Osteoarthritis, knee

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plu…

This trial compares two ways to deliver rehabilitation for women with knee osteoarthritis: in-person clinic visits versus tele-rehabilitation using a smartphone, tablet, or computer. Both groups receive hot packs and strengthening exercises. The study measures knee function, musc…

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study compared two types of total knee replacements in 160 patients with medial knee arthritis. One group received a fixed-bearing implant, the other a mobile-bearing implant. Researchers measured knee function and X-ray results to see if one design leads to better outcomes.

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study tested a plastic meniscus implant in 115 adults aged 30-75 who still had knee pain after having part of their meniscus removed. The goal was to see if the implant is safe and helps reduce pain and improve knee function. Participants were followed for up to 5 years afte…

This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safe…

This study tested whether a personalized surgical guide (TOKA) helps surgeons correct knee alignment more accurately than standard tools. 56 adults with medial knee osteoarthritis took part. The goal was to see if the custom approach leads to better bone alignment after surgery, …

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This study tested an experimental protein called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee osteoarthritis or cartilage injuries. 142 adults participated in two parts: one for cartilage lesions and one for osteoarthritis.…

This early-phase study tested whether a single injection of donor bone-marrow stem cells (StromaForte) is safe for people with mild-to-moderate knee osteoarthritis. Twelve adults received the injection and were monitored for side effects over 24 weeks. The main goal was safety, n…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This study tested a treatment called Chondron, which uses a person's own cartilage cells grown in a lab, against a standard surgery called microfracture for knee cartilage damage. 21 adults who had either treatment at least 2 years ago were compared. The goal was to see which app…

This Phase 2 trial tested whether an oral drug called RHH646 can help regrow cartilage in the knee for people with osteoarthritis. 82 adults aged 35 to 75 with knee osteoarthritis took either RHH646 or a placebo. The study measured changes in cartilage volume using MRI and tracke…

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This study looked at the safety and performance of the Journey II UNI partial knee replacement in 154 people with knee arthritis. The main goal was to see how many implants were still working well 5 years after surgery. Researchers also tracked any side effects and checked X-rays…

This study tested whether adding MegaCarti® to standard microfracture surgery improves knee cartilage repair in people aged 50-65 with knee cartilage injuries. 61 participants received either microfracture alone or microfracture plus MegaCarti®. The main goal was to see if MRI sc…

This study tested whether a visual biofeedback program during squats can improve knee loading and prevent osteoarthritis after ACL reconstruction. 34 participants were assigned to either standard physical therapy or standard therapy plus real-time visual feedback on a screen duri…

This study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.

This phase 2 trial tested an experimental drug called LRX712, given as injections into the knee, to see if it can help regrow cartilage in people with mild to moderate knee osteoarthritis. 45 participants received either the drug or a placebo over 8 weeks. The main goal was to me…

This early-phase trial tested a stem cell product called CARTISTEM in 12 adults with knee cartilage defects. The stem cells, derived from human umbilical cord blood, were implanted into the knee to see if they could safely help repair damaged cartilage. The study measured knee fu…

This study looked at how to best use antibiotics to prevent infections in people having knee replacement surgery. About 1,770 adults were split into groups that got antibiotics either just before surgery or for a full day after. The goal was to see if a single dose works as well …

This study tested a new drug called lorecivivint (SM04690) injected into the knee for people with moderate to severe knee osteoarthritis. 101 participants received two injections six months apart and were followed for a year. The goal was to see if the drug is safe and improves b…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This study compared two ways to perform partial knee replacement for osteoarthritis: using a robotic system (Navio) versus traditional manual tools. 66 adults with knee osteoarthritis took part. The goal was to see if robotic assistance leads to better leg alignment and implant p…

This study tested a new implant called Agili-C for people with knee cartilage damage or early arthritis. 251 participants received either the implant or standard surgery. The goal was to see if the implant improved pain and function over 5 years. Results suggest it may be a helpf…

This study looked at the long-term safety and potential benefits of using a patient's own fat-derived cells (stromal vascular fraction) to treat moderate knee osteoarthritis. Sixteen participants received a single injection into the knee and were followed for 10 years. The goal w…

This study tested whether combining a knee surgery (microfracture) with an injection of cells from the patient's own fat (SVF) works better than the injection alone for knee osteoarthritis. Fifty people with moderate knee arthritis took part. The researchers measured pain, knee f…

This study looked at whether giving tranexamic acid (a drug that helps blood clot) during knee replacement surgery reduces blood loss, and if a surgical drain is still needed. 192 patients with knee osteoarthritis were split into three groups: one got the drug plus a drain, one g…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tests a new radioactive tracer called [F-18]MHF to see if it can detect infections around knee implants using PET scans. Researchers will compare the tracer's uptake in infected versus non-infected implants in 18 adults. The goal is to improve diagnosis and reduce unne…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested whether taking tamsulosin, a drug used for bladder problems, before hip or knee replacement surgery could prevent urinary retention (inability to pee) afterward. 170 men took either tamsulosin or a placebo for five days before and two days after surgery. The mai…

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty participants will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for …

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The …

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study tested two acupuncture methods—thread-embedding and electroacupuncture—in 60 adults with knee osteoarthritis. Participants received 4 weeks of treatment plus standard care. The goal was to see which approach better reduced pain and improved knee function. Results may h…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study tested whether adding a special breathing therapy (intermittent hypoxia-hyperoxia) to standard physical therapy helps people with knee osteoarthritis. Sixty adults aged 45 and older with knee pain for at least 3 months took part. The breathing therapy involved short cy…

This study tested whether a higher concentration of ozone injected into the knee works better than a lower concentration for treating osteoarthritis. 159 patients received one of two ozone strengths and were followed for 3 months. Researchers measured pain, stiffness, and daily f…

This study tested a dietary supplement called INTOFINE-JOINT SUPPORT in 33 adults aged 40-60 with mild knee osteoarthritis. Participants took the supplement for 60 days, and researchers measured changes in pain, stiffness, and physical function using standard questionnaires and t…

This study compares two treatments for knee osteoarthritis: a nerve block injection guided by ultrasound and standard physical therapy. Researchers want to see which method better reduces pain, improves mobility, and helps balance. The study will include 66 adults aged 40-70 with…

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This pilot study tested whether village doctors in rural China can effectively deliver an exercise program for people with knee osteoarthritis. Sixteen participants either received supervised exercise three times a week for 12 weeks followed by independent exercise, or usual care…

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This study looked at 60 people having total knee replacement surgery to see which of two nerve blocks works better for pain control when added to a standard block. One block targets the space behind the knee (IPACK), the other targets a muscle plane (AMM). The goal was to reduce …

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This completed trial tested a new device called the NEUROCUPLE™ patch, which uses nanotechnology to reduce pain after knee replacement surgery. 156 adults were randomly assigned to receive either the active patch or a placebo patch for 30 days. The goal was to see if the patch co…

This study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…

This study tested whether a J-shaped skin incision, instead of the usual straight cut, can reduce numbness and pain after total knee replacement. Sixty-two patients with severe knee arthritis were randomly assigned to get either the standard or the J-shaped incision. The research…

This study looked at whether using a forced-air warming blanket during knee replacement surgery helps prevent hypothermia (low body temperature) and related problems like shivering. Researchers compared 240 patients who either got the warming blanket or standard care. The goal wa…

This study tested whether adding exercise plans created by AI chatbots (ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1) to standard physical therapy helps people with degenerative knee disease feel better and move easier. 84 adults aged 40-65 took part in an 8-week program with supe…

This study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …

This study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and o…

This study compared two minimally invasive procedures for knee osteoarthritis pain: genicular nerve radiofrequency ablation and intra-articular pulsed radiofrequency. Both use radiofrequency energy to reduce pain, but in different ways. Researchers enrolled 34 adults with knee os…

This study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves f…

This completed study tested two different physical therapy programs in 84 adults aged 40-60 with grade II knee osteoarthritis. One group received the Macquarie injury management protocol (soft tissue work plus exercises), while the other did a targeted knee exercise program. Rese…

This study tested whether injecting a steroid (betamethasone) directly into the torn meniscus of the knee provides better pain relief and function than the standard injection into the joint space. 70 people with stable degenerative meniscal tears were randomly assigned to one of …

This study tested two ways of applying radial pressure wave therapy to the knee in 82 people with knee osteoarthritis. The goal was to see if targeting specific joint lines works better than treating the most painful spots. Participants received three sessions and were followed f…

This study tested whether using virtual reality before or during total knee replacement surgery could help lower anxiety and improve recovery quality. 120 adults who had the surgery participated. The results showed that VR may be a simple, drug-free way to help patients feel calm…

This study tested whether holding a simple thigh muscle contraction for 5, 10, or 20 seconds best improves strength, pain, and daily function in people with knee osteoarthritis. 127 adults aged 40-65 with mild to moderate knee arthritis took part. All also received ultrasound and…

This study tested whether adding video-call support to standard physical therapy helps people recover better after total knee replacement. 44 adults aged 50-75 with knee arthritis took part. The goal was to see if tele-rehab reduces pain, improves movement, and helps people get b…

This study tested whether taking oral hyaluronic acid supplements along with hyaluronic acid injections works better than injections alone for knee osteoarthritis. 44 people aged 60-75 with knee arthritis took part. The goal was to see if the combination improves pain, stiffness,…

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This study tested whether applying a hot compress with black seed or ginger essential oil to the knees for 7 days could reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee OA were split into four groups: ginger oil plus heat, bla…

This pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to 10 weeks of exercise plus PNE or exercise alone. Researchers measured…

This study tested whether a home exercise program guided by the TRAK app could improve pain and function in people with knee osteoarthritis, compared to doing the same exercises without the app. Fifty patients over age 45 with knee pain took part. The goal was to see if telerehab…

This study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested a system that combines a wearable knee sensor with an exercise app to help people with knee osteoarthritis. The program provides personalized exercises and real-time feedback to ensure correct form. Thirty adults with knee osteoarthritis participated, and resear…

This study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvem…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadr…

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study tested a new robot device that helps people with knee osteoarthritis do rehab exercises at home after surgery. Ten adults used the device for one month to see if it improved their leg strength and knee function. The goal was to make recovery easier and faster, especial…

This study tested whether motivational interviewing, a counseling technique that helps people set and reach personal goals, could boost satisfaction in 149 patients undergoing knee replacement for osteoarthritis. Researchers measured how satisfied patients were with their rehabil…

This study tested a new treatment called CKD-981 to see if it can safely and temporarily ease knee pain in people with osteoarthritis. About 100 adults aged 40 to 80 with moderate knee pain took part. The treatment was compared to a fake procedure (sham) to measure its true effec…

This study tested whether a collagen injection into the knee could relieve pain and improve function better than a standard hyaluronic acid injection in 100 adults with knee osteoarthritis. Participants received one injection and were followed for up to 52 weeks. The goal was to …

This study looked at whether a numbing injection around knee nerves (genicular nerve block) can reduce pain and improve quality of life and joint position sense in people with chronic knee osteoarthritis. 40 adults aged 55-75 with moderate knee arthritis took part. The goal was t…

This study tested a step-by-step treatment plan for people with knee osteoarthritis pain. Participants first received duloxetine (Cymbalta), a drug that helps with pain, and then, if needed, an injection of hyaluronic acid mixed with a steroid into the knee joint. The goal was to…

This study tested whether giving the sedative drug dexmedetomidine during knee replacement surgery could lengthen the time before patients need additional painkillers. 94 adults having elective knee replacement under regional anesthesia received either the drug or a placebo. The …

This study tested whether adding a nerve block (adductor canal block) to standard local pain injections reduces pain after knee replacement surgery better than injections alone. 61 adults having knee replacement took part. The goal was to find a way to improve pain control and he…

This study looked at 60 people having knee replacement surgery to compare two types of nerve blocks for pain relief: the adductor canal block and the pericapsular nerve group block. The goal was to see which one provides better pain control and helps patients feel more comfortabl…

This study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) improves pain control after total knee replacement. 90 adults undergoing knee surgery received one of the two drugs or a placebo alongside the nerve block. Res…

This study looked at 130 people having knee replacement surgery for osteoarthritis. It compared two ways to manage pain: one using a nerve block near the knee, and the other adding extra numbing medicine around the joint. The goal was to see which method helped patients recover f…

This study tested an experimental drug called DFV890 in 115 adults aged 50-80 with painful knee osteoarthritis. Participants received either the drug or a placebo to see if it reduced pain and inflammation. The goal was to find a new way to ease symptoms and improve daily functio…

This study tested two treatments—shock wave therapy and pulsed electromagnetic field therapy—in 60 people with mild to moderate knee osteoarthritis. The goal was to see which one better reduces pain, improves daily function, and increases knee movement. Participants were aged 40 …

This study tested whether a health coaching program (called CAPPA) combined with a Fitbit could help employees with chronic knee pain become more physically active. Thirty-nine participants were split into two groups: one received physical activity coaching, the other received ge…

This study compared a single injection of sterile amniotic fluid to the standard steroid shot for knee osteoarthritis. 60 adults with moderate knee arthritis who had not gotten relief from other treatments took part. The main goal was to see if the amniotic fluid could reduce the…

This pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…

This study tested a pre-surgery exercise program using blood-flow restriction training in 16 older adults waiting for total knee replacement. The goal was to see if it is safe, well-tolerated, and improves muscle strength and function before surgery. Results will help design larg…

This study tested whether using a stationary bike with real-time feedback on pedaling force could improve deep sensation (like joint position and vibration sense) in 40 elderly patients with knee osteoarthritis. Participants also received standard treatments like TENS and ultraso…

This study tested whether a connected knee brace with a phone app could improve muscle strengthening rehab for people with knee osteoarthritis. 65 adults aged 50-80 used either standard rehab or the smart brace with remote physiotherapist supervision for 8 weeks. The goal was to …

This study tested whether adding a genicular nerve block to a standard femoral nerve block improves pain control after total knee replacement. Eighty adults having knee surgery were split into two groups: one got the standard block, the other got both blocks. Researchers measured…

This study tested two physical therapy methods for people with moderate knee osteoarthritis (grade II). One group received hands-on manual therapy (joint mobilization, massage), while the other got standard exercises and electrotherapy. Over 6-8 weeks, researchers measured pain, …

This study tested whether eccentric muscle training (lengthening exercises) improves walking performance in people with knee osteoarthritis compared to standard concentric training (shortening exercises). Forty adults aged 40-85 with knee osteoarthritis participated in 6 weeks of…

This study tested whether adding a specific massage technique (myofascial release) to standard physical therapy could improve quality of life for people with chronic knee pain. 45 adults with knee pain participated. The approach focused on a small muscle behind the knee called th…

This study tested whether injecting a mix of painkillers (bupivacaine, ketorolac, and epinephrine) around the knee during total knee replacement surgery could reduce pain and improve function better than standard pain medicines alone. Eighty adults with end-stage knee arthritis t…

This Phase 3 trial tested an experimental drug called RTX-GRT7039, given as an injection into the knee joint, to see if it reduces pain from osteoarthritis. 469 adults with knee osteoarthritis who did not get enough relief from standard treatments took part. The study compared th…

This Phase 3 trial tested whether a single injection of RTX-GRT7039 into the knee can reduce pain in adults with knee osteoarthritis who haven't gotten enough relief from standard treatments. 466 participants received either the drug or a placebo injection. The study measured pai…

This study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee …

This study looked at whether a special numbing injection (IPACK block) combined with a steroid shot can reduce pain in people with advanced knee osteoarthritis. 98 adults over age 40 with severe knee pain despite other treatments received the combination. Researchers measured pai…

This phase 3 trial tested the safety of an experimental drug called RTX-GRT7039, given as a knee injection to 714 adults with moderate to severe osteoarthritis pain that wasn't helped by standard treatments. The study focused on side effects and did not measure how well the drug …

This study tested two types of leg exercises in 24 women with knee osteoarthritis to see which better improves muscle strength, knee movement, and daily function. Participants did either eccentric (lengthening) or concentric (shortening) quadriceps exercises three times a week fo…

This pilot study tested whether adding a fibrin sealant (VeraSeal) to the standard medication tranexamic acid (TXA) during total knee replacement improves early recovery. 78 patients with end-stage knee osteoarthritis were randomly assigned to receive either TXA alone or TXA plus…

This study tested whether changing the angle of a leg exercise machine (N-K Table) from 0° to 50° helps people with knee osteoarthritis activate their thigh muscles more. Forty-three women aged 50-65 with knee osteoarthritis did isotonic knee extensions at both angles. Muscle act…

This early-phase trial tested a single injection of SYN321, a drug that breaks down into pain-relieving substances, in 35 people with painful knee osteoarthritis. The main goal was to check safety and tolerability at three different doses compared to a placebo injection. Research…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain control and getting patients moving sooner. One group got a fascia iliaca plane block, the other got a combination of adductor canal and IPACK blocks. Researche…

This study looked at whether adding platelet-rich plasma (PRP) injections to a supervised exercise program helps people with knee osteoarthritis more than exercise alone. 84 adults aged 40-70 with moderate knee arthritis took part. Researchers measured pain, function, and movemen…

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-co…

This study tested two simple home treatments for early-stage knee osteoarthritis: a structured exercise program versus a topical pain-relief gel (diclofenac). 83 adults aged 40-70 participated. The goal was to see which approach better reduces pain and improves daily function, he…

This study tested a new injectable lubricant called CCoat for people with mild to moderate knee osteoarthritis. 125 participants received either a single injection of CCoat or a placebo and were followed for six months. The goal was to see if CCoat safely reduces pain and improve…

This study tested two types of hyaluronic acid injections for knee osteoarthritis in 88 recreational athletes aged 50-70. One group received a single dose of cross-linked hyaluronic acid, while the other got two doses of straight-bonded hyaluronic acid. Researchers measured pain,…

This study tested whether using a cold and compression brace for six weeks after knee replacement surgery helps reduce pain and the need for painkillers. 208 patients who had a total or partial knee replacement were asked to use the brace five times a day for up to 20 minutes. Re…

This study tested two types of radiofrequency ablation—a procedure that uses heat to calm pain-signaling nerves—in 26 people with advanced knee osteoarthritis whose pain didn't improve with standard treatments. The goal was to see which method, conventional or cooled, better redu…

This study tested a 12-week exercise program designed for people with both congestive heart failure and knee osteoarthritis. 94 adults took part, with half doing low-impact aerobic and strength exercises and the other half receiving standard care. The goal was to see if the tailo…

This study looked at whether adding Tai Chi exercises to standard physical therapy helps older adults (ages 60-80) with knee osteoarthritis. 96 participants were split into three groups: standard therapy alone, therapy with virtual reality training, or therapy with Tai Chi. The g…

This study tested whether a self-administered oxytocin nasal spray could reduce pain and improve function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the spray or a placebo. The goal was to see if oxytocin, a natural pain-relieving hormone,…

This study tested whether a custom knee brace connected to a mobile app and motion sensors can improve symptoms and daily function for people with knee osteoarthritis. 36 adults aged 45-75 with mild to moderate knee OA wore their assigned brace for 6 months and completed surveys …

This study tested a new treatment for knee osteoarthritis using stem cells from umbilical cord tissue. 31 people aged 55-70 with moderate knee arthritis received the stem cells either with or without a minor knee surgery (arthroscopy). The goal was to see if the treatment could r…

This study compared two hands-on therapies—Strain Counter Strain and Myofascial Release—for people with knee osteoarthritis. 44 adults aged 40 to 65 with grade 2 knee osteoarthritis took part. The goal was to see which technique better reduces pain and improves daily function and…

This study looked at whether adding craniosacral therapy (a gentle, hands-on technique) to a home exercise program could reduce pain and improve function in people with knee osteoarthritis. Twenty-one adults participated, with one group receiving the therapy weekly for six weeks …

This study looked at 123 people who had knee replacement surgery using the MAKO robot. Researchers tracked their pain, steps, and motion with a Fitbit and knee brace to see if robotic help leads to faster recovery compared to traditional surgery. The goal is to find out if the ro…

This study tested whether a single injection of platelet-rich plasma (PRP) from the ACP Max™ system can help people with knee osteoarthritis. Forty-five adults with knee pain and X-ray evidence of arthritis received either the PRP injection or a standard steroid injection. The ma…

This pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain…

This study compared two physical therapy techniques—Mulligan's Pain Release Phenomenon and Kaltenborn Mobilization—for knee osteoarthritis. 44 adults aged 40-65 with early knee osteoarthritis received either technique plus conventional exercises for 6 weeks. Researchers measured …

This study tested a single injection of lorecivivint into the knee joint of 501 people with moderate-to-severe knee osteoarthritis. The goal was to see if it reduces pain and improves function over 56 weeks compared to a placebo. Participants reported their pain levels weekly, an…

This study tested two different therapy methods to help people with knee osteoarthritis feel less pain and move better. 44 adults aged 40 to 60 with moderate knee arthritis took part. One group received a special hands-on therapy called the Fascial Distortion Model, while the oth…

This study tested whether adding a nerve-freezing procedure (genicular nerve radiofrequency ablation) to standard knee replacement surgery could reduce pain and improve knee function afterward. Seventy adults with advanced knee osteoarthritis took part. The goal was to see if the…

This study tested whether L-carnitine, a natural supplement, can reduce pain, stiffness, and improve physical function in people with mild to moderate knee osteoarthritis. 66 participants took either L-carnitine or a placebo three times daily for 8 weeks. The goal was to see if L…

This study tested a single injection of a drug called lorecivivint in the knee joint of 496 people with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo (fake injection) over 28 weeks. Participants reported…

This study looked at 60 adults who had knee replacement surgery to see which of two nerve block combinations worked better for pain. One group got a biceps femoris short head block plus an adductor canal block, and the other got an IPACK block plus an adductor canal block. Resear…

This study looked at 45 people with knee osteoarthritis to see which combination of exercises works best for reducing pain and improving movement. Participants were split into three groups, each doing different mixes of strengthening, stretching, and biking exercises. The goal wa…

This study tested three simple distraction methods—virtual reality headset, a squishy squeeze toy, and poetry reading—to see if they could help control pain after total knee replacement surgery. 140 adults were split into four groups, with three trying one of the distractions and…

This early study tested whether injecting a special mixture of cells from a person's own belly fat into their arthritic knee is safe and doable. Nine adults with knee osteoarthritis received the injection. The main goal was to check for side effects, not to measure pain relief, s…

This study tested whether injecting a person's own processed fat (MFAT) into the knee works better than a standard steroid shot for osteoarthritis pain. Forty adults with moderate knee arthritis received either MFAT or a steroid injection. Researchers tracked pain and symptom cha…

This study looked at whether showing patients pictures of their damaged cartilage and new knee joint after surgery helps them feel better and move better early on. About 80 adults with severe knee arthritis who had a knee replacement took part. The goal was to see if seeing the p…

This study looked at two different massage methods—instrument-assisted soft tissue mobilization and cross fiber massage—to see which works better for pain and movement after total knee replacement. 50 adults aged 40-60 who had knee replacement surgery took part. The goal was to f…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested whether injecting a sugar-water solution (prolotherapy) into the knee, combined with a personalized exercise program, could reduce pain and improve function in people with knee osteoarthritis. 74 adults with grade 2 knee OA took part. Researchers measured pain, …

This study looked at 80 people who had knee replacement surgery for arthritis. It compared two methods of closing the skin: a special skin adhesive alone versus the same adhesive with a polyester mesh. The goal was to see which method gave better scar healing and made patients ha…

This study looked at two ways to manage pain after knee replacement surgery: a shot around the knee joint and a nerve block in the thigh. The goal was to see which method helps patients recover better and feel less pain. Sixty adults who had knee replacement took part, and their …

This study tested whether a special thermo-active knee sleeve (Reparel™) plus a standard corticosteroid injection works better than a plain compression sleeve plus the same injection for knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were followed…

This completed study looked at how Voltaren Gel (a topical pain reliever) affects mobility and quality of life in 196 adults with knee osteoarthritis pain. Participants used the gel as directed for up to 3 weeks while wearing an activity tracker. The goal was to see if the gel he…

This study tested whether using 10 mL or 20 mL of numbing medicine around the knee after replacement surgery could reduce the need for strong painkillers. 120 adults having knee replacement took part. The goal was to see if the smaller dose works just as well, with less medicatio…

This study tested a movement therapy called Mulligan mobilization in 36 people with knee osteoarthritis. The goal was to see if it could reduce pain and improve how muscles work. Participants were aged 50 to 70 with moderate knee pain. The therapy involves gentle, repeated moveme…

This study tested if using heat to destroy a nerve in the kneecap (patellar denervation) during total knee replacement surgery reduces pain and improves knee function afterward. 64 adults with knee osteoarthritis took part. The goal was to see if this extra step helps people reco…

This early-stage study tested a single injection of a new drug (SAR446959) into the knee joint of 32 adults aged 45-65 with knee osteoarthritis. The main goal was to check safety and how the drug moves in the body, not to prove it works. Participants were monitored for about 6 mo…

This study tested whether adding two specific hands-on therapies—muscle energy techniques and Mulligan mobilization—to standard physical therapy could improve hamstring flexibility and reduce daily limitations in people with knee osteoarthritis. Twenty-four adults aged 40 and old…

This study tested whether a learning instruction package could improve outcomes for people with knee osteoarthritis. 71 adults aged 20-60 with knee osteoarthritis took part. The package aimed to teach patients about their condition and how to manage it, with the goal of reducing …

This study looked at whether adding deep breathing or simple yoga poses to standard physical therapy could help people with knee osteoarthritis feel less afraid of moving. 40 adults aged 40-60 with severe knee pain took part. The results showed that both approaches helped reduce …

This study tested two types of nerve blocks to control pain after total knee replacement. 62 patients received either a new para-sartorial block or a standard femoral-sciatic block. The goal was to see which provides better pain relief with less muscle weakness. Results will help…

This study tested two different ultrasound techniques combined with standard physical therapy for knee osteoarthritis. 46 adults with knee pain and stiffness received one of the two ultrasound methods or physical therapy alone. Researchers measured pain, stiffness, and function b…

This study tested a drug called MT-5547 (fasinumab) in 626 Japanese adults with moderate to severe osteoarthritis pain in the knee or hip. Participants received either the drug or a placebo injection for 16 weeks. The goal was to see if the drug reduces pain and improves daily fu…

This study looked at whether a single-dose gel called CR500™ can ease knee osteoarthritis symptoms over a long period. Researchers followed up with 35 people who had already been in a previous trial of the gel. They measured pain and function using a standard knee score and asked…

This study tested whether a telerehabilitation program—where patients do exercises at home with remote support from a physiotherapist via video calls, phone, and texts—can reduce pain and improve knee function in people with knee osteoarthritis. 118 patients aged 50 and older wit…

This study looked at 27 women with knee osteoarthritis who received a single platelet-rich plasma (PRP) injection followed by a 6-week home exercise program. Researchers measured hip and knee strength and pain levels over 12 weeks. The goal was to see if this combination could re…

This study looked at 110 obese patients (BMI over 25) having knee or hip replacement surgery under spinal anesthesia. Researchers compared two ways to calculate the dose of the sedative remimazolam: using ideal body weight versus total body weight. The goal was to find which dose…

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, and researchers monitored them for 26 weeks. The goal was to …

This study tested a gel called Pandora, made of hyaluronic acid and tranexamic acid, injected into the knee to reduce pain and improve movement in people with knee osteoarthritis. 252 adults aged 35–85 with moderate knee arthritis received either one injection, three weekly injec…

This study tested different volumes of an ultrasound-guided nerve block (adductor canal block) to manage pain after total knee replacement. 90 adults scheduled for knee replacement under spinal anesthesia received one of two volumes. The goal was to see which volume reduces opioi…

This study tested whether ear acupoint therapy (a type of acupuncture on the ear) can help people recover faster after total knee replacement surgery. 116 patients aged 50-80 participated. The therapy aimed to reduce pain, swelling, anxiety, and improve knee movement and scar hea…

This study tested a portable device called the OrthoCor Advanced System in 23 people with knee osteoarthritis. The device delivers pulsed electromagnetic fields and heat to the knee, and users track their progress with a smartphone app. Researchers measured pain, range of motion,…

This study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …

This study tested a single injection of EVI-01, a hyaluronic acid gel, in 120 people with painful knee osteoarthritis. The goal was to find the best dose that reduces pain and improves function while being safe. Participants were randomly assigned to receive one of two doses of E…

This study tested Cognitive Muscular Therapy (CMT) for people with knee osteoarthritis waiting for joint replacement. CMT uses biofeedback to reduce muscle overactivity and improve posture, helping people change how they react to pain. The goal was to see if it could provide pain…

This study tested two different muscle energy techniques (a type of stretching) to see which one better improves hamstring flexibility in people with knee osteoarthritis. Fifty adults aged 40-60 with knee OA and tight hamstrings took part. The goal was to find a simple, non-drug …

This study tested a special nerve block called the parasartorial compartment block to see if it reduces pain after knee surgery. Sixty adults having knee surgery under spinal anesthesia received the block plus standard painkillers. Researchers measured pain scores and how much ex…

This study tested whether adding radial shock wave therapy to a standard exercise program helps people with knee osteoarthritis feel less pain and walk farther. 72 adults aged 50-85 with moderate to severe knee osteoarthritis took part. The treatment involved four sessions of sho…

This study tested whether adding high-power pain threshold ultrasound and vibration massage to standard treatment could help with calf muscle tightness in people with knee osteoarthritis. Sixty patients with moderate knee OA were split into three groups: standard care alone, stan…

This study tested whether injecting numbing medicine around the knee nerves can reduce pain and improve daily function in people with chronic knee osteoarthritis. 81 adults aged 45–75 received either a local anesthetic alone, a local anesthetic plus steroid, or a sham saline inje…

This study tested a new drug called CNTX-6970 in 55 adults aged 40-90 with moderate to severe knee osteoarthritis pain. The goal was to see if the drug safely reduces pain better than a placebo over 24 weeks. Participants used a mobile app to report their pain levels.

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study tested two different nerve block methods to control pain after total knee replacement surgery. Sixty older adults (ages 65-100) received either a two-level erector spinae block or an iPack with ACB block. The main goal was to see which method reduced the need for opioi…

This study tested whether combining a gentle brain stimulation technique (transcranial direct current stimulation) with mindfulness exercises could reduce pain after knee replacement surgery. Twenty-four adults who had knee replacement took part. The goal was to see if this appro…

This completed study tested whether taking melatonin (3 mg each night for 12 weeks) can safely reduce pain in people with knee osteoarthritis. Researchers enrolled 340 adults aged 40-80 with moderate knee pain. Half received melatonin and half received a placebo pill. The main go…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study tested a low-cost way to make platelet-rich plasma (PRP) from a patient's own blood for knee osteoarthritis. Twenty adults with mild to moderate knee OA received two injections of this homemade PRP. The main goal was to see if the PRP had enough platelets, similar to e…

This completed Phase 3 trial tested whether a weekly injection of semaglutide (2.4 mg) could help people with obesity and knee osteoarthritis lose weight and reduce knee pain. 407 participants received either semaglutide or a placebo, along with diet and exercise advice, over 68 …

This study tested whether the drug duloxetine, typically used for depression, can help reduce pain and the need for opioids after knee replacement surgery. Researchers enrolled 241 adults undergoing knee replacement and gave them either duloxetine or a placebo. The goal was to se…

This study tested a two-week home treatment combining gentle brain stimulation (tDCS) with mindfulness meditation in 208 older adults with knee osteoarthritis. The goal was to see if this drug-free approach could reduce pain and improve daily function. Results focused on changes …

This study tested whether Reiki, a hands-off energy therapy, or mindfulness meditation can reduce pain and stiffness in people with knee osteoarthritis. 164 adults were randomly assigned to receive Reiki, sham Reiki, mindfulness meditation, or no treatment for four weekly session…

This study tested whether a special non-compressive bioactive garment helps people recover better than standard TED stockings after total knee replacement. Twenty-three patients wore either the new garment or the standard hose, and researchers measured pain, swelling, range of mo…

This phase 2 trial tested an experimental implant called ATX101 that slowly releases the numbing drug bupivacaine into the knee after total knee replacement surgery. The study involved 226 adults and compared ATX101 to a saline placebo and standard bupivacaine injections. The goa…

This study tested whether showing people a photo of their new knee right after surgery helps them regain movement faster. 59 adults having knee replacement were randomly assigned to get a photo or not. Researchers measured knee bending at 6 weeks to see if the photo group did bet…

This study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …

This study tested whether a Fitbit activity tracker, a smartphone app, and phone calls with a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one participants were split into two groups: one received the program right away, the…

This study looked at whether adding the antidepressant duloxetine to a walking program helps older adults with both knee osteoarthritis and depression. All 43 participants received the same combination treatment. The goal was to see if the approach is feasible and if it reduces p…

This study compared robotic-assisted total knee replacement to the conventional technique in 95 patients with knee arthritis. The goal was to see if robotic surgery leads to better knee function, less pain, and higher satisfaction two years after the operation. Researchers also c…

This study tested an 8-week mindfulness program (MBSR) in 40 adults with painful hip or knee osteoarthritis. Participants learned to focus on the present moment to better manage chronic pain. The goal was to see if mindfulness could reduce pain and improve daily function compared…

This study tested a single injection of polyacrylamide hydrogel (Arthrosamid®) into the knee joint of 387 people with knee osteoarthritis. Researchers measured pain and physical function over 12 months. The goal was to see if the gel could reduce pain and improve everyday movemen…

This study tested two different knee injections for people with knee osteoarthritis. One injection was a common steroid (triamcinolone), and the other was a long-acting anti-inflammatory (tenoxicam). The goal was to see which one reduced pain and improved knee function better, wh…

This study tested whether a single injection of Hyruan-One works better than Synvisc or a saline placebo for knee osteoarthritis pain. 276 adults with knee osteoarthritis who had not gotten relief from other treatments took part. The main goal was to measure pain changes over 6 m…

This phase 2 trial tested whether a single injection of TTAX03, made from human amniotic and umbilical cord tissue, can reduce pain and improve function in people with advanced knee osteoarthritis (grades 3-4). 90 adults received either TTAX03 or a saline placebo, and researchers…

This study tested whether Baduanjin, a gentle mind-body exercise, can reduce pain, improve balance, and lessen fear of movement in people with knee osteoarthritis. Sixty adults aged 40 to 70 with moderate knee OA took part. They were split into three groups: one did standard exer…

This study tested whether a fiber supplement (inulin) and/or app-based exercises could reduce knee pain in 117 adults with osteoarthritis. Participants were split into groups: placebo, diet only, exercise only, or both. The main goal was to see if pain scores improved over time. …

This pilot study tested whether a weight loss program before total knee replacement helps improve recovery. 24 adults with obesity (BMI 35-40) were assigned to either a very low-calorie diet with health coaching or standard care. The goal was to see if the program was feasible an…

This study tested whether adding a gentle joint-gliding technique called Mulligan's mobilization to simple isometric exercises could help people with knee osteoarthritis. Fifty adults with moderate knee arthritis received either the mobilization plus exercises or a sham version f…

This study tested whether a 6-day course of oral methylprednisolone (a steroid) after total knee replacement can reduce pain, nausea, and the need for opioid painkillers. 101 adults with knee arthritis were randomly assigned to receive either the steroid taper or standard care. T…

This study followed 57 people with knee osteoarthritis for one year after they received an injection of NOLTREX™, a synthetic joint fluid. Researchers measured changes in pain, stiffness, and physical function using a standard questionnaire. The goal was to see if the injection p…

This study tested a special Tai Chi program that uses real-time biofeedback to help people with knee osteoarthritis reduce joint strain. Fifteen adults with knee pain participated, and researchers measured changes in knee joint load after four weeks. The goal was to see if this a…

This study tested whether adding morphine to a standard antibiotic injection into the shin bone during knee replacement surgery reduces pain afterward. About 100 adults having their first knee replacement took part. Half got morphine with the antibiotic, half got a placebo. Resea…

This completed trial tested whether adding medical treatments (lidocaine injections and shockwave therapy) to a knee education program could better reduce pain and improve function in people with knee osteoarthritis. 71 participants with moderate to severe knee pain were randomly…

This study tested whether remote, video-call supervised exercise works as well as in-person sessions for people with knee osteoarthritis. 48 participants did muscle-strengthening exercises for 12 weeks, either via video call or at a clinic. Researchers measured pain, function, an…

This study tested a medicated patch (HP-5000) containing diclofenac sodium against a placebo patch in 370 adults with osteoarthritis knee pain. For 12 weeks, participants wore the patch on their knee to see if it reduced pain and stiffness better than a dummy patch. The goal is t…

This completed study compared three common treatments for knee osteoarthritis (gonarthrosis) in 82 adults aged 40–65. Participants received either platelet-rich plasma (PRP) injections, topical diclofenac gel, or a structured exercise program for 6 weeks. The goal was to see whic…

This study tested whether a 2-week program of group education sessions and exercises before total knee replacement helps people recover function more quickly after surgery. 262 adults with knee osteoarthritis took part. The program included 4 education sessions and 4 exercise ses…

This study tested whether adding a topical gel (diclofenac) to a supervised exercise program helps knee osteoarthritis pain more than exercise or gel alone. 79 adults aged 40-65 with mild to moderate knee osteoarthritis took part. The results could help doctors recommend better n…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This completed study reviewed data from 31 patients who had knee replacement revision surgery due to aseptic loosening (the implant coming loose without infection). Researchers used a regional registry and X-ray analysis to understand the causes and economic impact. The goal was …

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, whic…

This study involved 20 adults over age 50 to measure how soft tissues (skin, fat, muscle) around the knee react when pressed by a brace. Researchers used an ultrasound probe to push on the leg and record force and displacement. The goal is to gather data that could lead to more c…

This study looked at 40 people who had knee replacement surgery to see if the type of implant affects recovery. One group got a cruciate-retaining implant, the other a posterior-stabilized implant. Researchers measured pain, function, fear of movement, quality of life, and how mu…

This pilot study looked at factors that predict pain and function after total knee replacement. Researchers tested a brief mindfulness-based cognitive behavioral therapy in a small group of patients and compared them to those receiving usual care. The goal was to see if this appr…

This study looked at different questionnaires that patients fill out after hip or knee surgery to see how well they measure recovery. Researchers wanted to find better ways to compare results across studies and understand what counts as a meaningful improvement for French patient…

This study looked at whether a team-based health assessment before knee or hip replacement surgery improves quality of life and reduces healthcare costs for patients aged 65 and older with multiple chronic conditions. 157 patients were randomly assigned to receive either usual ca…

This study looked at 50 adults having knee replacement surgery to see if a computer-guided tool (imageless navigation) can measure key knee angles as accurately as a CT scan. The tool creates a digital model of the knee during surgery, which could avoid the need for a preoperativ…

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how different positions affect joint space measurements in people with knee osteoarthritis. 21 patients had MRI scans while standing and lying down, with their knees bent and straight. The goal was to understand how these positions change the distance between…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at knee tissue that was removed during total knee replacement surgery in 29 patients. The goal was to learn more about how knee diseases and injuries affect bone and tissue structure, and to test new ideas for future treatments like custom implants or 3D-printed…

This study looked at how different types of shoe insoles affect knee movement and quality of life in people with knee osteoarthritis. Thirty participants were tested to see if insoles change how the knee works during walking and if any benefits are linked to these mechanical chan…

This study looked at how being tired affects the chance of tripping and falling in adults aged 55-70 with and without knee osteoarthritis. 24 participants wore activity monitors, walked on a treadmill for 30 minutes, and did strength and balance tests before and after. Researcher…

This study looked at 40 people with knee osteoarthritis who received injections of platelet-rich plasma (PRP) made from their own blood. Researchers measured pain, function, and inflammation markers to see how PRP might help. The goal was to better understand the treatment's effe…

This study looked at 64 people with knee osteoarthritis to see how balance and leg muscle strength relate to their ability to do everyday tasks like walking, standing up from a chair, and climbing stairs. Researchers used tests like the 6-minute walk and a balance platform to mea…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at 62 people with knee osteoarthritis to see which factors predict a good response to radial pressure wave therapy. Researchers analyzed data from a previous trial to find links between patient traits like age, weight, and pain levels and their improvement after…

This study looked at 20 people with severe knee arthritis who needed a knee replacement. They were randomly given one of two types of implants: a rotating platform or a fixed one. Researchers used 3D walking analysis before and after surgery to see which implant led to better wal…

This study examined whether arthritis in the hands is linked to more severe arthritis in the knees and hips. Researchers used hand X-rays to assess joint damage in 479 adults aged 40 to 75 with confirmed knee or hip arthritis. The goal was to better understand how arthritis progr…

This study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether patients need a blood transfusion. 102 patients were randomly assigned to get a drain or not. The goal is to see if drains help or hurt in terms of blood loss…

This pilot study tested whether wearable sensors (Syde devices) can reliably track knee osteoarthritis symptoms at home over two months. 43 participants wore the sensors on their ankles and wrists to record movement data, which was compared with standard clinic tests. The goal wa…

This study tested whether a mobile app (mymobility) paired with an Apple Watch can help people recover after hip or knee replacement surgery, possibly replacing standard physical therapy. Over 6,500 adults who were scheduled for joint replacement used the app for guided exercises…

This study looked at why the quadriceps (thigh) muscle sometimes stops working properly after total knee replacement surgery. Researchers measured muscle inhibition in 20 patients during their hospital stay and tracked their recovery for 6 weeks. The goal was to understand how th…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study tested a surgical navigation system called NextAR TKA that helps surgeons balance soft tissues during knee replacement. Forty adults scheduled for knee replacement with a specific implant were enrolled. The goal was to see if the system improves patient-reported outcom…

This study explored the connection between knee pain and the ability to sense the position of the lower back in 56 adults with knee osteoarthritis. Participants had their knee pain measured and performed a test to see how accurately they could feel their back's position. The goal…

This study examined nearly 100,000 people who had knee replacement for arthritis to see if those who previously had weight-loss surgery faced different risks of complications or needing another surgery. Researchers focused on how body weight at the time of knee replacement and th…

This study tested updated features of the ROSA Knee System, a robot used during knee replacement surgery. Forty adults having knee replacement took part. The goal was to check if the new features were safe and easy for surgeons to use, not to cure or treat the disease.

This study followed 285 adults who had knee replacement surgery for osteoarthritis. Researchers wanted to see how knee pain and the way people perceive their knee (like feeling it's less familiar or harder to control) are linked over time. Participants filled out questionnaires b…

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. The…

This study looked at two ways of doing a knee realignment surgery (open wedge high tibial osteotomy) to see which one keeps the important blood vessels behind the knee safer. 40 people with knee arthritis took part. Researchers used CT scans to measure the distance between the su…

This study tested a personalized web-based care plan for over 5,700 adults with knee or hip osteoarthritis. The goal was to help patients and their doctors make more informed decisions about treatments, including whether to have joint replacement surgery. The study measured how w…

This completed study looked at 84 adults with knee osteoarthritis to see how common fear of movement (kinesiophobia) is and how it relates to pain and daily function. Researchers measured fear, pain, and physical ability using standard questionnaires. The goal was to understand i…

This study tested whether a wearable sensor can detect changes in knee joint loading after a small amount of fluid is injected into the knee (simulating injury). Fourteen healthy adults aged 18-35 participated. Researchers measured walking patterns, muscle activity, and balance b…

This study looked back at 54 people who had a hip replacement with a specific part called the CL TRAUMA cemented stem. The goal was to see if the part was safe and worked well. Researchers measured how well patients could move and if they had pain using a standard hip score.

This study looked at 207 people who had knee replacement surgery to see if removing the surgical drain before or after the first physical therapy session makes a difference. The goal was to compare bleeding, complications, hospital stay, and pain. The results could help doctors d…

This study looked back at 200 patients who had a knee replacement using Simplex HV bone cement. The goal was to see if the cement kept the implant in place without needing a second surgery within two years. Researchers also measured knee motion and function using the Knee Society…

This completed study looked at 22 patients aged 65-90 who had total knee replacement surgery. Researchers wanted to understand why some patients experience a sudden drop in heart rate and blood pressure when the tourniquet (a tight cuff that stops blood flow) is released at the e…

This study followed 41 patients who received a scaffold implant for partial meniscal tears in the knee. Researchers collected data from telephone surveys and medical records to see how well patients were doing over time. The goal was to understand if this treatment helps with pai…

This study from the Mayo Clinic looked at 219 people getting total knee replacements to see if a blood test measuring an enzyme called tryptase could predict knee stiffness (arthrofibrosis) after surgery. Researchers measured tryptase levels before and after surgery and checked i…

This study followed 162 people who received a G7 hip cup system during hip replacement surgery. Researchers measured pain, function, and hip movement using standard scores. The goal was to see how the device performs in everyday patients with arthritis or other joint problems.

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contr…

This study looked at whether preserving or removing the infrapatellar fat pad (a small pad of fat in the knee) during total knee replacement leads to better outcomes for people with knee osteoarthritis. Over 370 participants were randomly assigned to one of two groups. Researcher…

This study looked at 20 older women with knee arthritis to see if having different strength in each leg affects their balance, walking, and daily activities. Researchers measured leg muscle strength and tested how well participants could stand up from a chair and walk. The goal w…

This study looked at two different ways surgeons align a new knee joint during replacement surgery. 52 adults with knee osteoarthritis were randomly assigned to one of two alignment techniques. The main goal was to track how much the implant moved over two years using special X-r…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …

This study looked at how much a new knee implant (GMK Sphere) moves inside the body over five years in 44 people with knee osteoarthritis. Researchers used a special X-ray technique to measure implant stability. The goal was to gather data to help design better knee replacements …

This study looked at how well a new type of uncemented knee implant stays in place over time in people with knee osteoarthritis. Researchers measured implant movement and bone quality in 31 patients who had knee replacement surgery. The goal was to check if the implant is safe an…

This study looked at 192 people aged 50-85 with knee arthritis who needed knee replacement surgery. Half had computer-navigated surgery and half had the traditional technique. The goal was to see if computer guidance helps the new knee last longer, improves function, or reduces c…

This study looked at whether two common steroid injections for knee osteoarthritis—betamethasone and triamcinolone hexacetonide—affect eye pressure differently. Eighty adults with early-stage knee pain received one of the injections, and their eye pressure was measured before and…

This study looked at how much patients with rheumatoid arthritis or knee osteoarthritis know about cardiovascular disease risks. Researchers surveyed 120 adults aged 40 and older using a 28-item knowledge scale. The goal was to compare awareness between the two groups and identif…

This study looked at two different methods of cleaning the bone during knee replacement surgery: a high-pressure water spray versus manual rinsing. The goal was to see which method helps bone cement stick better to the bone, which can affect how long the new knee lasts. One hundr…

This study looked at 60 people with knee osteoarthritis to see if testing muscle strength while doing a second task (dual task) gives different results than testing strength alone. Participants were between 40 and 65 years old and had moderate knee OA. The researchers measured le…

This study looked at whether hip precautions—like not bending too far or crossing legs—are needed after hip replacement surgery. Over 1,100 patients were randomly assigned to follow precautions or not for six weeks. Researchers tracked dislocations, return to daily activities, an…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This study looked at how video-guided acupuncture imagery treatment (VGAIT) changes brain activity in people with knee osteoarthritis. Researchers used brain scans to compare real acupuncture, sham acupuncture, and guided imagery in 125 adults aged 40-70. The goal was to understa…

This study looked at how pain in one knee affects the forces on the other knee during walking. Researchers measured walking patterns in 55 adults with knee osteoarthritis and healthy volunteers. The goal was to understand how the body adjusts movement to protect a painful joint, …

This study compared how well an AI chatbot (ChatGPT) answered common questions from people with knee or hip osteoarthritis versus answers from real doctors. 286 patients rated the responses for preference, length, and difficulty. The goal was to see if AI could provide acceptable…

This study looked at 250 adults having total knee replacement to compare two surgical approaches: resurfacing the kneecap (patella) with a plastic implant versus leaving the natural cartilage in place. The goal was to see which method leads to better knee function and comfort one…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study looked at why leg muscles shrink and get weaker right after total knee replacement surgery. Researchers studied 23 adults with knee osteoarthritis before and after their operation. They measured muscle fibers, energy-producing parts of cells, and physical activity to f…

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned about the biology of pain and how to manage it, while the other received standard information about joint damage. Researchers measured whether the type of education af…

This large observational study followed over 288,000 people with hip or knee osteoarthritis who received core treatment (education, exercise, and weight loss advice). The goal was to identify factors like socioeconomic status and other health conditions that predict long-term out…

This study looked at 20 people with knee arthritis who had a surgery called high tibial osteotomy (HTO) to realign their knee. The goal was to see how the surgery changed ankle pain and ankle joint alignment. Researchers measured pain and bone angles before and after surgery. The…

This study looked at whether placing a drain in the knee after total knee replacement reduces early postoperative pain. Sixty patients over age 60 were randomly assigned to receive a drain or not. Pain was measured before surgery and at discharge using a 0-10 scale. The goal is t…

This study looked at 33 patients who had total knee replacement surgery to see if their recovery scores at 6 hours were similar to those at 24 hours. The goal was to understand if patients could be safely discharged earlier. Researchers used a standard scoring system to measure r…

This study looked at whether using custom-made cutting guides, designed from a patient's CT scan, can help place a total knee replacement more accurately. The goal is to reduce the number of patients (up to 30%) who are unhappy with their new knee. Researchers reviewed 20 patient…

This study looked at two different designs of knee replacement implants in 60 people with arthritis. The goal was to see how much each implant moved inside the bone over two years using a special X-ray technique called RSA. The findings could help surgeons pick the better implant…

This study tested a noninvasive navigation system that measures how the knee moves before surgery. The goal is to see if this information can help surgeons choose or place knee implants more accurately. 40 adults with end-stage knee osteoarthritis who were scheduled for knee repl…