Osteoarthritis, knee

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This trial investigates whether adding hip strengthening exercises to a standard quadriceps program better preserves knee cartilage thickness and improves symptoms in people with knee osteoarthritis. Fifty-six adults with mild-to-moderate knee OA will be randomly assigned to one …

This trial compares two ways of aligning the knee during a bone-cutting surgery (high tibial osteotomy) for people with knee arthritis and bow legs. One method aims for natural knee motion (kinematic), the other for straight leg alignment (mechanical). The study will track 100 ad…

This study tests a stem cell product called XytriX, made from donated umbilical cord cells, for treating knee osteoarthritis. About 75 adults with mild to severe knee arthritis will receive an injection into the knee joint. The goal is to see if it safely reduces pain and improve…

This early-phase study tests a single injection of ICM-203, a gene therapy that delivers a gene to promote cartilage growth and reduce inflammation in the knee. About 18 adults with mild to moderate knee osteoarthritis will receive escalating doses to check safety and whether it …

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This early-phase trial tests whether a single injection of Mytocel MSK (made from a patient's own ear cartilage) can improve knee osteoarthritis better than standard PRP injections. Thirty adults with mild-to-moderate knee arthritis will receive either the new cell therapy or PRP…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This trial tests a new surgical system for knee osteoarthritis that uses 3D planning, custom guides, and augmented reality to improve alignment and reduce pain. About 150 people aged 40-70 with mild-to-moderate knee arthritis will be assigned to either the new system or tradition…

This study compares two surgical techniques to realign the knee in people with early arthritis and bowleg deformity. Twenty-eight adults will be randomly assigned to receive either a plate and screws or an external fixator to stabilize the bone after it is cut and repositioned. R…

This study compares robotic-assisted knee replacement to the traditional manual method in 170 adults aged 50-80 with end-stage knee arthritis. Participants are randomly assigned to one of the two surgeries and followed for 2 years to measure knee function, recovery speed, and cos…

This Phase 3 trial tests whether a single injection of MAG200 stem cells can improve pain and daily function in adults with knee osteoarthritis. About 573 participants will receive either a low dose, a high dose, or a placebo injection. The study aims to confirm if this approach …

This early-phase trial tests whether the weight-loss drug semaglutide can improve outcomes for obese patients waiting for total knee replacement. 54 participants will receive the drug for 48 weeks before and after surgery. The goal is to see if weight loss reduces pain and compli…

This study will test whether adding a T2 mapping sequence to a standard MRI can improve detection of early knee osteoarthritis. Researchers will compare MRI scans from 28 healthy volunteers and 28 patients with early OA. The goal is to see if this extra scan can measure cartilage…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study looks at whether a physiotherapist can accurately diagnose subacute knee injuries (lasting 1 week to 3 months) using a video consultation instead of an in-person exam. Researchers will compare three types of assessments: video-based, in-person without special knee test…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study looks at a personalized plan to help older adults prevent falls. It includes 50 people aged 65 or older who have sarcopenia (muscle loss) and knee or hip arthritis. Researchers will test balance, strength, and range of motion to create a tailored fall prevention strate…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether adding a simple numbing injection (SSSI) to standard pain blocks can better control pain after knee replacement surgery. About 90 adults aged 45-90 will be randomly assigned to receive either the extra injection or a sham (fake) one. The main goal is to s…

This trial compares three ways to manage pain after total knee replacement. All patients receive standard nerve blocks, but some also get an anti-inflammatory drug (dexamethasone) or a combination of dexamethasone and a sedative (dexmedetomidine). The goal is to see which approac…

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study investigates whether adding High-Intensity Laser Therapy (HILT) to standard physiotherapy helps people with mild-to-moderate knee osteoarthritis. Seventy-two participants will receive either real or sham laser sessions alongside exercise-based physiotherapy. Researcher…

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

This study will compare two treatments—low-level laser therapy and iontophoresis (a method that uses a mild electric current to deliver medication through the skin)—for knee osteoarthritis. Sixty-six adults aged 45 to 65 with mild to moderate knee arthritis will be randomly assig…

This study will follow 300 adults aged 50 and older with knee osteoarthritis who are scheduled for a 3-week thermal spa treatment. Researchers will use wearable sensors to measure knee movement fluidity before and after the spa program, and at 3 and 12 months later. They will als…

This study compares two ways to manage knee osteoarthritis: doing your own exercise at a local fitness center versus supervised sessions with a physiotherapist. Researchers want to see if the cheaper, more flexible gym option is just as good at reducing pain and improving quality…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether walking backwards on a treadmill (called retro walking) can help reduce pain and improve how people with knee osteoarthritis walk. Participants will do retro walking sessions, starting with 10 minutes and gradually increasing up to 30 minutes if pain stay…

This pilot study tests whether a topical CBD oil can reduce pain in people with knee osteoarthritis. Thirty participants will apply either CBD in castor oil or plain castor oil to their knees twice daily for 30 days, then switch treatments. Researchers will track pain scores and …

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study will test whether Egoscue postural exercises, alone or combined with a hands-on technique called Mobilization with Movement (MWM), can reduce pain, improve balance, and boost quality of life in people with knee osteoarthritis. Researchers plan to enroll 56 adults aged …

This study tests whether a gel called Conjuran can reduce pain in people with knee osteoarthritis better than the current standard treatment, Hyruan. About 180 adults with mild to moderate knee arthritis will receive two cycles of injections, each cycle consisting of five weekly …

This study tests whether a special exercise method called Sahrmann's approach can reduce pain and improve knee function better than standard physical therapy in people with knee osteoarthritis. Forty adults aged 40 to 60 with moderate knee arthritis will be assigned to one of two…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This study will test Mobithron Xtra, an oral supplement containing hyaluronic acid, collagen, and Boswellia extract, in 100 adults with knee osteoarthritis. Participants will take it once daily for 3 months while researchers track changes in pain, stiffness, and daily function us…

This study compares two pain relief methods after total knee replacement: a long-acting pain shot (Zynrelef) given directly into the knee during surgery versus a standard nerve block. The goal is to see which method better reduces the need for opioid painkillers in the first 72 h…

This study tests whether TECAR therapy—a device that delivers gentle heat deep into the knee—can reduce pain, improve balance, and boost quality of life in elderly men with knee osteoarthritis. Eighty men will receive either real TECAR plus standard physiotherapy or a sham versio…

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises at home, reducing pain and improving function as well as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving …

This study tests whether adding suzetrigine (Journavx) to standard pain management can lower pain and reduce the need for opioid painkillers after total knee replacement. About 75 adults with knee arthritis will take the drug as part of their post-surgery care. The goal is to imp…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study looks at whether using a gentle pulling force (mechanical traction) on the knee before or after exercise works better for easing pain and improving movement in people with knee osteoarthritis. Researchers will compare three groups: traction before exercise, traction af…

This study tests whether a special knee and heel brace, combined with strength exercises done while sitting or lying down, can reduce pain and improve walking in people with knee osteoarthritis. Twenty participants will be randomly assigned to get either this new brace or a stand…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study tests whether a special light treatment, called photobiomodulation, can reduce pain and swelling in people with long-term knee osteoarthritis. Researchers will measure pain levels before and after treatment in 30 adults aged 50 and older. The goal is to find a drug-fre…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This study compares two methods of pain control after total knee replacement: a single injection of numbing medicine versus a continuous drip through a small tube for 48 hours. About 78 adults aged 40-80 will be randomly assigned to one of the two groups. The goal is to see which…

This study tests two ways to numb the knee after total knee replacement. One method uses a low-dose anesthetic on three main nerves, while the other uses a higher dose on two smaller nerves. The goal is to see which provides better pain relief with less muscle weakness, so patien…

This study tests whether applying bee venom gel to the knee during ultrasound therapy can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40-75 will either get the bee venom treatment or a placebo gel. Researchers will measure pain, walking…

This study tests whether a substance made from stem cells (called secretome) can reduce pain and improve knee function in people with moderate knee osteoarthritis. Fifty adults aged 40-70 will receive either the secretome or a standard treatment (sodium hyaluronate) via injection…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study looks at whether a program called PREP helps veterans who need total knee replacement for osteoarthritis. The program includes exercises before surgery and a week of intense rehab after. Researchers will check pain, function, and mental health for up to a year after su…

This study tests a pain-relief method called cryoneurolysis, which uses cold to temporarily freeze nerves, for people waiting months for hip or knee replacement surgery. The goal is to reduce pain and the need for opioid painkillers, which can be risky if used long-term. Research…

This study tests whether adding high-intensity laser therapy to standard physical therapy helps reduce pain and improve movement after knee replacement surgery. About 46 adults aged 50 to 80 will be randomly assigned to receive either real laser therapy or a sham treatment alongs…

This study tests whether adding a new nerve block to standard pain treatment can reduce pain and improve recovery after total knee replacement. About 132 adults having knee surgery will be randomly assigned to receive either the standard block alone or the standard block plus the…

This study compares two types of physical therapy for knee osteoarthritis: one done in a pool and one on land. Sixty-six adults aged 40-65 with knee osteoarthritis will receive either aquatic or land-based mobilization therapy for four weeks. Researchers will measure pain, stiffn…

This study compares a new treatment—focused shockwave therapy—to standard physical rehabilitation for people with mild to moderate knee osteoarthritis. About 60 participants will be randomly assigned to one of the two groups. The goal is to see if shockwave therapy can reduce kne…

This study looks at whether adding trunk (core) stabilization exercises to standard physical therapy can reduce knee pain and improve daily function in people with knee osteoarthritis who also have back pain (knee-spine syndrome). About 70 adults aged 40-60 with moderate knee art…

This study looks at whether a special two-bar knee brace, combined with strength exercises that don't put weight on the knee, can help people with knee osteoarthritis feel less pain and stiffness. 18 adults aged 45-60 with moderate knee arthritis will be split into two groups: on…

This study will look back at medical records of 133 adults aged 40-70 with painful knee osteoarthritis who received a single injection of hyaluronic acid. The goal is to see if one shot can reduce pain, stiffness, and improve function, potentially offering a simpler alternative t…

This study tests a new drug called AD-211 to find the best dose for easing knee pain from osteoarthritis. About 200 people with knee osteoarthritis will take part in this double-blind, placebo-controlled trial. The main goal is to measure pain reduction during activity over 24 ho…

This study tests a robot-aided elliptical trainer designed to improve knee control in directions other than just bending and straightening. The goal is to reduce knee pain and improve function in 36 adults aged 45-85 with knee osteoarthritis. Participants will use the device to r…

This study tests whether a 3-week strength training program, done with or without a special knee brace, can improve muscle function and symptoms in people with moderate knee osteoarthritis. 120 participants aged 55-75 will be randomly assigned to different training and brace grou…

This study looks at whether walking to music or a metronome can help reduce pain and change how muscles work in people with chronic knee osteoarthritis. Twenty adults with knee pain will walk under different conditions—with music, with a metronome, or without either—while researc…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This study compares two minimally invasive procedures to relieve long-term knee pain from osteoarthritis. One uses radiofrequency (heat) to block pain nerves, the other uses a small amount of alcohol. About 50 adults aged 45-85 with moderate to severe knee pain will be randomly a…

This study compares two robot-assisted knee replacement methods for people with severe knee arthritis. One method uses a CT scan to plan the surgery (image-based), while the other uses a simpler approach without a scan (imageless). The goal is to see if the imageless method works…

This study tests a new injection called NANOVAE for people with knee osteoarthritis. The treatment is made from human amniotic fluid and is given directly into the knee joint. The goal is to see if it is safe and can help reduce pain and improve function. The study will include 2…

This phase 2 trial tests a wearable device that delivers continuous ultrasound to the knee for 1-4 hours daily, with or without a diclofenac pain patch, compared to a standard steroid injection. 240 adults aged 65-85 with mild to moderate knee osteoarthritis will use the device a…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This trial tests whether using ultrasound to guide a nerve-freezing procedure (radiofrequency ablation) is better than the standard X-ray-guided method for people with chronic knee osteoarthritis. Fifty-two adults over 50 with severe knee pain will be randomly assigned to one of …

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This study explores whether exercising just one leg can improve strength, balance, and pain in both legs for older adults with knee osteoarthritis. Forty-five participants aged 60-80 will be assigned to different unilateral training programs for 8 weeks. Researchers will measure …

This study tests a pre-surgery support program for people waiting for hip or knee replacement. The program includes education, medical navigation, and exercise to improve risk factors like blood sugar and fitness. Researchers want to see if the program is feasible and helps patie…

This study will compare the effects of a single injection of platelet-rich plasma (PRP) versus conditioned serum (CS) in 60 people with knee osteoarthritis. Participants must have had knee pain for at least 6 months and meet specific criteria. The goal is to see which treatment b…

This early-stage study tests a new anti-CD14 injection for knee osteoarthritis in 30 Veterans. The goal is to see if the shot is safe and feasible, and if it can reduce pain and improve function. Participants will receive either a low dose, high dose, or placebo injection and be …

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study compares two ways to restrict blood flow during exercise—using a special floss band or a traditional cuff—to see which better reduces pain and improves movement in people with knee osteoarthritis. 46 adults aged 40-60 with mild to moderate knee OA will do leg exercises…

This study tests whether a 5-minute guided breathing technique called box breathing can help older adults (65+) manage stress and recover better after total knee replacement. Thirty-two participants will be randomly assigned to either the breathing exercise or a control activity.…

This study tests whether tecar therapy, a type of targeted radiofrequency treatment, can reduce pain and improve physical function in people with chronic knee osteoarthritis. About 60 adults aged 40 to 75 with moderate knee arthritis will receive the therapy or a sham treatment. …

This pilot study tests whether pulsed electromagnetic field (PEMF) therapy can reduce pain and improve function in people with inflammatory knee osteoarthritis. Fifty participants will receive either active PEMF or a sham treatment twice a week for 8 weeks. The study measures pai…

This study tests whether a long-acting painkiller (bupivacaine-meloxicam) can reduce pain and the need for opioid medications after robot-assisted knee replacement. 150 adults with knee osteoarthritis will receive either the new painkiller or a standard injection. Researchers wil…

This study tests a special brace designed to gently distract (separate) the knee joint, aiming to reduce pain and improve function in people with medial knee osteoarthritis. Researchers will enroll 150 adults aged 30-70 with a BMI under 35. Participants will wear the brace and be…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This early study tests a device that uses gentle sound waves to treat chronic pain in the knee, nerves, or joints. Five adults with moderate-to-severe pain will receive a single 15-minute session. The goal is to see if the treatment safely reduces pain by at least half and improv…

This study tests two types of leg exercises—closed chain (like mini-squats) and open chain (like leg lifts)—both done with a blood flow restriction cuff on the thigh, in people with mild knee osteoarthritis. Forty participants aged 45-75 will do these exercises plus standard phys…

This study tests whether taking the drug tranexamic acid for up to 7 days after total knee replacement can improve pain, function, and knee movement. About 351 adults having knee surgery will be randomly assigned to take the drug for 3 days, 7 days, or a placebo. Researchers will…

This study tests whether doing balance exercises with your eyes closed soon after knee replacement surgery improves recovery. About 66 people aged 60-85 who had a knee replaced due to arthritis will be split into two groups: one does standard rehab, the other adds special balance…

This study tests whether adding dual-task exercises—combining physical movements with mental tasks—improves pain, balance, and function after total knee replacement better than standard home exercises alone. Forty adults aged 50-65 who had a knee replacement will be split into tw…

This study looks at whether cooling the knee after total knee replacement surgery can help reduce pain and improve early recovery. About 99 adults having knee replacement will be randomly assigned to receive cooling with a special bandage, an ice pack, or standard care without co…

This study tests whether using a heart rate sensor to personalize home exercise can reduce pain and improve daily function better than a standard exercise program. About 240 adults aged 45+ with mild-to-moderate knee osteoarthritis will follow a 12-week program, with follow-up at…

This study compares adding electrical dry needling to standard physical therapy versus physical therapy alone for knee osteoarthritis. Forty-four adults aged 40-60 with moderate to severe knee pain will receive treatment for 6 weeks. Researchers will measure changes in pain, knee…

This pilot study tests whether getting extra sleep (sleep banking) before knee or hip replacement surgery can help reduce chronic pain and the need for painkillers after the operation. Researchers will enroll 22 adults aged 18-74 scheduled for joint replacement at a Navy medical …

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This study tests whether a powder made from Rosa roxburghii (a type of rose fruit) can help people recover after total knee replacement surgery for osteoarthritis. 184 participants will take either the supplement or a placebo daily for 30 days after surgery. Researchers will meas…

This study tests whether applying metformin gel through the skin with a mild electric current (iontophoresis) plus physical therapy can reduce pain and improve function in postmenopausal women with knee osteoarthritis. Sixty-eight women aged 50-70 will receive either the active g…

This study compares two add-on treatments for knee osteoarthritis in overweight women: walking on an anti-gravity treadmill that unloads the joints, or taking alpha-lipoic acid and omega-3 supplements. Both aim to reduce pain and improve function better than standard physical the…

This study tests whether adding a procedure called fenestration (making small holes in the cyst wall) to standard aspiration and steroid injection can improve outcomes for people with painful Baker's cysts behind the knee. Forty-four adults with knee osteoarthritis and a Baker's …

This study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This pilot study tests whether a home-based brain stimulation device (tDCS) can help people recover better after total knee replacement. About 70 adults scheduled for knee surgery will use the device before and after their operation. The main goal is to see if the study is feasib…

This study looks at whether healthy lifestyle education and personalized physical activity advice can reduce pain and improve daily function in people with knee osteoarthritis. About 26 adults aged 40 and older with knee osteoarthritis will be placed into one of three groups: sup…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing the lower body) in 600 adults having knee or hip replacement as outpatient surgery. The goal is to see which method leads to successful same-day discharge without readmission. Researchers …

This study tests a nursing program based on the ABC-X model for 117 adults aged 30-65 getting their first total knee replacement. The program helps patients and families handle stress, find support, and think more positively. Researchers will measure mental strength, self-care, e…

This study tests whether adding a specific nerve-stretching exercise (femoral nerve mobilization) to standard physical therapy can reduce pain and improve function in people with knee osteoarthritis. Fifty patients aged 50 or older with mild to moderate knee arthritis will be ran…

This study will compare two different nerve block combinations used alongside standard anesthesia for total knee replacement surgery. One group gets an adductor canal block plus an iPACK block, while the other gets an adductor canal block plus a genicular nerve block. The goal is…

This study will enroll 68 adults aged 45-70 with grade III knee osteoarthritis to compare two physical therapy techniques: Mulligan mobilization with eccentric exercises versus Kaltenborn sustained mobilization with eccentric exercises. Participants will attend 3 sessions per wee…

This early-stage study tests a drug called CX-011 for moderate to severe knee osteoarthritis pain. About 72 adults aged 18-75 with knee osteoarthritis will receive the drug via injection into the knee joint. The main goals are to check safety and tolerability, and to see if it re…

This study tests whether a gel containing etodolac, applied to the skin over the knee, can improve pain and function when added to standard physiotherapy. Thirty people with mild to moderate knee osteoarthritis will receive either physiotherapy alone or physiotherapy plus the gel…

This study compares two physical therapy approaches for people with knee osteoarthritis: a gentle 'positional release' technique targeting tight leg muscles, versus balance and coordination exercises. Researchers will measure changes in pain, stiffness, and daily function in 60 p…

This study compares two surgical techniques for total knee replacement: mechanical alignment (the traditional method) and kinematic alignment (a newer approach). Researchers want to see which method leads to less pain and better knee function after surgery. About 96 adults with k…

This study compares two types of knee replacement surgery for people with arthritis on the inner side of the knee. About 100 adults will be randomly assigned to get either a partial or total knee replacement. Researchers will track pain, function, and quality of life for up to tw…

This study will compare sensory-motor training (exercises that improve how your brain senses joint position) with resistance training (strengthening exercises) in 52 adults aged 40-60 with early-stage knee osteoarthritis (Grade 1 or 2). The goal is to see which approach better re…

This study tests a gel called Sensovisc, injected into the knee joint to reduce pain and improve movement in people with knee osteoarthritis. About 75 adults with moderate knee arthritis will receive the gel and be followed for 6 months. The goal is to see if the gel safely eases…

This study will compare three common injection treatments for knee osteoarthritis: steroids, dextrose prolotherapy, and platelet-rich plasma (PRP). Seventy-two adults aged 40 to 80 with moderate to severe knee arthritis will receive one of the three injections. Researchers will m…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study tests a program called BOOST-OA designed to help veterans with knee osteoarthritis stick to their home exercise routines. The program includes goal-setting tools during physical therapy and follow-up health coaching calls for 9 months after therapy ends. Researchers wi…

This study tests whether a new tablet called Laybon is as good as an existing drug (Layla) at reducing knee pain from osteoarthritis. About 172 adults aged 40-80 with knee osteoarthritis will take either Laybon or Layla twice daily for 8 weeks. The main goal is to see if knee pai…

This study tests whether injecting tiny gold particles into the knee can reduce pain and the need for additional treatments in people with knee osteoarthritis. About 240 adults with long-term knee pain will receive either gold microparticles or a placebo. The goal is to see if th…

This study tests whether inulin, a prebiotic fiber from chicory root, can reduce inflammation and knee pain in older adults with osteoarthritis. Over 8 weeks, 84 participants will take either inulin or a placebo daily. Researchers will measure changes in blood markers of inflamma…

This study tests whether wrapping an elastic band around the knee (tissue flossing) combined with simple exercises can reduce pain and improve movement in people with knee osteoarthritis. Fifty-eight adults aged 40-70 with mild to moderate knee OA will be split into two groups: o…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This early-phase trial tests whether injecting a fluid made from stem cells (called secretome) mixed with growth factors from the patient's own blood can safely reduce knee pain and improve function in people with mild knee osteoarthritis. The study will enroll 25 adults aged 30-…

This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study will follow about 950 people who receive hip or knee replacements using Stryker implants, some with the Mako robotic-arm system and some without. Researchers will track how long the implants last and how well patients feel and function over five years. The goal is to g…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will test a new care pathway for rehabilitation after total knee replacement. The pathway includes a patient education booklet and optimized scheduling of physical therapy. Researchers want to see if this approach improves recovery and reduces differences based on race…

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study will compare women with knee osteoarthritis who also have lipedema (a fat tissue disorder) to those without lipedema. Researchers will use ultrasound to measure knee cartilage thickness and questionnaires to assess pain and daily function. The goal is to understand if …

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study will check how many people with knee osteoarthritis also have sarcopenia—a condition of low muscle mass and strength. Researchers in Upper Egypt will study 224 adults aged 40 and older to measure muscle health, nutrition, and quality of life. The goal is to better unde…

This study looks back at medical records of 3,500 adults who had a first-time knee replacement to compare different brands of knee implants. Researchers want to see which implant leads to better knee function, fewer complications, and lower costs over time. The goal is to help do…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether …

This observational study will measure two substances in the blood—COMP and MMP-3—in 60 people with knee osteoarthritis and healthy controls. Researchers want to see if these markers relate to pain, function, and X-ray findings. No treatment is given; the goal is to better underst…

This study looks at whether it's possible to run a larger trial of a community-based program called Good Boost+ for adults waiting for knee replacement surgery. The program includes weekly group water exercises and land-based exercises, plus peer support. Researchers will measure…

This study will follow 100 adults with knee arthritis who are scheduled for knee replacement surgery. Researchers will measure how changes in the shape of the knee bones after surgery affect how well the knee bends and how much pain patients feel. The goal is to find the best ali…

This study looks at whether using a tourniquet during total knee replacement is necessary. A tourniquet is a tight band that stops blood flow to reduce bleeding during surgery. Researchers want to see if doing the surgery without a tourniquet works just as well. Thirty adults wit…

This study will use special PET/MRI scans to look at changes in knee metabolism after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. The goal is to understand why some people get good pain relief and others do not. About 25 adults with moderate to…

This study tracks surgeon stress during partial knee replacements. Using a wearable vest, researchers measure heart rate, breathing, and energy burned while surgeons operate with either a manual or computer-assisted technique. The goal is to see if computer guidance makes the sur…

This study compares two different X-ray views—full-leg standing and Rosenberg—to measure a specific knee angle (MPTA) in 49 patients scheduled for high tibial osteotomy. The goal is to see if one view gives more consistent or accurate measurements, which could help surgeons bette…

This study will use advanced CT and MRI scans to see how knee realignment treatments (surgery or braces) affect bone structure and cartilage in 30 people with early knee osteoarthritis. Researchers want to understand why some treatments fail, so they can improve care for younger …

This study looks at how your sense of joint position, fear of moving, balance, and sensory processing affect recovery after knee osteoarthritis surgery. Researchers will measure these factors in 75 people aged 50-75 who had a total knee replacement 4-6 weeks ago. The goal is to b…

This pilot study will test whether a smartwatch can measure pain levels in 15 people with knee osteoarthritis. Participants will wear an Embrace Plus smartwatch that tracks electrodermal activity (skin signals) while reporting their pain during standard physical tests. The goal i…

This study aims to see if a submaximal bike test, called the Ekblom-Bak test, gives consistent results when repeated in people with hip or knee osteoarthritis. Forty patients will take the test twice, one to two weeks apart. The goal is to determine if this test can be reliably u…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will use a smart knee implant (Persona IQ®) to continuously track movement after total knee replacement surgery. Researchers want to compare two surgical approaches (medial parapatellar vs. subvastus) to see which leads to better early recovery. About 110 adults gettin…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study will compare MRI scans with standard X-rays to see which method better detects knee joint damage in adults with hemophilia who have had repeated bleeding in the knee. Researchers will use special scoring systems to measure early and advanced joint changes. The goal is …

This study looks at whether the bacteria in your gut (the gut microbiome) is different in people whose knee replacements fail versus those whose knees work well. Researchers will compare gut bacteria in 30 patients needing repeat knee surgery to those with successful implants. Th…

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…