New drug shows promise in reversing liver scarring in major trial

NCT ID NCT06215716

Recruiting now Disease control Sponsor: Akero Therapeutics, Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 study tests a drug called efruxifermin in 1,650 people with non-cirrhotic NASH/MASH and moderate liver scarring (stage 2 or 3). Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug can reverse liver inflammation and scarring, and prevent serious liver events like liver failure or need for transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Efruxifermin (a drug given as a shot under the skin)

What this could lead to

If it works, this could provide a new treatment option for people with NASH/MASH and liver scarring, potentially reversing damage and preventing liver failure.

What could go wrong

This is a large Phase 3 trial, but the drug is still experimental. It may not work better than placebo, and side effects are possible. Results may not apply to everyone with the condition.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MASH WITH FIBROSIS NASH WITH FIBROSIS

Contacts and locations

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Study contacts

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Phone: •••-•••-•••• Email: •••••@•••••

Locations

Akero Clinical Study Site
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Birmingham, Alabama, 35209, United States

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Akero Clinical Study Site
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Dothan, Alabama, 36301, United States

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Chandler, Arizona, 85224, United States

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Flagstaff, Arizona, 86001, United States
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Peoria, Arizona, 85381, United States

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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85712, United States

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Tucson, Arizona, 85713, United States

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Tucson, Arizona, 85715, United States

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Akero Clinical Study Site
COMPLETED

Conway, Arkansas, 72032, United States
Akero Clinical Study Site
COMPLETED

Jonesboro, Arkansas, 72401, United States
Akero Clinical Study Site
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Little Rock, Arkansas, 72205, United States

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North Little Rock, Arkansas, 72117, United States

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Chula Vista, California, 91910, United States
Akero Clinical Study Site
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Coronado, California, 92118, United States

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Escondido, California, 92025, United States

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Folsom, California, 95630, United States

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Inglewood, California, 90301, United States

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COMPLETED

La Mesa, California, 91942, United States
Akero Clinical Study Site
COMPLETED

Lancaster, California, 93534, United States
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Lancaster, California, 93534, United States

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Long Beach, California, 90815, United States

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Los Angeles, California, 90036, United States
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Los Angeles, California, 90048, United States

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Los Angeles, California, 90057, United States

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Newport Beach, California, 92663, United States

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Orange, California, 92868, United States

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Palm Springs, California, 92262, United States

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Pasadena, California, 91105, United States

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Redwood City, California, 94063, United States

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Sacramento, California, 95817, United States

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San Diego, California, 92120, United States

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COMPLETED

San Diego, California, 92123, United States
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San Diego, California, 92161, United States

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San Francisco, California, 94115, United States

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San Francisco, California, 94117, United States

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Santa Maria, California, 93458, United States

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Aurora, Colorado, 80045, United States

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Colorado Springs, Colorado, 80907, United States

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Englewood, Colorado, 80113, United States

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New Haven, Connecticut, 06520, United States

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Washington D.C., District of Columbia, 20007, United States

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Washington D.C., District of Columbia, 20422, United States

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Bradenton, Florida, 34208, United States

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Brandon, Florida, 33511, United States

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Doral, Florida, 33126, United States

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Fort Myers, Florida, 33912, United States

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Gainesville, Florida, 32610, United States

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Hialeah Gardens, Florida, 33016, United States

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Inverness, Florida, 34452, United States

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Jacksonville, Florida, 32256, United States

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Lady Lake, Florida, 32159, United States
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Lakewood Rch, Florida, 34211, United States

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Largo, Florida, 33777, United States

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Lehigh Acres, Florida, 33936, United States

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Maitland, Florida, 32751, United States
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Margate, Florida, 33063, United States

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Miami, Florida, 33136, United States

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Miami, Florida, 33175, United States

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Miami Gardens, Florida, 33014, United States

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Miami Lakes, Florida, 33016, United States

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Naples, Florida, 34102, United States

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New Port Richey, Florida, 34653, United States
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Ocala, Florida, 34471, United States

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Orlando, Florida, 32807, United States

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Pembroke Pines, Florida, 33027, United States

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Port Orange, Florida, 32127, United States

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Riverview, Florida, 33578, United States

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Sarasota, Florida, 34240, United States

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Temple Terrace, Florida, 33617, United States

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COMPLETED

Venice, Florida, 34285, United States
Akero Clinical Study Site
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Viera, Florida, 32940, United States
Akero Clinical Study Site
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West Palm Beach, Florida, 33401, United States
Akero Clinical Study Site
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Weston, Florida, 33331, United States

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Winter Park, Florida, 32789, United States

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Winter Park, Florida, 32792, United States

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Zephyrhills, Florida, 33542, United States

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Atlanta, Georgia, 30309, United States

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Columbus, Georgia, 31904, United States

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Gainesville, Georgia, 30501, United States

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Marietta, Georgia, 30060, United States

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Chicago, Illinois, 60637, United States

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Hammond, Indiana, 46324, United States

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Indianapolis, Indiana, 46202, United States

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South Bend, Indiana, 46635, United States

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West Des Moines, Iowa, 50265, United States

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Topeka, Kansas, 66606, United States

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Wichita, Kansas, 67205, United States
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Louisville, Kentucky, 40202, United States

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Bastrop, Louisiana, 71220, United States

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Covington, Louisiana, 70433, United States

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Houma, Louisiana, 70363, United States

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Marrero, Louisiana, 70072, United States

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Metairie, Louisiana, 70006, United States

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New Orleans, Louisiana, 70112, United States

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New Orleans, Louisiana, 70121, United States

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Shreveport, Louisiana, 71105, United States

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West Monroe, Louisiana, 71291, United States

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Baltimore, Maryland, 21202, United States

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Glen Burnie, Maryland, 21061, United States
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Greenbelt, Maryland, 20770, United States
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New Bedford, Massachusetts, 02740, United States

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Novi, Michigan, 48377, United States

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Southfield, Michigan, 48075, United States
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Wyoming, Michigan, 49519, United States

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Ypsilanti, Michigan, 48197, United States
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Flowood, Mississippi, 39232, United States

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Columbia, Missouri, 65201, United States

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Kansas City, Missouri, 64131, United States

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St Louis, Missouri, 63123, United States

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Las Vegas, Nevada, 89106, United States

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Las Vegas, Nevada, 89109, United States

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Reno, Nevada, 89511, United States

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Florham Park, New Jersey, 07932, United States
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Jackson, New Jersey, 08527, United States

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Ridgewood, New Jersey, 07450, United States

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Somers Point, New Jersey, 08244, United States

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Sparta, New Jersey, 07871, United States

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Santa Fe, New Mexico, 87505, United States
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Buffalo, New York, 14203, United States

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Manhasset, New York, 11030, United States

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New York, New York, 10016, United States

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New York, New York, 10021, United States

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New York, New York, 10029, United States

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COMPLETED

New York, New York, 10033, United States
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Rochester, New York, 55905, United States

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Chapel Hill, North Carolina, 27514, United States

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Charlotte, North Carolina, 28204, United States

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Durham, North Carolina, 27710, United States

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Fayetteville, North Carolina, 28303, United States

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Morehead City, North Carolina, 28557, United States

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New Bern, North Carolina, 28562, United States

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Raleigh, North Carolina, 27612, United States

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Statesville, North Carolina, 28625, United States

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Columbus, Ohio, 43213, United States
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Dayton, Ohio, 45414, United States

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Springboro, Ohio, 45066, United States

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Westlake, Ohio, 44145, United States

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Hershey, Pennsylvania, 17033, United States

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Philadelphia, Pennsylvania, 19104, United States

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Philadelphia, Pennsylvania, 19107, United States

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Pittsburgh, Pennsylvania, 15213, United States

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Charleston, South Carolina, 29425, United States

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Columbia, South Carolina, 29204, United States
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Summerville, South Carolina, 29485, United States

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Chattanooga, Tennessee, 37421, United States

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Clarksville, Tennessee, 37040, United States

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Hermitage, Tennessee, 37076, United States

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Nashville, Tennessee, 37211, United States

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Amarillo, Texas, 79106, United States

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Austin, Texas, 78745, United States

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Austin, Texas, 78757, United States
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Austin, Texas, 78757, United States

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Bellaire, Texas, 77401, United States

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Brownsville, Texas, 78520, United States

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Corpus Christi, Texas, 78404, United States

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Dallas, Texas, 75203, United States

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Dallas, Texas, 75216, United States

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Dallas, Texas, 75230, United States

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Dallas, Texas, 75234, United States

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Dallas, Texas, 75390, United States

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Denison, Texas, 75020, United States

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Edinburg, Texas, 78539, United States

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Forney, Texas, 75126, United States

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Fort Worth, Texas, 76104, United States

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Houston, Texas, 77004, United States

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Houston, Texas, 77030, United States
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Houston, Texas, 77074, United States

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Houston, Texas, 77079, United States
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Houston, Texas, 77079, United States

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Houston, Texas, 77084, United States
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Lewisville, Texas, 75057, United States

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McAllen, Texas, 78504, United States
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McAllen, Texas, 78539, United States

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Pasadena, Texas, 77505, United States

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San Antonio, Texas, 78209, United States

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San Antonio, Texas, 78215, United States

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San Antonio, Texas, 78222, United States

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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78229, United States

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San Antonio, Texas, 78240, United States

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San Antonio, Texas, 782531, United States

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San Antonio, Texas, 78258, United States

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San Marcos, Texas, 78666-7502, United States

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San Marcos, Texas, 78666, United States

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Waco, Texas, 76710, United States

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Waco, Texas, 76712, United States

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Webster, Texas, 77598, United States

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Wichita Falls, Texas, 76301, United States

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Ogden, Utah, 84405, United States

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Salt Lake City, Utah, 84117, United States
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Sandy City, Utah, 84092, United States

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South Ogden, Utah, 84405, United States
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Falls Church, Virginia, 22042-3300, United States
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Newport News, Virginia, 23602, United States

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Norfolk, Virginia, 23502, United States

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Richmond, Virginia, 23226, United States

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Richmond, Virginia, 23235, United States

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Richmond, Virginia, 23249, United States

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Richmond, Virginia, 23298, United States

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Roanoke, Virginia, 24014, United States

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Suffolk, Virginia, 23435, United States
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Seattle, Washington, 98105, United States

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Spokane, Washington, 99218, United States

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Madison, Wisconsin, 53705, United States

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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina

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La Plata, Buenos Aires, B1902AWL, Argentina

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Ramos Mejía, Buenos Aires, B1704ETD, Argentina

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Buenos Aires, Distrito Federal, C1125ABE, Argentina

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Buenos Aires, C1118AAT, Argentina

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Buenos Aires, C1180AAX, Argentina

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Buenos Aires, C1280AEB, Argentina

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Broadmeadow, New South Wales, 2292, Australia

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Coffs Harbour, New South Wales, 2450, Australia

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Kogarah, New South Wales, 2217, Australia

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Liverpool, New South Wales, 1871, Australia

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Penrith, New South Wales, 2750, Australia

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Westmead, New South Wales, 2145, Australia

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Adelaide, South Australia, 5000, Australia

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Caulfield South, Victoria, 3162, Australia

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Epping, Victoria, 3076, Australia

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Frankston, Victoria, 3128, Australia

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Heidelberg, Victoria, 3084, Australia

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Melbourne, Victoria, 3004, Australia

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Murdoch, Western Australia, 6150, Australia

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Nedlands, Western Australia, 6009, Australia

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Perth, Western Australia, 6000, Australia

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Edmonton, Alberta, T6G 2X8, Canada

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Hamilton, Ontario, L8S 4K1, Canada

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Toronto, Ontario, M6H 3M1, Canada

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Vaughan, Ontario, L4L 4Y7, Canada

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Montreal, Quebec, H2X 3E4, Canada

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Terrebonne, Quebec, J7B6B7, Canada

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Nice, Alpes-Maritimes, 06202, France

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Lyon, Auvergne-Rhône-Alpes, 69008, France

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Strasbourg, Bas-Rhin, 67091, France

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Limoges, Haute-Vienne, 87042, France

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Clichy, Hauts-de-Seine, 92110, France

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Vandœuvre-lès-Nancy, Lorraine, 54511, France

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Angers, Maine-et-Loire, 49933, France

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Toulouse, Occitanie, 31059, France

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Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France

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Montpellier Cedex 5, Provence-Alpes-Côte d'Azur Region, 34295, France

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Créteil, Val-De-Marne, 94010, France

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Versailles, Yvelines, Île-de-France, 78000, France

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Paris, Île-de-France Region, 75013, France

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Würzburg, Bavaria, 97080, Germany

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Frankfurt am Main, Hesse, 60590, Germany
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Mainz, Rhineland-Palatinate, 55131, Germany

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Homburg, Saarland, 66421, Germany

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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04103, Germany

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Lübeck, Schleswig-Holstein, 23538, Germany

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Berlin, 10787, Germany

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Berlin, 13353, Germany

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Surat, Gujarat, 395002, India

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Surat, Gujarat, 395009, India

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Vadodara, Gujarat, 390007, India

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Mysore, Karnataka, 570001, India

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Thiruvananthapuram, Kerala, 695011, India

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Dahegaon, Maharashtra, 441108, India

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Mumbai, Maharashtra, 400012, India

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Nagpur, Maharashtra, 440010, India

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Pune, Maharashtra, 412201, India

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New Delhi, National Capital Territory of Delhi, 110017, India
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New Delhi, National Capital Territory of Delhi, 110029, India

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New Delhi, National Capital Territory of Delhi, 110060, India

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New Delhi, National Capital Territory of Delhi, 110070, India

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Chandigarh, Punjab, 160012, India

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Jaipur, Rajasthan, 302001, India
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Jaipur, Rajasthan, 302001, India

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Coimbatore, Tamil Nadu, 641005, India

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Hyderabad, Telangana, 500 004, India

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Varanasi, Uttar Pradesh, 221005, India
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Varanasi, Uttar Pradesh, 221005, India

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Kolkata, West Bengal, 700020, India
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Kolkata, West Bengal, 700020, India

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Kolkata, West Bengal, 700073, India

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Petah Tikva, Central District, 4941492, Israel

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Ramat Gan, Central District, 5265601, Israel

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Haifa, Haifa District, 3109601, Israel

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Haifa, Haifa District, 3436212, Israel

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Afula, Northern District, 1834111, Israel

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Nahariya, Northern District, 22100, Israel

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Nazareth, Northern District, 1610001, Israel

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Jerusalem, 9103102, Israel

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Jerusalem, 9112001, Israel

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Tel Aviv, 6423906, Israel

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San Giovanni Rotondo, Foggia, 71013, Italy

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Rozzano, Milan, 20089, Italy

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Torino, Turin, 10126, Italy

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Bologna, 40138, Italy

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Foggia, 71122, Italy

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Messina, 98124, Italy

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Milan, 20122, Italy
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Milan, 20122, Italy

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Modena, 41126, Italy

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Naples, 80131, Italy

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Novara, 28100, Italy

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Cuauhtémoc, Mexico City, 06700, Mexico

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Poznan, Greater Poland Voivodeship, 60-702, Poland

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Krakow, Lesser Poland Voivodeship, 31-501, Poland

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Wroclaw, Lower Silesian Voivodeship, 50-381, Poland

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Wroclaw, Lower Silesian Voivodeship, 53-673, Poland

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Warsaw, Masovian Voivodeship, 00-215, Poland

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Warsaw, Masovian Voivodeship, 02-672, Poland

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Gdansk, Pomeranian Voivodeship, 80-382, Poland

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Gdynia, Pomeranian Voivodeship, 81-537, Poland

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Częstochowa, Silesian Voivodeship, 42-202, Poland

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Katowice, Silesian Voivodeship, 40-040, Poland

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Katowice, Silesian Voivodeship, 40-081, Poland

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Lodz, Łódź Voivodeship, 90-127, Poland

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Manati, 00674, Puerto Rico

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Mayagüez, 00680, Puerto Rico

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San Juan, 00927, Puerto Rico

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Daegu, Daegu Gwang'yeogsi [Taegu-Kwangyokshi], 41944, South Korea

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Goyang-si, Gyeonggi-do, 1232, South Korea

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Incheon, Gyeonggi-do, 22332, South Korea

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Seongnam-si, Gyeonggi-do, 13620, South Korea
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Seongnam-si, Gyeonggido [Kyonggi-do], 13520, South Korea

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Daegu, Gyeongsangbugdo [Kyongsangbuk-do], 42601, South Korea

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Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03080, South Korea

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Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 04763, South Korea

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Sabadell, Barcelona, 08208, Spain

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Santander, Cantabria, 39008, Spain

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Majadahonda, Madrid, 28222, Spain

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Valencia, València, 46015, Spain

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Valencia, València, 46026, Spain

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Barcelona, 08035, Spain

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Madrid, 28007, Spain

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Madrid, 28027, Spain

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Seville, 41013, Spain

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Olten, Canton of Solothurn, 4600, Switzerland

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Bern, 3010, Switzerland

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Sankt Gallen, 9007, Switzerland

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Changhua, Changhua, 500, Taiwan

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Taichung, Taichung, 40447, Taiwan

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Tainan, Tainan, 73657, Taiwan

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Taipei City, Taipei, 10048, Taiwan

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Kaohsiung City, 833, Taiwan

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Tainan, 704, Taiwan

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Taoyuan, 333, Taiwan

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Yenimahalle, Ankara, 06500, Turkey (Türkiye)

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Bornova, İzmir, 35100, Turkey (Türkiye)

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Bursa, 16059, Turkey (Türkiye)

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Rize, 53020, Turkey (Türkiye)

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Birmingham, England, B15 2WB, United Kingdom

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Cambridge, England, CB2 0QQ, United Kingdom

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Liverpool, England, L9 7AL, United Kingdom

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London, England, E1 1BB, United Kingdom

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London, England, NW3 2QG, United Kingdom

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London, England, SE5 9RS, United Kingdom

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London, England, SW10 9NH, United Kingdom

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London, England, W2 1NY, United Kingdom
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Newcastle upon Tyne, England, NE7 7DN, United Kingdom

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