Knee pain showdown: PRP, gel, or exercise – which works best?

NCT ID NCT05877027

Completed Symptom relief Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study compared three common treatments for knee osteoarthritis (gonarthrosis) in 82 adults aged 40–65. Participants received either platelet-rich plasma (PRP) injections, topical diclofenac gel, or a structured exercise program for 6 weeks. The goal was to see which approach best reduces pain, improves function, and boosts quality of life. Results may help guide treatment choices for this common condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich plasma (PRP), topical diclofenac, and exercise
What this could lead to: If this study shows one approach works better, it could help doctors choose the most effective treatment for knee osteoarthritis symptoms.
What could go wrong: This is a small, completed study with no phase designation, so results may not apply to everyone. PRP and exercise effects vary, and topical diclofenac may cause skin irritation.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GONARTHROSIS

Contacts and locations

Locations

Istanbul University-Cerrahpasa

Istanbul, Istanbul, 34500, Turkey (Türkiye)

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