Sugar-water shots and exercise may soothe knee arthritis pain
NCT ID NCT07355712
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether injecting a sugar-water solution (prolotherapy) into the knee, combined with a personalized exercise program, could reduce pain and improve function in people with knee osteoarthritis. 74 adults with grade 2 knee OA took part. Researchers measured pain, stiffness, and physical function using standard questionnaires, and also checked levels of certain inflammation-related proteins in the blood. The goal was to see if adding exercise to prolotherapy works better than prolotherapy alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hypertonic dextrose solution with lidocaine
- What this could lead to
- If it works, this could offer a non-surgical way to ease knee pain and improve mobility for people with osteoarthritis.
- What could go wrong
- This is a small, completed trial with 74 participants. The results may not apply to everyone, and the treatment involves injections that can cause temporary soreness.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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fkkmk UGM
Sleman, Special Region of Yogyakarta, 55281, Indonesia
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Other studies related to the condition(s) this trial covers.