New patch could replace opioids for knee surgery pain

NCT ID NCT06460350

Completed Symptom relief Sponsor: nCap Medical Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested a new device called the NEUROCUPLE™ patch, which uses nanotechnology to reduce pain after knee replacement surgery. 156 adults were randomly assigned to receive either the active patch or a placebo patch for 30 days. The goal was to see if the patch could lower pain and the need for opioid painkillers, offering a safer alternative.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NEUROCUPLE™ Patch (a non-invasive device using nanotechnology)
What this could lead to: If effective, this patch could provide a non-opioid way to manage pain after knee replacement, reducing opioid use and side effects.
What could go wrong: This is a single completed trial with 156 participants. Results may not apply to all patients, and the placebo-controlled design means the active patch may not prove superior.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

UPMC Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States

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