New implant could ease pain after knee replacement, reduce opioid use
NCT ID NCT06799845
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested an experimental implant called ATX101 that slowly releases the numbing drug bupivacaine into the knee after total knee replacement surgery. The study involved 226 adults and compared ATX101 to a saline placebo and standard bupivacaine injections. The goal was to see if the implant provides better pain relief and reduces the need for opioid painkillers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ATX101 (bupivacaine implant)
What this could lead to
If it works, this could provide longer-lasting pain relief after knee replacement surgery and reduce the need for opioid painkillers.
What could go wrong
This is an early phase 2 trial with only 226 participants, so results may not apply to everyone. The implant may not work better than existing options, and there could be side effects like infection or implant-related issues.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Atlanta Centre for Medical Research
Atlanta, Georgia, 30331, United States
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Chesapeake Research Group, LLC
Pasadena, Maryland, 21122, United States
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Endeavor Clinical Trials, LLC
San Antonio, Texas, 78240, United States
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First Surgical Hospital
Bellaire, Texas, 77401, United States
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JBR Clinical Research, LLC
Salt Lake City, Utah, 84107, United States
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Legent Orthopedic Hospital
Carrollton, Texas, 75006, United States
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Memorial Hermann Village
Houston, Texas, 77043, United States
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NextStage Clinical Research
Wichita, Kansas, 67214, United States
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NextStage Clinical Research
San Antonio, Texas, 78258, United States
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Phoenix Clinical Research
Tamarac, Florida, 33321, United States
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Woodland International Research Group, LLC
Little Rock, Arkansas, 72211, United States