Knee surgery pain relief: could a simple injection replace opioids?

NCT ID NCT06112548

Completed Symptom relief Sponsor: Damascus University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting a mix of painkillers (bupivacaine, ketorolac, and epinephrine) around the knee during total knee replacement surgery could reduce pain and improve function better than standard pain medicines alone. Eighty adults with end-stage knee arthritis took part. The goal was to see if this approach lowers pain scores, reduces opioid use, and leads to fewer complications after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine, ketorolac, epinephrine, paracetamol
What this could lead to: If it works, this could offer a better way to manage pain after knee replacement, reducing the need for strong opioids and improving early recovery.
What could go wrong: This is a small, completed study with 80 people, so results may not apply to everyone. The injection adds drugs that can have side effects like allergic reactions or bleeding risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS (KNEE) ARTHROPLASTY COMPLICATIONS PAIN

Contacts and locations

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Locations

Damascus university

Damascus, Syria

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