87109, United States
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Albany, New York, 12206, United States
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Carmel, New York, 10512, United States
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New York, New York, 10021, United States
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WITHDRAWN

New York, New York, 10033, United States
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Charlotte, North Carolina, 28207, United States
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Durham, North Carolina, 27710, United States
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Fayetteville, North Carolina, 28304, United States
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Morehead City, North Carolina, 28557, United States
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Raleigh, North Carolina, 27612, United States
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Wilmington, North Carolina, 28401, United States
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Winston-Salem, North Carolina, 27103, United States
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Akron, Ohio, 44320, United States
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ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44106, United States
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Dayton, Ohio, 45145, United States
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Dayton, Ohio, 45414, United States
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Liberty Township, Ohio, 45044, United States
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Lima, Ohio, 45801, United States
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Springboro, Ohio, 45066, United States
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Westlake, Ohio, 44145, United States
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East Greenwich, Rhode Island, 02818, United States
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Charleston, South Carolina, 29425, United States
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Columbia, South Carolina, 29204, United States
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Chattanooga, Tennessee, 37421, United States
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Cordova, Tennessee, 38018, United States
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Hermitage, Tennessee, 37076, United States
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Nashville, Tennessee, 37211, United States
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Amarillo, Texas, 79106, United States
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Austin, Texas, 78745, United States
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Austin, Texas, 78757-8051, United States
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Austin, Texas, 78757, United States
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Bellaire, Texas, 77401, United States
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Brownsville, Texas, 78520, United States
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Corpus Christi, Texas, 78404, United States
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Denton, Texas, 76201, United States
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DeSoto, Texas, 75115, United States
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Edinburg, Texas, 78539, United States
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Farmers Branch, Texas, 75234, United States
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WITHDRAWN

Fort Sam Houston, Texas, 78234, United States
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RECRUITING

Fort Worth, Texas, 76104, United States
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RECRUITING

Garland, Texas, 75044, United States
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Georgetown, Texas, 78626, United States
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Georgetown, Texas, 78628, United States
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Houston, Texas, 77030, United States
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RECRUITING

Houston, Texas, 77090, United States
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RECRUITING

Houston, Texas, 77099, United States
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RECRUITING

Katy, Texas, 77494, United States
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RECRUITING

Lewisville, Texas, 75067, United States
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RECRUITING

Lubbock, Texas, 79424, United States
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San Antonio, Texas, 78209, United States
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RECRUITING

San Antonio, Texas, 78215, United States
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RECRUITING

San Antonio, Texas, 78222, United States
89bio Clinical Study Site
RECRUITING

San Antonio, Texas, 78229-4801, United States
89bio Clinical Study Site
RECRUITING

San Antonio, Texas, 78229, United States
89bio Clinical Study Site
RECRUITING

Southlake, Texas, 76092, United States
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RECRUITING

Stafford, Texas, 77477, United States
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RECRUITING

Sugar Land, Texas, 77479, United States
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Tomball, Texas, 77584, United States
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RECRUITING

Tyler, Texas, 75701, United States
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RECRUITING

Waco, Texas, 76301, United States
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RECRUITING

Waco, Texas, 76710, United States
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RECRUITING

Ogden, Utah, 84405, United States
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RECRUITING

Richmond, Virginia, 23226-1925, United States
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ACTIVE_NOT_RECRUITING

Richmond, Virginia, 23229, United States
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RECRUITING

Richmond, Virginia, 23236, United States
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RECRUITING

Richmond, Virginia, 23298, United States
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RECRUITING

Roanoke, Virginia, 24014, United States
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RECRUITING

Bellevue, Washington, 98004, United States
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RECRUITING

Seattle, Washington, 98101, United States
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RECRUITING

Seattle, Washington, 98105, United States
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RECRUITING

Tacoma, Washington, 98405, United States
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Buenos Aires, 1061, Argentina
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RECRUITING

Buenos Aires, 1125, Argentina
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RECRUITING

Buenos Aires, 1181, Argentina
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WITHDRAWN

Buenos Aires, C1012AAR, Argentina
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RECRUITING

Buenos Aires, C1425, Argentina
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RECRUITING

Caba, C1430CKE, Argentina
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Capital Federal, C1280AEB, Argentina
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Pilar, 1629, Argentina
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Brisbane, Queensland, 4120, Australia
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Herston, Queensland, 4019, Australia
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South Brisbane, Queensland, 4101, Australia
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RECRUITING

Adelaide, South Australia, 5000, Australia
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Bedford Park, South Australia, 5042, Australia
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Clayton, Victoria, 3168, Australia
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Heidelberg, Victoria, 3084, Australia
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Perth, Western Australia, 6000, Australia
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Fitzroy, 3065, Australia
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Murdoch, 6150, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Klagenfurt, 9020, Austria
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Sankt Pölten, 3100, Austria
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Wels, 4600, Austria
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ACTIVE_NOT_RECRUITING

Brussels, 1020, Belgium
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Brussels, 1070, Belgium
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Edegem, 2650, Belgium
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Genk, 3600, Belgium
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Ghent, 9000, Belgium
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RECRUITING

Jette, 1090, Belgium
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WITHDRAWN

Gorna Oryahovitsa, 5100, Bulgaria
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WITHDRAWN

Sofia, 1202, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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WITHDRAWN

Stara Zagora, 6003, Bulgaria
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Calgary, Alberta, T2N 4Z6, Canada
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Vancouver, British Columbia, V5Z 1M9, Canada
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Vancouver, British Columbia, V6Z2K5, Canada
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Winnipeg, Manitoba, R3T 2N2, Canada
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London, Ontario, N6A 5A5, Canada
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Ottawa, Ontario, K1H8L6, Canada
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Toronto, Ontario, M5G2C4, Canada
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Toronto, Ontario, M6H 3M1, Canada
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Vaughan, Ontario, L4L 4Y7, Canada
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Brno, 625 00, Czechia
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Ostrava, 708 52, Czechia
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WITHDRAWN

Pilsen, 30100, Czechia
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Amiens, 80080, France
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Angers, 49933, France
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Bordeaux, 33604, France
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Lille, 59000, France
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Limoges, 87042, France
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Lyon, 69004, France
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Montpellier, 34090, France
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Nantes, 44093, France
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Nice, 06200, France
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Paris, 75012, France
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Paris, 75013, France
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Paris, 75014, France
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Pierre-Bénite, 69310, France
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Strasbourg, 67000, France
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Toulouse, 31076, France
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Toulouse, France
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Vandœuvre-lès-Nancy, 54500, France
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Vénissieux, 69200, France
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Villejuif, 94800, France
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Batumi, 6000, Georgia
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WITHDRAWN

Batumi, 6010, Georgia
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Tbilisi, 0159, Georgia
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Tbilisi, 0177, Georgia
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Chemnitz, 09116, Germany
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Frankfurt am Main, 60596, Germany
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Freiburg im Breisgau, 79106, Germany
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Hanover, 30625, Germany
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Homburg, 66421, Germany
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Münster, 48149, Germany
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Hong Kong, 0000, Hong Kong
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Shatin, 0000, Hong Kong
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Guwahati, Assam, 701032, India
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Allahābād, Uttar Pradesh, 211002, India
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Kolkata, West Bengal, 700150, India
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Bhubaneswar, 751024, India
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Gujrāt, 360001, India
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Nagpur, 440012, India
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New Delhi, 110029, India
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Surat, 395009, India
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Wardha, 442004, India
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Afula, 1834111, Israel
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Beersheba, 8410500, Israel
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Haifa, 3109601, Israel
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Haifa, 3436212, Israel
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Jerusalem, Israel
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Nahariya, 2210001, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 6971014, Israel
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Tel Aviv, Israel
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Bergamo, 24127, Italy
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Foggia, 71121, Italy
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Milan, 20089, Italy
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Milan, 20152, Italy
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Milan, 20162, Italy
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Modena, 41126, Italy
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Naples, 80131, Italy
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Novara, 28100, Italy
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Palermo, 90127, Italy
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Roma, 00128, Italy
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Rome, 00136, Italy
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Rome, 169, Italy
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Torino, 10126, Italy
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Maebashi, Gunma, 371-0821, Japan
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Sapporo, Hokkaido, 065-0012, Japan
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Hizume, Iwate, 028-3695, Japan
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Kawasaki, Kanagawa, 215-0026, Japan
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Yokohama, Kanagawa, 236-004, Japan
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Ehime, 791-0295, Japan
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Ehime, 798-8510, Japan
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Fukuoka, 814-0180, Japan
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Gifu, 500-8323, Japan
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Kumamoto, 862-0971, Japan
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Nagano, 381-0006, Japan
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Okayama, 700-8558, Japan
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Osaka, 545-0051, Japan
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Osaka, 564-0013, Japan
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Saga, 849-0937, Japan
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Sapporo, 062-0921, Japan
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Chihuahua City, 31217, Mexico
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Cuautitlán Izcalli, 54769, Mexico
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Jalisco, 44130, Mexico
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Mexico City, 03330, Mexico
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Mexico City, 06700, Mexico
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Morelos, 62270, Mexico
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Nuevo León, 64310, Mexico
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Yucatán, 97070, Mexico
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Rotterdam, South Holland, 3015C, Netherlands
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Amsterdam, 1081HV, Netherlands
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Utrecht, 3584CX, Netherlands
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WITHDRAWN

Katowice, 40-752, Poland
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Krakow, 31-501, Poland
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Lodz, 90-302, Poland
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Lodz, 91-363, Poland
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Mysłowice, 41-400, Poland
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Warsaw, 00-215, Poland
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Warsaw, 02-172, Poland
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Warsaw, 04-501, Poland
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Wroclaw, 53-673, Poland
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Manati, 00674, Puerto Rico
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Mayagüez, 00680, Puerto Rico
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San Juan, 00927, Puerto Rico
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Singapore, 119228, Singapore
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Singapore, 169856, Singapore
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Singapore, 308433, Singapore
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Singapore, 529889, Singapore
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Cape Town, 7530, South Africa
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RECRUITING

Johannesburg, 2196, South Africa
89bio Clinical Study Site
RECRUITING

Worcester, 6850, South Africa
89bio Clinical Study Site
RECRUITING

Busan, 49241, South Korea
89bio Clinical Study Site
RECRUITING

Daegu, 42415, South Korea
89bio Clinical Study Site
RECRUITING

Gyeonggi-do, 16247, South Korea
89bio Clinical Study Site
RECRUITING

Incheon, 22332, South Korea
89bio Clinical Study Site
RECRUITING

Seoul, 02447, South Korea
89bio Clinical Study Site
RECRUITING

Seoul, 03080, South Korea
89bio Clinical Study Site
RECRUITING

Seoul, 06591, South Korea
89bio Clinical Study Site
RECRUITING

Seoul, 07061, South Korea
89bio Clinical Study Site
RECRUITING

Seoul, 07985, South Korea
89bio Clinical Study Site
RECRUITING

Seoul, 08308, South Korea
89bio Clinical Study Site
RECRUITING

Barcelona, 08003, Spain
89bio Clinical Study Site
RECRUITING

Barcelona, 08035, Spain
89bio Clinical Study Site
RECRUITING

Barcelona, 08036, Spain
89bio Clinical Study Site
RECRUITING

Barcelona, 08041, Spain
89bio Clinical Study Site
RECRUITING

Barcelona, 08916, Spain
89bio Clinical Study Site
RECRUITING

Córdoba, 14004, Spain
89bio Clinical Study Site
RECRUITING

Madrid, 28007, Spain
89bio Clinical Study Site
RECRUITING

Majadahonda, 28222, Spain
89bio Clinical Study Site
WITHDRAWN

Málaga, 29010, Spain
89bio Clinical Study Site
RECRUITING

Pontevedra, 36071, Spain
89bio Clinical Study Site
RECRUITING

Santander, 39008, Spain
89bio Clinical Study Site
RECRUITING

Santiago de Compostela, 15706, Spain
89bio Clinical Study Site
RECRUITING

Seville, 41013, Spain
89bio Clinical Study Site
RECRUITING

Chiayi City, 60002, Taiwan
89bio Clinical Study Site
RECRUITING

Kaohsiung City, 807, Taiwan
89bio Clinical Study Site
RECRUITING

Taipei, 100225, Taiwan
89bio Clinical Study Site
RECRUITING

Adana, 1370, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Ankara, 06230, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Ankara, 06800, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Bursa, 16110, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Center, 53020, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Fatih, 34093, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Gaziantep, 27410, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Istanbul, 34899, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Izmir, 35360, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

Sarıçam, 01790, Turkey (Türkiye)
89bio Clinical Study Site
ACTIVE_NOT_RECRUITING

Umraniye, 34764, Turkey (Türkiye)
89bio Clinical Study Site
RECRUITING

High Wycombe, Buckinghamshire, HP11 2QW, United Kingdom
89bio Clinical Study Site
RECRUITING

Bristol, BS6 6LT, United Kingdom
89bio Clinical Study Site
RECRUITING

Glasgow, G514TY, United Kingdom
89bio Clinical Study Site
WITHDRAWN

Hull, HU3 2JZ, United Kingdom
89bio Clinical Study Site
RECRUITING

London, E13 8SL, United Kingdom
89bio Clinical Study Site
RECRUITING

London, E1, United Kingdom
89bio Clinical Study Site
RECRUITING

London, NW32QG, United Kingdom
89bio Clinical Study Site
RECRUITING

London, SE5 9RS, United Kingdom
89bio Clinical Study Site
RECRUITING

London, W2 1NY, United Kingdom
89bio Clinical Study Site
RECRUITING

Oxford, OX3 9DU, United Kingdom
89bio Clinical Study Site
RECRUITING

Portsmouth, PO6 3LY, United Kingdom
89bio Clinical Study Site
RECRUITING

Preston, PR2 9QB, United Kingdom
89bio Clinical Study Site
RECRUITING

Southampton, SO16 6YD, United Kingdom
89bio Clinical Study Site
RECRUITING

Stockton, TS19, United Kingdom
89bio Clinical Study Site
RECRUITING

Sunderland, SR4 7TP, United Kingdom
89bio Clinical Study Site
RECRUITING

Swansea, SA6, United Kingdom
89bio Clinical Study Site
RECRUITING

York, YO24 4LJ, United Kingdom
89bio_Clinical Study Site
RECRUITING

Tbilisi, 0159, Georgia