One-Shot knee gel may beat Two-Dose treatment for arthritis pain
NCT ID NCT07241442
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two types of hyaluronic acid injections for knee osteoarthritis in 88 recreational athletes aged 50-70. One group received a single dose of cross-linked hyaluronic acid, while the other got two doses of straight-bonded hyaluronic acid. Researchers measured pain, stiffness, and joint function over 6 months to see which worked better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyaluronic acid injection
What this could lead to
If cross-linked HA works better, it could mean fewer injections and longer pain relief for knee osteoarthritis patients.
What could go wrong
This is a small, completed study with 88 participants, so results may not apply to everyone. The benefit over standard treatment is uncertain.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Istanbul Medipol University
Istanbul, Turkey (Türkiye)