Can a targeted therapy tame rare kidney diseases in daily practice?

NCT ID NCT07746895

Recruiting now Disease control Sponsor: Swedish Orphan Biovitrum Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study looks at how well the medication pegcetacoplan works and how safe it is for people with two rare kidney conditions: C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). Researchers will follow about 150 patients who are already receiving or planning to receive pegcetacoplan in real-world settings, not in a controlled trial. They will track urine protein levels and other biomarkers to see if the drug helps control the disease and to better understand its long-term benefits and risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pegcetacoplan, an infused medication for subcutaneous use
What this could lead to: If successful, this study could provide stronger evidence that pegcetacoplan helps control protein loss in urine and manage these rare kidney diseases in everyday practice.
What could go wrong: This is an observational real-world study, not a controlled trial, so results may be influenced by patient differences. The medication may not work for everyone and could have side effects.

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Conditions

The condition(s) this trial relates to.

complement 3 glomerulopathy glomerulonephritis immunoglobulin-mediated membranoproliferative glomerulonephritis Rare Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C3 GLOMERULOPATHY (C3G) IMMUNE COMPLEX MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (IC-MPGN)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AP-HP Georges-Pompidou European Hospital (Paris)
NOT_YET_RECRUITING

Paris, 75015, France
Allgemeines Krankenhaus Wien Universitätsklinik
NOT_YET_RECRUITING

Vienna, 1090, Austria
Azienda Ospedaliera Universitaria Gaetano Martino
NOT_YET_RECRUITING

Messina, 98123, Italy
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
NOT_YET_RECRUITING

Bologna, 40138, Italy
Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
NOT_YET_RECRUITING

Bari, 70124, Italy
Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi
NOT_YET_RECRUITING

Bologna, 40138, Italy
Azienda Ospedaliero-Universitaria Santa Maria della Misericordia
NOT_YET_RECRUITING

Udine, 33100, Italy
British Columbia Childrens' & Women's Hospital Center
NOT_YET_RECRUITING

Vancouver, British Columbia, V6H 3V4, Canada
CHU Bordeaux
NOT_YET_RECRUITING

Bordeaux, 33076, France
CHU Lyon - Hôpital Femme-Mère-Enfant
NOT_YET_RECRUITING

Bron, 69500, France
CHU Nantes - Hôtel Dieu
NOT_YET_RECRUITING

Nantes, 44000, France
CHU Reims - Hôpital Maison Blanche
NOT_YET_RECRUITING

Reims, 51200, France
CHU Sainte-Justine
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1C5, Canada
CHU Strasbourg - Nouvel Hôpital Civil
NOT_YET_RECRUITING

Strasbourg, 67000, France
CHU UCL Namur
NOT_YET_RECRUITING

Namur, 5000, Belgium
CHUV, Lausanne University Hospital
NOT_YET_RECRUITING

Lausanne, 1005, Switzerland
Cambridge University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Cambridge, CB2 2QQ, United Kingdom
Centre Hospitalier Universitaire de Liege
NOT_YET_RECRUITING

Liège, 4000, Belgium
Charité - Campus Virchow-Klinikum
NOT_YET_RECRUITING

Berlin, 13355, Germany
Chungnam National University Hospital
NOT_YET_RECRUITING

Daejeon, 35015, South Korea
Cliniques Universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, 1200, Belgium
Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, 15006, Spain
Evelina London Children's Hospital
NOT_YET_RECRUITING

London, SE1 7EH, United Kingdom
Fakultni nemocnice v Motole
NOT_YET_RECRUITING

Prague, 16900, Czechia
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
NOT_YET_RECRUITING

Milan, 20122, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
NOT_YET_RECRUITING

Roma, 168, Italy
Grand Hôpital de Charleroi
NOT_YET_RECRUITING

Gilly, 6060, Belgium
Hopital Claude Huriez - CHU Lille
NOT_YET_RECRUITING

Lille, 59000, France
Hopital Henri Mondor
NOT_YET_RECRUITING

Créteil, 94000, France
Hopital Lapeyronie pt
NOT_YET_RECRUITING

Montpellier, 34090, France
Hopital de la Conception - APHM
NOT_YET_RECRUITING

Marseille, 13005, France
Hospital Clinic de Barcelona
NOT_YET_RECRUITING

Barcelona, 8036, Spain
Hospital Doctor Peset Valencia
NOT_YET_RECRUITING

Valencia, 46017, Spain
Hospital General Universitario Gregorio Marañon
NOT_YET_RECRUITING

Madrid, 28007, Spain
Hospital La Paz
NOT_YET_RECRUITING

Madrid, 28046, Spain
Hospital Regional Universitario de Malaga
NOT_YET_RECRUITING

Málaga, 29010, Spain
Hospital Sant Joan de Deu
NOT_YET_RECRUITING

Barcelona, 8950, Spain
Hospital Universitari Vall d'Hebron - VHIR
NOT_YET_RECRUITING

Barcelona, 8024, Spain
Hospital Universitari i Politecnic La Fe
NOT_YET_RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, 28041, Spain
Hospital Universitario de la Palma
NOT_YET_RECRUITING

Las Palmas, 35003, Spain
Hôpital Foch
NOT_YET_RECRUITING

Suresnes, 92150, France
Hôpital Necker - Enfants Malades
NOT_YET_RECRUITING

Paris, 75015, France
Hôpital Robert Debré - Paris
NOT_YET_RECRUITING

Paris, 75019, France
Hôpital Saint-Louis
NOT_YET_RECRUITING

Paris, 75010, France
Hôpitaux Universitaires de Genève - HUG
NOT_YET_RECRUITING

Geneva, 1205, Switzerland
Imperial College Healthcare NHS Trust (ICH)
NOT_YET_RECRUITING

London, W12 0HS, United Kingdom
Inselspital - University Hospital Bern
NOT_YET_RECRUITING

Bern, 3010, Switzerland
Institut klinicke a experimentalni mediciny
NOT_YET_RECRUITING

Prague, 14021, Czechia
Keimyung University Dongsan Hospital
NOT_YET_RECRUITING

Daegu, 42601, South Korea
King Fahad Medical City
NOT_YET_RECRUITING

Riyadh, 11525, Saudi Arabia
King Faisal Specialist Hospital & Research Center
NOT_YET_RECRUITING

Jeddah, 66697, Saudi Arabia
King Faisal Specialist Hospital & Research Center
NOT_YET_RECRUITING

Riyadh, 11211, Saudi Arabia
Kingston General Hospital
NOT_YET_RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Klinik Ottakring
NOT_YET_RECRUITING

Vienna, 1140, Austria
Leicester General Hospital
NOT_YET_RECRUITING

Leicester, LE1 7RH, United Kingdom
London Health Sciences Centre (LHSC) - Victoria Hospital
NOT_YET_RECRUITING

London, Ontario, N6A 5W9, Canada
McGill University
NOT_YET_RECRUITING

Montreal, Quebec, H3G 1A4, Canada
Medizinische Hochschule Hannover
NOT_YET_RECRUITING

Hanover, 30625, Germany
Medizinische Universität Graz
NOT_YET_RECRUITING

Graz, 8010, Austria
Nepean Hospital
NOT_YET_RECRUITING

Kingswood, 2747, Australia
Nephrologisches Zentrum Villingen-Schwenningen
NOT_YET_RECRUITING

Villingen-Schwenningen, 78052, Germany
Newcastle Hospital NHS Foundation Trust
NOT_YET_RECRUITING

Newcastle, NE1 4LP, United Kingdom
Nierenzentrum Wiesbaden
NOT_YET_RECRUITING

Wiesbaden, 65191, Germany
Ospedale Pediatrico Bambino Gesù
NOT_YET_RECRUITING

Roma, 165, Italy
Ospedali Riuniti di Foggia
NOT_YET_RECRUITING

Foggia, 71100, Italy
Princess Alexandra Hospital
NOT_YET_RECRUITING

Woolloongabba, 4102, Australia
Robert-Bosch-Krankenhaus
NOT_YET_RECRUITING

Stuttgart, 70376, Germany
Royal Free Hospital
NOT_YET_RECRUITING

London, NW3 2QG, United Kingdom
Royal Hospital for Children
NOT_YET_RECRUITING

Glasgow, G51 4TF, United Kingdom
Royal Manchester Children's Hospital
NOT_YET_RECRUITING

Manchester, M13 9WL, United Kingdom
Salford Care Organisation
NOT_YET_RECRUITING

Salford, M8 8HD, United Kingdom
Samsung Medical Center
NOT_YET_RECRUITING

Seoul, 6351, South Korea
Seoul Metropolitan Government Seoul National University Boramae Medical Center
NOT_YET_RECRUITING

Seoul, 7061, South Korea
Seoul National University Bundang Hospital
NOT_YET_RECRUITING

Seongnam, 13597, South Korea
Seoul National University Hospital
NOT_YET_RECRUITING

Seoul, 3080, South Korea
Severance Hospital, Yonsei University Health System
NOT_YET_RECRUITING

Seoul, 3722, South Korea
Taipei Veterans General Hospital
NOT_YET_RECRUITING

Taipei, 11217, Taiwan
Tenon CHU Paris Est
NOT_YET_RECRUITING

Paris, 75020, France
The Catholic University of Korea, Seoul St. Mary's Hospital
NOT_YET_RECRUITING

Seoul, 6591, South Korea
The Hospital for Sick Children
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1E8, Canada
UZ Leuven
NOT_YET_RECRUITING

Leuven, 3000, Belgium
Uniklinik Innsbruck
NOT_YET_RECRUITING

Innsbruck, 6020, Austria
Universitaetsklinikum Aachen AOeR
NOT_YET_RECRUITING

Aachen, 52074, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
NOT_YET_RECRUITING

Dresden, 1307, Germany
Universitaetsklinikum Erlangen
NOT_YET_RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Essen
NOT_YET_RECRUITING

Essen, 45133, Germany
Universitaetsklinikum Essen
NOT_YET_RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Hamburg-Eppendorf
NOT_YET_RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Heidelberg
NOT_YET_RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Leipzig AoeR
NOT_YET_RECRUITING

Leipzig, 4103, Germany
Universitaetsklinikum Regensburg
NOT_YET_RECRUITING

Regensburg, 93053, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
NOT_YET_RECRUITING

Mainz, 55131, Germany
University Health Network
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2C4, Canada
University Hospital Cologne
NOT_YET_RECRUITING

Cologne, 50937, Germany
University Hospital Zurich
NOT_YET_RECRUITING

Zurich, 8091, Switzerland
University Hospital Zurich - Children's Hospital Zurich
NOT_YET_RECRUITING

Zurich, 8008, Switzerland
University Hospital of Wales
NOT_YET_RECRUITING

Cardiff, CF14 4XW, United Kingdom
University hosptial of Antwerpen
NOT_YET_RECRUITING

Edegem, 2650, Belgium
University of Basel
NOT_YET_RECRUITING

Basel, 4031, Switzerland
University of Calgary - Alberta Children's Hospital
NOT_YET_RECRUITING

Calgary, Alberta, T3B 6A8, Canada

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