New drug aims to reverse liver damage in MASH cirrhosis

NCT ID NCT06419374

Recruiting now Disease control Sponsor: 89bio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 6 times

Summary

This Phase 3 study tests an experimental drug called pegozafermin in 762 adults with liver scarring (cirrhosis) caused by MASH, a fatty liver disease. Participants receive weekly injections of the drug or a placebo for about two years. The goal is to see if the drug can improve liver scarring and prevent serious liver problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pegozafermin (a biologic injection)
What this could lead to: If it works, this could provide a treatment that slows or reverses liver scarring and reduces the risk of serious liver complications in people with MASH cirrhosis.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may not prove effective, and side effects from the biologic injection are possible. Results will take several years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Digestive System Diseases fatty liver disease Fibrosis liver disorder metabolic disease metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH) / NONALCOHOLIC STEATOHEPATITIS (NASH) WITH COMPENSATED CIRRHOSIS

Contacts and locations

Locations

89bio Clinical Study Site
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Brussels, 01090, Belgium
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Brussels, 1200, Belgium
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Edegem, 02650, Belgium
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Genk, 03600, Belgium
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Ghent, 09000, Belgium
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Roeselare, 08800, Belgium
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Barretos, 14784-400, Brazil
89bio Clinical Study Site
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Belo Horizonte, 30220-140, Brazil
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Botucatu, 18618-687, Brazil
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Brasília, 71625009, Brazil
89bio Clinical Study Site
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Goiânia, 74605-050, Brazil
89bio Clinical Study Site
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Porto Alegre, 90035-903, Brazil
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Rio de Janeiro, 21941-617, Brazil
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Salvador, 41820-460, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04038-002, Brazil
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Vitória, 29055-450, Brazil
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Gorna Oryahovitsa, 05100, Bulgaria
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Sofia, 01202, Bulgaria
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Sofia, 01407, Bulgaria
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Stara Zagora, 06003, Bulgaria
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Calgary, Alberta, T2N 4Z6, Canada
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Vancouver, British Columbia, V5Z 1M9, Canada
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Vancouver, British Columbia, V6Z2K5, Canada
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Winnipeg, Manitoba, R3E 3P4, Canada
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London, Ontario, N6A5A5, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M6H3M1, Canada
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Vaughan, L4L 4Y7, Canada
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Amiens, 80054, France
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Dijon, 21000, France
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Limoges, 87000, France
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Lyon, 69004, France
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Montpellier, 34295, France
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Nice, 06202, France
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Paris, 75012, France
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Paris, 75013, France
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Paris, 75014, France
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Pessac, 33604, France
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Strasbourg, 67091, France
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Toulouse, 31400, France
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Vandœuvre-lès-Nancy, 54500, France
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Vénissieux, 69694, France
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Villejuif, 94800, France
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Tbilisi, 0159, Georgia
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Tbilisi, 0177, Georgia
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Chemnitz, 9116, Germany
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Frankfurt, 60590, Germany
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Freiburg im Breisgau, 79110, Germany
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Hanover, 30625, Germany
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Homburg, 66421, Germany
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Münster, 48149, Germany
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Hong Kong, Hong Kong
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Shatin, Hong Kong
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Budapest, 01027, Hungary
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Budapest, 01088, Hungary
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Budapest, H-1097, Hungary
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Gujrāt, 360001, India
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Rajpur Sonarpur, 700150, India
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Sūrat, 395009, India
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Wardha, 442004, India
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Afula, 1834111, Israel
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Beersheba, 8410101, Israel
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Haifa, 3109601, Israel
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ENROLLING_BY_INVITATION

Haifa, 3436212, Israel
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Jerusalem, 9112001, Israel
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Nahariya, 2210001, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 69710, Israel
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Tel Litwinsky, 5265601, Israel
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Bergamo, 24127, Italy
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Foggia, 71121, Italy
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Milan, 20122, Italy
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Milan, 20162, Italy
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Novara, 28100, Italy
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Palermo, 90127, Italy
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Roma, 00128, Italy
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Rome, 00168, Italy
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Rozzano, 20089, Italy
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Torino, 10124, Italy
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Chihuahua City, 31217, Mexico
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Cuautitlán Izcalli, CP 54769, Mexico
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Cuernavaca, 62250, Mexico
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Jalisco, 44130, Mexico
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Mexico City, 03330, Mexico
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Mexico City, 06700, Mexico
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Mérida, 97070, Mexico
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Monterrey, 64310, Mexico
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Amsterdam, 1081 HV, Netherlands
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Rotterdam, 3015GD, Netherlands
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Tilburg, 5022 GC, Netherlands
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Utrecht, 3584 CX, Netherlands
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Katowice, 40-752, Poland
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Krakow, 31-501, Poland
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Lodz, 90-302, Poland
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Lodz, 91-363, Poland
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Mysłowice, 41-400, Poland
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Warsaw, 00-215, Poland
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Warsaw, 02-172, Poland
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Warsaw, 04-501, Poland
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Wroclaw, 53-673, Poland
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Manati, 00674, Puerto Rico
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Mayagüez, 00680, Puerto Rico
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San Juan, 00927, Puerto Rico
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Singapore, 119074, Singapore
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Singapore, 169608, Singapore
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Singapore, 308433, Singapore
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Singapore, 529889, Singapore
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Bucheon-si, 14584, South Korea
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Busan, 49241, South Korea
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Daegu, 42415, South Korea
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Daegu, 700-712, South Korea
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Incheon, 22332, South Korea
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Seoul, 03080, South Korea
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Seoul, 06591, South Korea
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Seoul, 07061, South Korea
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Seoul, 07895, South Korea
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Seoul, 130-872, South Korea
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Almería, 04009, Spain
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Badalona, 08916, Spain
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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Barcelona, 08041, Spain
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Córdoba, 14004, Spain
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Madrid, 28007, Spain
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Málaga, 29010, Spain
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Pontevedra, 36071, Spain
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Santander, 39008, Spain
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Santiago de Compostela, 15706, Spain
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Zaragoza, 50009, Spain
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Chiayi City, 60002, Taiwan
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Kaohsiung City, 80756, Taiwan
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Tainan, 00704, Taiwan
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Bornova, İzmir, 35040, Turkey (Türkiye)
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Merkez, Rize Province, 53020, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 6800, Turkey (Türkiye)
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Fatih, 34093, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35360, Turkey (Türkiye)
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Sarıçam, 01790, Turkey (Türkiye)
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Umraniye, 34764, Turkey (Türkiye)
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Yüreğir, 1370, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Bristol, BS10 5NB, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, E1 1BB, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE5 9RS, United Kingdom
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London, W2 1NY, United Kingdom
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Oxford, OX3 9DU, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Port Talbot, SA12 7BR, United Kingdom
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Portsmouth, P06 3LY, United Kingdom
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Southampton, SO16 6YD, United Kingdom
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Athens, Georgia, 30607, United States
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Atlanta, Georgia, 30309, United States
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Chicago, Illinois, 60611, United States
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Glenview, Illinois, 60026, United States
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Hammond, Indiana, 46324, United States
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New Albany, Indiana, 47150, United States
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South Bend, Indiana, 46635, United States
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Iowa City, Iowa, 52242, United States
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Kansas City, Kansas, 66160, United States
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Topeka, Kansas, 66606, United States
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Louisville, Kentucky, 40218, United States
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Lafayette, Louisiana, 70503, United States
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Lake Charles, Louisiana, 70605, United States
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West Monroe, Louisiana, 71291, United States
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Baltimore, Maryland, 21202, United States
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Glen Burnie, Maryland, 21061, United States
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Greenbelt, Maryland, 20770, United States
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Burlington, Massachusetts, 01805, United States
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Ann Arbor, Michigan, 48109, United States
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Clinton Township, Michigan, 48038, United States
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Detroit, Michigan, 48202, United States
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Wyoming, Michigan, 49519, United States
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Ypsilanti, Michigan, 48197, United States
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Minneapolis, Minnesota, 55413, United States
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Rochester, Minnesota, 55905, United States
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Flowood, Mississippi, 39232, United States
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Tupelo, Mississippi, 38801, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63123, United States
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Las Vegas, Nevada, 89106, United States
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WITHDRAWN

Florham Park, New Jersey, 07932, United States
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Somers Point, New Jersey, 08244, United States
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Albuquerque, New Mexico, 87109, United States
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New York, New York, 10016, United States
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New York, New York, 10021, United States
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WITHDRAWN

New York, New York, 10033, United States
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Asheville, North Carolina, 28801, United States
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Charlotte, North Carolina, 28207, United States
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Durham, North Carolina, 27710, United States
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Fayetteville, North Carolina, 28304, United States
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WITHDRAWN

Greenville, North Carolina, 27834, United States
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Winston-Salem, North Carolina, 27103, United States
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Akron, Ohio, 44320, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44106, United States
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Columbus, Ohio, 43210, United States
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Dayton, Ohio, 45145, United States
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Dayton, Ohio, 45414, United States
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Liberty Township, Ohio, 45044, United States
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Westlake, Ohio, 44145, United States
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Philadelphia, Pennsylvania, 19148, United States
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Pittsburgh, Pennsylvania, 15213, United States
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East Greenwich, Rhode Island, 02818, United States
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Charleston, South Carolina, 29425, United States
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Columbia, South Carolina, 29204, United States
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Rapid City, South Dakota, 57701, United States
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Cordova, Tennessee, 38018, United States
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Hermitage, Tennessee, 37076, United States
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Nashville, Tennessee, 37211, United States
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Amarillo, Texas, 79106, United States
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Austin, Texas, 78745, United States
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Austin, Texas, 78757-8059, United States
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Austin, Texas, 78757-8066, United States
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Brownsville, Texas, 78520, United States
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DeSoto, Texas, 75115, United States
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TERMINATED

Edinburg, Texas, 78539, United States
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Farmers Branch, Texas, 75234, United States
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Fort Worth, Texas, 76104, United States
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Georgetown, Texas, 78628, United States
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Harlingen, Texas, 78550, United States
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Houston, Texas, 77030, United States
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WITHDRAWN

Houston, Texas, 77074, United States
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Houston, Texas, 77090, United States
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RECRUITING

Houston, Texas, 77099, United States
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Lewisville, Texas, 75067, United States
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WITHDRAWN

Lubbock, Texas, 79410, United States
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Lubbock, Texas, 79424, United States
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Mansfield, Texas, 76063, United States
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WITHDRAWN

Pearland, Texas, 77584, United States
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San Antonio, Texas, 78209, United States
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San Antonio, Texas, 78229-4801, United States
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San Antonio, Texas, 78229-5069, United States
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San Marcos, Texas, 78666, United States
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Southlake, Texas, 76092, United States
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Tyler, Texas, 75701, United States
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Waco, Texas, 76710, United States
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Waco, Texas, 76712, United States
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Sandy City, Utah, 84092, United States
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West Jordan, Utah, 84088, United States
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Richmond, Virginia, 23226, United States
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WITHDRAWN

Richmond, Virginia, 23229, United States
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Richmond, Virginia, 23236, United States
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Richmond, Virginia, 23298, United States
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Bellevue, Washington, 98004, United States
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Seattle, Washington, 98101, United States
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Seattle, Washington, 98105, United States
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Tacoma, Washington, 98405, United States
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Buenos Aires, C1012AAR, Argentina
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Buenos Aires, C1125ABE, Argentina
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Buenos Aires, C1199ABB, Argentina
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Buenos Aires, C1425BGH, Argentina
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Buenos Aires, C1425, Argentina
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Buenos Aires, CP 1061, Argentina
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CABA, C1430CKE, Argentina
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Capital Federal, C1280AEB, Argentina
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Pilar, B1629AHJ, Argentina
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Adelaide, SA 5000, Australia
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Fitzroy, 03065, Australia
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Greenslopes, 04120, Australia
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Heidelberg, 3084, Australia
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Herston, Qld 4029, Australia
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Murdoch, 06150, Australia
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Perth, 06000, Australia
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South Brisbane, 04101, Australia
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Brussels, 01070, Belgium
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Birmingham, Alabama, 35205, United States
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Homewood, Alabama, 35209, United States
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Chandler, Arizona, 85224, United States
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WITHDRAWN

Flagstaff, Arizona, 86001, United States
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Peoria, Arizona, 85381, United States
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Phoenix, Arizona, 85054, United States
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Sun City, Arizona, 85351, United States
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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85715, United States
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Tucson, Arizona, 85716, United States
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Little Rock, Arkansas, 72205, United States
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North Little Rock, Arkansas, 72117, United States
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Camarillo, California, 93012, United States
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Canoga Park, California, 91304, United States
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Coronado, California, 92118, United States
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Fountain Valley, California, 92708, United States
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Fresno, California, 93720, United States
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WITHDRAWN

Huntington Park, California, 90255, United States
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La Jolla, California, 92037-0887, United States
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Los Angeles, California, 90033, United States
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Los Angeles, California, 90048, United States
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Pasadena, California, 91105, United States
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Poway, California, 92064, United States
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Redwood City, California, 94063, United States
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Rialto, California, 92377, United States
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Sacramento, California, 95817, United States
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WITHDRAWN

Santa Ana, California, 92704, United States
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Littleton, Colorado, 80120, United States
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Clermont, Florida, 34711, United States
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Fort Myers, Florida, 33912, United States
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Gainesville, Florida, 32610, United States
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Hialeah Gardens, Florida, 33016, United States
89bio Clinical Study Site
RECRUITING

Homestead, Florida, 33030, United States
89bio Clinical Study Site
RECRUITING

Jacksonville, Florida, 32224, United States
89bio Clinical Study Site
RECRUITING

Jacksonville, Florida, 32256, United States
89bio Clinical Study Site
WITHDRAWN

Lady Lake, Florida, 32159, United States
89bio Clinical Study Site
RECRUITING

Lakewood Rch, Florida, 34211, United States
89bio Clinical Study Site
RECRUITING

Lehigh Acres, Florida, 33936, United States
89bio Clinical Study Site
RECRUITING

Maitland, Florida, 32751, United States
89bio Clinical Study Site
RECRUITING

Miami, Florida, 33144, United States
89bio Clinical Study Site
RECRUITING

Miami, Florida, 33176-1530, United States
89bio Clinical Study Site
WITHDRAWN

Miami, Florida, 33176-7947, United States
89bio Clinical Study Site
RECRUITING

Miami, Florida, 33176, United States
89bio Clinical Study Site
RECRUITING

New Port Richey, Florida, 34653, United States
89bio Clinical Study Site
RECRUITING

Ocala, Florida, 34471, United States
89bio Clinical Study Site
RECRUITING

Ocoee, Florida, 34761, United States
89bio Clinical Study Site
TERMINATED

Orlando, Florida, 32825, United States
89bio Clinical Study Site
RECRUITING

University Park, Florida, 34201, United States
89bio Clinical Study Site
RECRUITING

Viera, Florida, 32940, United States
89bio Clinical Study Site
RECRUITING

Winter Park, Florida, 32789, United States

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