New shot aims to ease pain after knee replacement

NCT ID NCT06799845

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 28 times

Summary

This study tested a new drug called ATX101 in 226 adults having knee replacement surgery. The goal was to see if it reduces pain and the need for opioid painkillers compared to a placebo or the standard drug bupivacaine. The trial is now complete.

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Contacts and locations

Locations

  • Atlanta Centre for Medical Research

    Atlanta, Georgia, 30331, United States

  • Chesapeake Research Group, LLC

    Pasadena, Maryland, 21122, United States

  • Endeavor Clinical Trials, LLC

    San Antonio, Texas, 78240, United States

  • First Surgical Hospital

    Bellaire, Texas, 77401, United States

  • JBR Clinical Research, LLC

    Salt Lake City, Utah, 84107, United States

  • Legent Orthopedic Hospital

    Carrollton, Texas, 75006, United States

  • Memorial Hermann Village

    Houston, Texas, 77043, United States

  • NextStage Clinical Research

    Wichita, Kansas, 67214, United States

  • NextStage Clinical Research

    San Antonio, Texas, 78258, United States

  • Phoenix Clinical Research

    Tamarac, Florida, 33321, United States

  • Woodland International Research Group, LLC

    Little Rock, Arkansas, 72211, United States

Conditions

Explore the condition pages connected to this study.