Knee pain relief without surgery? nerve block injections tested

NCT ID NCT07174167

Completed Symptom relief Sponsor: Haydarpasa Numune Training and Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether injecting numbing medicine around the knee nerves can reduce pain and improve daily function in people with chronic knee osteoarthritis. 81 adults aged 45–75 received either a local anesthetic alone, a local anesthetic plus steroid, or a sham saline injection. Researchers measured pain levels and walking ability over follow-up visits to see which approach worked best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: prilocaine and triamcinolone
What this could lead to: If effective, this nerve block could offer a non-surgical option to ease knee pain and improve mobility for people with osteoarthritis.
What could go wrong: This is a small, completed trial (81 people) with short-term follow-up. The effect may be modest or not last long, and results may not apply to everyone with knee OA.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENICULAR NERVE BLOCK GONARTHRITIS GONARTHROSIS; PRIMARY

Contacts and locations

Locations

Haydarpasa Numune Training and Research Hospital

Istanbul, Turkey (Türkiye)

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