Could a single injection repair arthritic knees?
NCT ID NCT03291470
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safety and effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TG-C (TissueGene-C), a single injection of cells that produce a growth factor to help repair knee cartilage
What this could lead to
If it works, this could provide a non-surgical treatment option that reduces pain and improves knee function for people with moderate knee osteoarthritis.
What could go wrong
This is a Phase 3 trial, but results are not yet published. The treatment may not work better than placebo, and there could be side effects from the injection or the cells.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bassil Aish
Huntington Beach, California, 92647, United States
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David Scott
Spokane, Washington, 99218, United States
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Duane Anderson
San Diego, California, 92120, United States
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Durga Tanneru
Dallas, Texas, 75230, United States
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Edward Tavel
Charleston, South Carolina, 29406, United States
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Haresh Boghara
Red Oak, Texas, 75154, United States
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Igor Grosman
Brooklyn, New York, 11235, United States
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Jan Hommen
Doral, Florida, 33126, United States
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Jeremy Hoff
Wilmington, North Carolina, 28412, United States
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Jonathan Samuels
New York, New York, 10016, United States
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Larkin Wadsworth
St Louis, Missouri, 63141, United States
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Leonel Reyes
San Antonio, Texas, 78215, United States
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Lisa Blair
San Antonio, Texas, 78229, United States
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Manjoo Sharma
Lewisville, Texas, 75057, United States
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Miguel Trevino
Clearwater, Florida, 33756, United States
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Minal Desai
Durham, North Carolina, 27704, United States
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Mira Baron
West Palm Beach, Florida, 33409, United States
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Nathan Rimmke
Rochester Hills, Michigan, 48307, United States
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Nebojsa Skrepnik
Tucson, Arizona, 85712, United States
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Peter Hanson
La Mesa, California, 91942, United States
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Priyesh Mehta
Dayton, Ohio, 45432, United States
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Richard Radnovich
Boise, Idaho, 83713, United States
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Robby Ann Quintos
Las Vegas, Nevada, 89109, United States
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Samy Metyas
Covina, California, 91722, United States
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Steve Sitar
Anaheim, California, 92801, United States
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Stuart Silverman
Beverly Hills, California, 90211, United States
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Thomas Schnitzer
Chicago, Illinois, 60611, United States