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Knee surgery tourniquet mystery: why some Patients' hearts slow down when the cuff is released

NCT ID NCT07002086

Knowledge-focused Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 22 patients aged 65-90 who had total knee replacement surgery. Researchers wanted to understand why some patients experience a sudden drop in heart rate and blood pressure when the tourniquet (a tight cuff that stops blood flow) is released at the end of surgery. They measured blood clotting factors and other markers before and after the tourniquet was opened. The goal was to learn how to prevent these dangerous changes in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors prevent dangerous drops in heart rate and blood pressure when the tourniquet is released during knee replacement surgery.
What could go wrong
This is a very small, completed observational study with only 22 patients. It does not test a new treatment, so it cannot directly lead to a cure or therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

22 people

The number who actually took part.

Started

Jun 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing knee replacement surgery

Ages

65 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA score: 1-3 * primary gonarthrosis Exclusion Criteria: * ASA score 4 and above * The diagnosis of secondary gonarthrosis * Concomitant rheumatological disorders * Concomitant peripheral vascular disease * Concomitant malignant disease * Presence of organ failure * Having active infection * Use of immunosuppressive drugs * Having addiction to cigarettes, alcohol or drugs * Use of anticoagulation medicine * Presence of metabolic disease * Presence of renal disease * Presence of familial hemophagocytic syndrome * Being unwilling to participate the study

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary gonarthrosis

Contacts and locations

Locations

  • Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

    Diyarbakır, 21070, Turkey (Türkiye)