New patch could ease arthritic knee pain without a pill

NCT ID NCT04683627

Completed Symptom relief Sponsor: Noven Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a medicated patch (HP-5000) containing diclofenac sodium against a placebo patch in 370 adults with osteoarthritis knee pain. For 12 weeks, participants wore the patch on their knee to see if it reduced pain and stiffness better than a dummy patch. The goal is to provide a simple, topical option for managing osteoarthritis symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: diclofenac sodium topical patch
What this could lead to: If it works, this patch could offer a convenient, non-pill option to reduce knee pain and stiffness from osteoarthritis.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The patch may not work better than a placebo, and some people may have skin irritation or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OSTEOARTHRITIS PAIN OF THE KNEE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS PAIN OF THE KNEE

Contacts and locations

Locations

Applied Research Center of Arkansas

Little Rock, Arkansas, 72212, United States
Clinical Research of West Florida,Inc.

Clearwater, Florida, 33765, United States
Metroplex Clinical Research Center

Dallas, Texas, 75231, United States
Noven Pharmaceuticals, Inc.

Jersey City, New Jersey, 07310, United States
Palmetto Clinical Research

Summerville, South Carolina, 29485, United States
Partners in Clinical Research

Cumberland, Rhode Island, 02864, United States
Quality Research Inc.

San Antonio, Texas, 78209, United States
The Arthritis and Diabetes Clinic, Inc.

Monroe, Louisiana, 71203, United States
Universal Axon Clinical Research, LLC

Doral, Florida, 33166, United States
Velocity Clinical Research

Cincinnati, Ohio, 45242, United States