Knee surgery infection study: one antibiotic dose may be enough

NCT ID NCT03283878

Completed Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study looked at how to best use antibiotics to prevent infections in people having knee replacement surgery. About 1,770 adults were split into groups that got antibiotics either just before surgery or for a full day after. The goal was to see if a single dose works as well as longer treatment, which could reduce side effects and costs.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis susceptibility 6 osteoarthritis, knee periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIBIOTIC PROPHYLAXIS ARTHROPATHY OF KNEE

Contacts and locations

Locations

Augusta Health

Fishersville, Virginia, 22939, United States
BaylorScott&White Research Institute

Temple, Texas, 76508, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Duke University Medical Center

Durham, North Carolina, 27703, United States
Emory University

Atlanta, Georgia, 30322, United States
Mississippi Bone and Joint Clinic

Starkville, Mississippi, 39759, United States
NYU School of Medicine

New York, New York, 10003, United States
Ohio State University

Columbus, Ohio, 43210, United States
Rothman Institute

Philadelphia, Pennsylvania, 19107, United States
University Of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University Orthopaedic Associates, LLC

Somerset, New Jersey, 08873, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Maryland St. Joseph Medical Center & Orthopedic Associates

Towson, Maryland, 21204, United States
University of South Carolina

Columbia, South Carolina, 29208, United States

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