Osteoarthritis, knee

This study tests whether injections of platelet-rich plasma (PRP) or stem cells from belly fat can help people with knee osteoarthritis. 160 adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to get PRP, stem cells, both, or a placebo. Researchers wi…

This study looks at how well a new knee replacement system, the JOURNEY™ II CR, works for people with knee osteoarthritis. About 170 adults aged 22 to 75 who need a total knee replacement will receive the implant. Researchers will measure knee movement, survival of the implant, a…

This study is testing a new modular shoulder replacement system in 105 people who need complex revision surgery due to joint disease, trauma, or cancer. The device can replace part or all of the upper arm bone. Researchers are tracking how long the implant lasts and how well pati…

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This study compares two versions of the Triathlon total knee prosthesis—one fixed with bone cement and one without—in 60 people with knee osteoarthritis. Researchers will use special X-ray techniques to see how well each implant stays in place over time, and also track patients' …

This study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…

This early-phase trial tests the safety of Allocetra-OTS, a cell therapy made from donor immune cells, injected into the knee joint of 18 people with end-stage osteoarthritis who are candidates for surgery. Researchers will monitor side effects and measure pain relief using a sta…

This study follows 16 people who previously received ICM-203 (a gene therapy) or a placebo for knee osteoarthritis. Researchers will track delayed side effects and measure changes in knee pain and function over time. The goal is to understand the long-term safety and effectivenes…

This study followed 413 people with hip arthritis who received a new type of hip replacement called the OXINIUM DH system. The goal was to see how well the implant worked and how safe it was over 10 years. Researchers checked pain, movement, and whether the implant stayed in plac…

This study is checking the long-term safety and performance of two hip implant devices (RingLoc Bipolar Acetabular Cup and Endo II Femoral Head) used in hip replacement surgery. Researchers will follow 116 patients who had their surgery at least eight years ago, tracking complica…

This study tests whether robot-assisted knee replacement surgery leads to better results than traditional manual surgery for people with knee osteoarthritis. About 95 participants will receive the robot-assisted procedure and use a special knee brace to track motion. Researchers …

This study follows 148 people with knee osteoarthritis who received the ANTHEM total knee replacement system. Researchers will check how well the implant holds up over 10 years by measuring survival rates and patient-reported knee function. The goal is to confirm the device is as…

This study looks at how safe and effective the ANTHEM CR total knee system is for people with non-inflammatory degenerative joint disease who need a total knee replacement. About 153 participants will be followed for up to 10 years to check implant survival, bone health, and any …

This study looks at two kinds of plastic used in total knee replacement surgery: one with vitamin E and one without. The goal is to see which one lasts longer, causes less wear, and helps patients move better. About 605 adults with knee arthritis or similar problems took part, an…

This pilot trial aimed to test the safety and feasibility of a single injection of a patient's own fat-derived cells (stromal vascular fraction) into the knee for post-traumatic osteoarthritis. It was designed for adults aged 18–45 with a history of knee injury. However, the stud…

This study looks at how well a specific knee replacement device, the Triathlon All-Polyethylene Tibia, works in people with knee arthritis. Researchers will follow 204 patients who already have the device to see how their knee function and pain change over time. The goal is to ch…

This study tests whether a protein called TPX-100, injected into the knee, can safely reduce pain and improve function in people with mild to severe knee osteoarthritis. About 270 adults aged 50 to 80 will receive either the drug or a placebo once a week for four weeks, then be f…

This study tests whether stem cells taken from a person's own belly fat can help regenerate knee cartilage and reduce pain from osteoarthritis. Sixty adults with moderate to severe knee arthritis will receive either a stem cell injection or a standard hyaluronic acid shot. Resear…

This study follows 100 people who received a new type of knee replacement device called EVOLUTION® NitrX™. The goal is to see how safe and effective it is over time. Participants have conditions like arthritis or knee damage. The main measure is a patient-reported score of knee f…

This pilot study looks at combining two knee surgeries into one: a partial knee replacement and an ACL repair. It aims to see if doing both at the same time is safe and effective for people with knee arthritis and a torn ACL. The study will collect data from 15 patients to measur…

This study compares two types of knee replacement surgery for people with arthritis limited to the kneecap area. One hundred patients will be randomly assigned to receive either a partial replacement (patellofemoral arthroplasty) or a full knee replacement. The goal is to see whi…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This Phase 3 trial tests a single injection of TG-C, a cell-based treatment, in 535 people with moderate knee osteoarthritis. The goal is to see if it reduces pain and improves knee function compared to a placebo injection. Participants are followed for two years to check safety …

This study follows 700 people receiving a Persona total knee replacement to see how well the artificial joint works over time. Researchers will measure pain, function, and quality of life using patient questionnaires, and track how long the implant lasts (up to 10 years). The goa…

This study follows 163 people who received a LEGION knee replacement with a special VERILAST bearing surface to treat degenerative joint disease. Researchers track how long the implant lasts and how well patients function over time. The goal is to see if this newer device perform…

This study looks at how stable a new type of knee replacement part (the tibial baseplate) is over time. It involves 31 people with knee osteoarthritis who are getting a total knee replacement. Researchers will use special X-rays to measure any movement of the implant between 6 mo…

This study follows 30 people with knee osteoarthritis who receive a cementless total knee replacement. Researchers use special X-ray techniques to measure how much the implant moves over two years. The goal is to see if the implant stays firmly in place, which could mean better o…

This Phase 3 trial tests whether a single injection of ELIXCYTE, made from donor stem cells, can reduce knee pain better than a placebo (saline). About 165 adults aged 40-80 with moderate knee osteoarthritis who haven't gotten relief from standard treatments are participating. Th…

This study aimed to see if using a robotic system for partial knee replacement leads to better outcomes than traditional surgery. It planned to follow patients for 10 years to measure how much they 'forgot' about their new knee and how long the implant lasted. However, the study …

This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over …

This early-stage trial tests whether injecting a patient's own stem cells into the knee can safely treat osteoarthritis and cartilage defects. Sixteen adults with knee pain will receive one injection of stem cells grown from their own bone marrow. Researchers will track side effe…

This study follows 200 people who receive a cementless knee replacement (GMK Sphere) to see how long the implant lasts and how well it works. Participants have severe knee damage from arthritis or other conditions. The goal is to monitor safety and performance in real-world use, …

This study compares two types of knee implants for people with knee osteoarthritis: one fixed with bone cement and one without. 70 participants will be randomly assigned to receive either a cemented or cementless implant. The goal is to see which type stays better fixed in the bo…

This study looks at how well a partial knee replacement device called MOTO Medial® works for people with knee osteoarthritis. About 269 adults will be followed for several years to see if their pain, knee function, and quality of life improve after surgery. The goal is to help pe…

This early-phase trial is testing a new biological treatment called ANT-301 in 6 people with severe knee osteoarthritis. The main goal is to check safety, but researchers will also measure pain and knee function. If safe, larger studies could follow to see if it truly helps.

This study compares two types of knee implants (NexGen CR and Persona CR) in 160 people with knee osteoarthritis. Researchers will measure how well the implants stay in place, how satisfied patients are, and how active they become after surgery. The goal is to find out which impl…

This study tests a new uncemented knee replacement made with a porous metal called Tritanium, which may help bone grow into the implant for stronger fixation. It compares this to the standard cemented knee replacement in 72 patients with osteoarthritis. The goal is to see if the …

This study compares two robotic-assisted systems (Velys J&J and Cori S&N) for total knee replacement in 200 people with severe knee arthritis. Researchers will measure knee alignment, movement, and patient-reported outcomes like pain and function. The goal is to see if one robot …

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study tests a wearable device called TracPatch that sticks to the shin after total knee replacement surgery. The patch tracks knee motion, temperature, and steps for six weeks, sending data to doctors. Researchers want to see if this real-time monitoring helps patients regai…

This study tests whether a supervised exercise program before hip or knee replacement surgery can improve recovery, function, and quality of life. 44 adults with advanced osteoarthritis will do 3 weekly physiotherapy sessions plus daily home exercises for several weeks before the…

This Phase 2 trial tests whether a paste made with ejiao (a traditional Chinese ingredient) can reduce knee pain in people with osteoarthritis. Sixty adults with knee pain will use either the ejiao paste, a similar paste without ejiao, or a synthetic control. The study aims to se…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study tests whether a dietary supplement called Native CT-II® (a type of collagen from chicken sternum) can reduce pain and improve knee function in people with knee osteoarthritis. About 114 adults aged 40-65 with moderate-to-severe knee pain will take either the supplement…

This pilot study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. The treatment blocks abnormal blood vessels in the knee to reduce pain and swelling. Twenty participants will be randomly assigned to either receive the …

This study tested whether a personalized exercise program done 2-4 weeks before knee or hip replacement surgery could improve thinking and reduce delirium in adults aged 55 and older. Participants wore activity trackers and used a smartphone app. The study was suspended, so resul…

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study tests whether injecting tiny beads into arteries around the knee can reduce pain in people with moderate to severe knee osteoarthritis. The beads block blood flow to the painful area. Nine adults aged 40 to 80 who have not gotten relief from standard treatments are tak…

This study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to…

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patient…

This study compares two methods of giving the pain medicine EXPAREL during knee replacement surgery. About 40 adults will receive the medicine either as a targeted block or as local infiltration. Participants will report their pain levels and any extra pain medicines they need. T…

This study compares a single large injection of hyaluronic acid to three smaller weekly injections for knee osteoarthritis. Researchers want to see if the one-shot approach is as safe and effective at reducing pain and improving knee function. The trial involves 46 adults aged 40…

This study tests a new treatment called BRC-OA, made from donated human fat tissue, for people with mild to severe knee osteoarthritis. The goal is to see if it safely reduces pain and improves knee function. About 42 adults aged 18-80 will receive one of two doses or a control, …

This study looks at whether starting to walk earlier after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain and improve function in people with knee osteoarthritis. About 72 participants will either start partial weight bearing at 2 weeks or wait until …

This study looks at 600 hip or knee replacement patients to compare three different wound closure products: Sylke adhesive dressing, Exofin skin glue, and Suture Strip Plus. The goal is to see which method causes the fewest allergic skin reactions and gives the best scar appearan…

This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to bette…

This study tests whether doing guided exercises at home via video calls can reduce pain and improve movement in people with hip or knee osteoarthritis. 110 participants will either receive remote exercise sessions or standard education about their condition. The goal is to see if…

This study compares two types of blood flow restriction therapy (using a cuff to limit blood flow during exercise) against standard moderate strength training in 75 people with knee osteoarthritis. Participants will do supervised exercises twice a week for 8 weeks. The goal is to…

This study looks at whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the knee can reduce pain and improve movement in people with knee osteoarthritis. The trial involves 110 adults over 35 with knee arthritis. Researchers are…

This study was designed to see if an artificial intelligence app could help people with knee osteoarthritis do their exercises correctly at home. It planned to compare the app group to a group using a paper exercise booklet. The study was withdrawn before any participants were en…

This study tests whether a new drug called suzetrigine can control pain after knee replacement surgery as well as oxycodone, a common opioid. About 140 adults with knee osteoarthritis will receive either suzetrigine or oxycodone for two weeks after surgery. Researchers will track…

This study looks at whether a 12-week group exercise program called Les Mills Thrive can change how muscles work and improve strength, balance, and symptoms in 42 older adults with knee osteoarthritis. Participants will attend weekly classes that include flexibility, strength, an…

This study looks at whether adding cognitive behavioral therapy (CBT) and exercise to knee replacement surgery helps reduce pain and improve function. About 282 adults with knee osteoarthritis are randomly assigned to one of three groups: a non-surgical program with CBT and exerc…

This study tests whether a combination of a structured exercise program and a plant-based anti-inflammatory diet (the New Nordic Diet) can improve quality of life for people with mild to moderate knee osteoarthritis. Sixty participants will follow the training and diet plan, and …

This study tests a new medicine called Allocetra for people with knee osteoarthritis. It is injected directly into the knee joint to see if it safely reduces pain and improves function. About 160 adults aged 45-80 with moderate knee arthritis will receive either Allocetra or a pl…

This study tests whether adding ultrasound-guided nerve blocks before hip or knee replacement surgery can reduce pain and opioid use compared to standard pain management. 400 adults with osteoarthritis will be enrolled. The goal is to improve recovery and reduce side effects like…

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It involves injecting microscopic spheres into a knee artery to reduce blood flow and inflammation. About 100 people with moderate to severe knee pain will be randomly assigned t…

This study looks at whether a smaller dose of steroid injected into the knee with ultrasound guidance works as well as a larger dose given without ultrasound. The goal is to reduce side effects while still easing pain. About 140 people with knee osteoarthritis will receive one of…

This study looks at whether adding mental imagery or watching exercise videos to standard physical therapy can help people who have had a knee replacement. About 36 adults will be split into three groups: standard therapy alone, standard therapy plus guided imagery, or standard t…

This study tests whether a short course of oral methylprednisolone (a steroid) after knee replacement surgery can lower pain, reduce the need for strong painkillers, and lessen nausea. About 116 adults with knee osteoarthritis are taking part. The goal is to see if this simple me…

This study tests whether a nerve block combined with a thigh tourniquet can reduce pain in the back of the knee after total knee replacement. About 60 adults aged 40-85 will participate. The goal is to improve comfort and reduce the need for strong painkillers.

This study compares a standard physical therapy program with a targeted exercise program designed to improve knee alignment in adults aged 30-55 with mild to moderate knee osteoarthritis and bow-legged alignment. About 80 participants will do either standard exercises or specific…

This study was designed to test whether a new gel called Hydrogel OA 2% could safely relieve knee osteoarthritis pain better than a standard treatment. It planned to enroll adults with knee OA and give them one injection, then track side effects and symptom improvement for 26 wee…

This study compares two types of pain-relief pumps placed inside the knee joint after total knee replacement. 65 adults having outpatient knee surgery will be randomly assigned to receive either standard pain management or one of two pump brands. The goal is to see which approach…

This study tests whether a numbing and anti-inflammatory injection around the knee nerves can reduce pain and improve walking in people with knee arthritis. Thirty adults aged 50 and older with persistent knee pain will receive either the active injection or a placebo (salt water…

This study tests whether a powered knee exoskeleton called Keeogo can help veterans with knee osteoarthritis walk, climb stairs, and perform daily tasks with less pain compared to standard knee braces. Thirty-two veterans with moderate to severe knee osteoarthritis will try both …

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower…

This study tests whether blocking certain arteries in the knee (geniculate artery embolization) can reduce pain and the need for opioid painkillers in people with knee osteoarthritis. Twelve participants will receive the procedure and be followed for a year with MRI scans and pai…

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study looks at whether core stability exercises or ankle and foot strengthening exercises can help people with knee osteoarthritis feel better. About 100 adults aged 40 and older with moderate knee osteoarthritis will take part. The goal is to see which type of exercise redu…

This Phase 2 trial tests a single injection of a gene therapy called PCRX-201 in 135 adults aged 45–80 with painful knee osteoarthritis. Participants receive one of two doses or a placebo, then are monitored for safety and pain relief over 5 years. The goal is to see if the injec…

This study tests whether an extended-release steroid injection (Zilretta) given during knee meniscus surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older are enrolled. Researchers will measure knee pain scores and inflammatory marke…

This pilot study tests whether the anti-inflammatory drug naproxen can reduce pain in people with knee osteoarthritis. Twenty participants will take naproxen or a placebo in a crossover design, meaning each person tries both treatments at different times. The study measures daily…

This study tests a new procedure called genicular artery embolization using SakuraBead, a dissolvable bead that blocks small blood vessels in the knee to reduce pain. It involves 89 adults aged 40-79 with moderate to severe knee osteoarthritis that hasn't improved with standard t…

This study looks at whether whole-body vibration training can improve body composition, muscle strength, walking speed, and pain in 30 older adults with knee osteoarthritis and sarcopenic obesity. Participants will do vibration exercises, and researchers will measure changes in p…

This study looks at whether combining two types of exercises—Feldenkrais and active release—with standard physical therapy can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40 to 60 with mild to moderate knee OA will do these exercises thr…

This study was designed to test a device called RELAY that delivers both local anesthetic and electrical nerve stimulation through a single catheter after knee surgery. The goal was to provide up to 28 days of pain control, longer than current options. However, the study was with…

This study looks at whether a 6-day course of oral steroids after orthopedic surgery can help reduce pain, nausea, and improve movement. About 500 adults having common surgeries like joint replacement or fracture repair will be randomly assigned to receive either standard care or…

This study tests a single injection of Arthrosamid, a hydrogel made mostly of water, in 29 people with painful knee osteoarthritis. The goal is to see if it improves daily activity and reduces symptoms over 12 months. Participants wear an activity tracker to measure changes, and …

This study compares robotic-assisted knee replacement to the traditional manual method in 100 people with severe knee arthritis. The goal is to see which approach leads to better knee alignment, movement, and patient satisfaction. Participants are randomly assigned to one of the …

This study tests whether adding blood flow restriction (a technique that gently limits blood flow to the legs) to walking on an anti-gravity treadmill can better reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 45-80 with knee arthritis wi…

This small, early study is testing a new device that uses low-frequency ultrasound waves in a bath to see if it can safely help heal knee osteoarthritis and reduce pain. Ten adults aged 40 and older with chronic knee pain will try the treatment every few days. The main goal is to…

This study tests whether adding a type of nerve stimulation (NESA or TENS) to a supervised exercise program can better reduce pain, improve function, and boost mental health in people over 60 with knee osteoarthritis. Over 8 weeks, 110 participants will receive either exercise pl…

This study looks at whether adding a dietary supplement to an exercise program can reduce pain and improve movement in people with knee osteoarthritis. About 93 adults with mild to moderate knee arthritis will be split into three groups: supplement alone, supplement plus exercise…

This study tests whether adding a special laser treatment (CO2 infrared laser moxibustion) to standard exercise can reduce knee pain and improve movement in people with knee osteoarthritis. About 68 adults aged 55-65 with knee arthritis will receive either exercise alone or exerc…

This study tests whether a single injection of a mix of platelet-rich plasma (from your own blood) and hyaluronic acid can safely reduce pain and improve function in people with moderate to severe knee osteoarthritis. About 280 adults with grade 3-4 knee arthritis will receive ei…

This study compares a mind-body approach called Basic Body Awareness Therapy (BBAT) to standard physiotherapy and home exercise for people with knee osteoarthritis. BBAT focuses on gentle, mindful movements to improve posture, balance, and pain management. Researchers will measur…

This study planned to test whether a 6-day course of oral methylprednisolone after total knee replacement could improve pain, sleep, and knee movement. Participants would also receive a steroid injection during surgery. The study was withdrawn before enrolling anyone, so no concl…

This study tests whether a disposable device called the Zero Degree Knee positioner helps people regain full knee extension faster after total knee replacement surgery. About 154 adults aged 40-80 with knee osteoarthritis will be randomly assigned to use the device at home or fol…

This study tests whether a procedure called genicular radiofrequency ablation can safely reduce persistent knee pain in people who still hurt more than a year after total knee replacement. The procedure uses heat to temporarily calm specific nerves around the knee. Half of the 44…

This study looks at whether adding a blood flow restriction cuff to targeted exercises helps adults aged 30-55 with mild to moderate knee osteoarthritis and bow legs feel less pain and move better. About 80 participants will be randomly assigned to do exercises either with or wit…

This study compares giving one dose of dexamethasone during knee replacement surgery versus two doses (one during surgery and one the next morning). The goal is to see which approach reduces pain, opioid use, and nausea while minimizing complications. About 339 adults undergoing …

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This study tests whether applying cabbage leaves to the knee can reduce pain, improve physical function, and boost quality of life in people with knee osteoarthritis. Researchers will compare two different cabbage leaf preparations against standard care in 90 adults over four wee…

This study looks at two different methods to reduce pain in people who have had knee replacement surgery due to arthritis. One method uses radiofrequency (heat) to calm the nerve, and the other uses a chemical called phenol. The goal is to see which works better and is safer. Abo…

This study tests whether using virtual reality (VR) during knee or hip surgery can help patients feel less anxious and need fewer sedating drugs. About 50 adults having surgery with a nerve block (awake but numb) will try VR and give feedback. The goal is to see if VR is a useful…

This study tests whether a special patch that delivers pulsed radiofrequency energy can reduce knee pain in people with osteoarthritis. Fifty adults aged 40-75 with chronic knee pain will receive either the real patch or a sham device. Researchers will measure pain and function o…

This study tests a behavioral program called Moving Well to see if it can reduce anxiety and depression in people waiting for knee replacement surgery. About 79 participants will either get the coaching program or a general wellness program. The goal is to improve emotional well-…

This study looks at two different non-surgical treatment plans for knee osteoarthritis in 300 military health system patients aged 18-60. The goal is to see which approach better improves physical function and reduces pain over one year. Participants will follow guidelines from t…

This study tests whether a home-based virtual reality system can help people with knee osteoarthritis do their physiotherapy exercises in a more engaging way. Fifty adults aged 45 and older with knee pain will be randomly assigned to either the VR program or standard physiotherap…

This study tests whether cutting a small nerve in the knee during a total knee replacement can reduce long-term pain. 178 adults having their first knee replacement will be randomly assigned to get either the standard surgery or the surgery plus the nerve cut. Researchers will tr…

This early-stage study tests a new gel containing ketoprofen, applied to the skin, for people with knee osteoarthritis. The goal is to see if it reduces pain and improves knee function. Forty adults with knee osteoarthritis will be randomly assigned to receive the gel or a compar…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This study tests whether a new physiotherapist-led primary care model can improve function and quality of life for adults with hip or knee pain. About 728 participants in Canada will be assigned to either the new model or usual care. The goal is to see if this approach reduces pa…

This study looks at two types of ultrasound-guided injections for people with knee osteoarthritis who haven't gotten relief from standard treatments like pills or physical therapy. One injection uses a chemical called phenol to block pain signals for a longer time, while the othe…

This study is testing a new computer-assisted navigation system for total knee replacement surgery in 126 adults with knee arthritis. The system helps surgeons place the artificial joint more accurately. Researchers will measure how well patients can use their knee 3 and 12 month…

This study tests a new knee brace designed to reduce joint pressure and a special low-intensity exercise method (blood flow restriction training) to strengthen leg muscles. Researchers will compare the new brace to a traditional one in 40 volunteers over 50 with knee osteoarthrit…

This study tests whether phone coaching and financial rewards can help people become more active after total knee replacement. 600 adults aged 40-85 will be split into three groups: usual care, activity tracker only, or activity tracker plus coaching and rewards. The goal is to s…

This study tests whether adding laser therapy to standard physiotherapy and exercise reduces knee osteoarthritis pain more than a sham (fake) laser plus exercise. Sixty-four adults with knee osteoarthritis will receive either real or sham laser treatments twice a week for six wee…

This study tests whether a guided exercise program done at home before knee replacement surgery can help people recover better. 84 adults scheduled for knee replacement will be asked to do simple exercises daily from the day they are admitted until surgery. Researchers will measu…

This study tests a new injectable treatment called Neural Ice that uses cold energy to reduce chronic knee pain from osteoarthritis. About 263 adults aged 22 to 80 with moderate to severe pain will receive the injection and be monitored for 6 months. The goal is to see if it prov…

This study tests a new procedure called genicular artery embolization (GAE) against standard steroid injections for people with knee osteoarthritis. The goal is to see if blocking certain arteries with tiny beads can provide better pain relief than steroid shots. The trial involv…

This study tests whether a treatment called dorsal root ganglion stimulation (DRG-S) can reduce chronic knee pain caused by osteoarthritis. About 30 adults with long-term knee pain who have not had surgery or are not good candidates for it will receive a device that sends mild el…

This study tests whether the steroid hydrocortisone can improve knee movement after total knee replacement. About 132 patients, some with naturally stiff knees, will receive either the drug or a placebo right after surgery. Researchers will measure how well the knee bends and str…

This study tested whether two types of gentle brain stimulation (tDCS and TUS) can reduce pain and improve daily function in people with chronic knee osteoarthritis. 64 adults with persistent knee pain received either real or sham stimulation. Researchers measured changes in pain…

This study tested a stem cell treatment for one person with severe, long-term knee pain from osteoarthritis who had no other options left. The patient received stem cells from their own fat, given both through a vein and directly into the knee joints. The goal was to see if the t…

This study was designed to test whether PG201, a botanical drug, could reduce pain and improve function in people with knee osteoarthritis. It planned to enroll Korean adults aged 40 to 75 and compare two doses of PG201 against a placebo over 8 weeks. However, the trial was withd…

This study tests whether a special type of platelet-rich plasma (PRP) injection, called biofiller PRP, can reduce pain, improve movement, and enhance quality of life in people with knee osteoarthritis. Sixty participants aged 45-65 with moderate knee arthritis will receive the in…

This study tests whether turmeric extract capsules can lower inflammation and pain in people with knee osteoarthritis. 72 adults will take either turmeric or a placebo daily for 3 weeks. Researchers will measure pain and inflammatory markers in the blood.

This pilot study tests whether taking a daily vitamin K supplement can improve leg function in adults with mild to moderate knee osteoarthritis. Researchers will give 37 participants either vitamin K or a placebo for 6 months. The main goal is to gather information needed to desi…

This study was designed to see if a Botox injection into the knee joint could relieve arthritis pain better than a steroid injection. Researchers planned to use special MRI scans to measure inflammation. However, the trial was withdrawn before enrolling any participants, so no re…

This study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve function. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will be followed for 6 m…

This study follows up to 500 people with acute or chronic inflammatory disorders, such as infections or immune problems, over time. Researchers will monitor participants with standard tests and may screen them for other studies. The goal is to better understand these conditions a…

This study aims to validate a new questionnaire that measures emotional wellbeing and patient perceptions after total knee replacement surgery for knee arthritis. Researchers will enroll 167 adults who had knee replacement within the last 3 months. The goal is to ensure the quest…

This study looks at whether a 3-month non-surgical program—including patient education, supervised exercise, and diet counseling—can help people with knee osteoarthritis avoid knee replacement surgery while maintaining their quality of life. Researchers will follow 2,500 patients…

This study was designed to see if X-rays taken before knee replacement surgery could reliably show ligament damage in people with knee arthritis. It was an observational study, meaning no treatment was given. However, the study was withdrawn before enrolling any participants, so …

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study follows over 1,500 people who received an Attune total knee replacement to see how long the implant lasts—up to 15 years. Participants had non-inflammatory degenerative joint disease (like osteoarthritis). The goal is to gather real-world data on the durability of four…

This study follows 200 people who received a smart knee implant (Persona IQ) that tracks movement after total knee replacement. The goal is to see if data from the implant and a phone app can help doctors understand recovery and spot problems early. Participants use a smartphone …

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study collects blood, urine, and tissue samples from 330 adults with advanced lung or head and neck cancer to improve precision medicine. Researchers will analyze genetic changes in these samples and grow some tumors in mice to compare DNA. The goal is to refine liquid biops…

This study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer question…

This early-stage study tests a handheld imaging device that uses magnetic particles to track stem cells after they are injected into the knee. Ten adults with mild-to-moderate knee osteoarthritis will receive a single injection of labeled stem cells, and the device will monitor t…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study looks at whether using an activity tracker with motivational feedback helps people become more active after knee replacement surgery compared to using a tracker without feedback. About 152 adults aged 40-85 scheduled for knee replacement will take part. The goal is to …

This study aimed to compare knee movement in people who had one of two different total knee replacements. Researchers planned to measure how the knee bends and shifts during activities like stepping up and deep knee bends. The study was withdrawn before any participants were enro…

This study reviewed records of 166 knee replacement patients who received a nerve block for pain. Researchers compared pain scores 6-24 hours after the block wore off between two groups: one that received extra education about pain management before surgery and one that did not. …

This study looks at how the quality and movement of thigh muscles relate to pain, daily function, and quality of life in women with knee osteoarthritis. About 58 women aged 40-70 will have a painless ultrasound of their thigh muscles and fill out questionnaires. The goal is to be…

This study is tracking 120 people who received a HYPE SCS hip stem during total hip replacement. Researchers will monitor how long the implant lasts, how satisfied patients are, and any complications over 5 years. The goal is to confirm the device is safe and works as intended in…

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study looks at whether adding an extra nerve block to the usual pain block can reduce inflammation after total knee replacement. Researchers will measure inflammation markers in the blood of 60 adults. The goal is to see if this approach leads to less pain medicine use and b…

This study looks at whether using a patient decision aid during doctor visits helps people with severe hip or knee osteoarthritis make better choices about surgery. Researchers will track how informed patients feel, their involvement in decisions, and their pain, function, and qu…

This study looks at three different knee replacement designs: one that keeps the ACL, one that substitutes for it, and one that sacrifices it. Researchers want to see which design gives the best function, pain relief, and satisfaction in 75 people with severe knee arthritis. Part…

This study follows 88 working-age adults (63 or younger) who had knee replacement surgery to see when and how many return to work. Researchers track pain, knee function, and work ability using questionnaires over 1.5 years. The goal is to identify factors that help or hinder retu…

This study aimed to see if a 4-week running form retraining program could reduce knee pain and improve function in runners with mild to moderate knee osteoarthritis. It planned to measure changes in symptoms and knee joint loads. However, the study was withdrawn before any partic…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study looks at 219 people who had ACL reconstruction surgery about 10 years ago. Researchers will use MRI scans to check the health of the knee cartilage and compare it to the uninjured knee. The goal is to learn more about how osteoarthritis develops after a knee injury.

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study compares having both knees replaced at the same time versus one after the other in people with knee osteoarthritis. About 224 participants will be randomly assigned to one approach. Researchers will track recovery, joint function, and quality of life to help guide pati…

This study involves 100 people with knee osteoarthritis to compare different ways of measuring knee function, including patient questionnaires and physical tests like walking and standing. The goal is to understand how subjective reports and objective performance relate to each o…

This study looks at how hot bone gets during total knee replacement surgery when using a burr (robotic) versus a saw (conventional). Twenty patients will have their bone temperature measured with an infrared thermometer during the procedure. The goal is simply to compare the heat…

This study looks at how seeing or not seeing affects knee joint position sense in people with knee osteoarthritis. Researchers will measure how accurately 120 participants can position their knee with and without visual input. The goal is to better understand how the brain senses…

This study asks over 2,300 people with various joint conditions (like arthritis, fractures, and hip problems) to fill out surveys about their treatment preferences. Researchers want to learn how factors like pain, recovery time, cost, and surgery versus non-surgery affect patient…

This study surveys 384 physiotherapists in Pakistan to find out which rehabilitation approaches they use after total knee replacement. The goal is to identify common practices, variations, and challenges. Results may help standardize care and improve recovery for future patients.

This study looks at whether using a 3D patient-specific alignment during knee replacement surgery leads to better walking, less pain, and stronger muscles. Researchers will measure movement, pain, and strength in 45 adults who had surgery two years ago. The goal is to understand …

This study compares robot-assisted knee replacement to the standard manual technique in 50 patients with partial knee arthritis. The goal is to see which method better prevents early implant loosening, measured with special X-rays. Participants will be followed for two years afte…

This study follows 124 golfers who have hip, knee, or shoulder replacement surgery. Researchers track how many return to golf, how long it takes, and how their game and joint function change over a year. The goal is to give patients and doctors clear, realistic expectations about…

This study looked at 104 people having knee replacement surgery to see if removing the surgical drain before or after starting gentle knee movement exercises (called continuous passive motion) reduces fluid buildup. The goal is to find the best timing to help healing and reduce s…

This study looks at why people with bone cancer (skeletal sarcoma) get more infections after joint replacement surgery than those with arthritis. Researchers will collect tissue and blood samples from 40 patients to compare immune and bacterial factors. The goal is to understand …

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study looks at whether watching the steps to prepare a platelet-rich plasma (PRP) injection for knee osteoarthritis changes how well patients think it works. About 158 adults aged 50 to 80 with knee osteoarthritis will be involved. Some will watch the preparation, others wil…