New knee injection aims to ease arthritis pain and improve mobility

NCT ID NCT06865079

Ongoing Disease control Sponsor: OrthoTrophix, Inc Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 29 times

Summary

This study tests whether injections of a drug called TPX-100 can safely reduce pain and improve function in people with mild to severe knee osteoarthritis. About 270 adults aged 50 to 80 will receive either TPX-100 or a placebo shot into the knee joint and be followed for 53 weeks. The goal is to see if TPX-100 can help control the disease and ease symptoms, but it is not expected to cure the condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AMR Kansas City

Kansas City, Kansas, 64114, United States
AMR Knoxville

Knoxville, Tennessee, 37909, United States
AMR Lexington

Lexington, Kentucky, 40509, United States
Accurate Clinical Research

Houston, Texas, 77089, United States
Accurate Clinical Research Inc.

Lake Charles, Louisiana, 70605, United States
Accurate Clinical Research, LLC

Baytown, Texas, 77521, United States
Albuquerque Clinical Trials

Albuquerque, New Mexico, 87102, United States
CORE Orthopaedic Medical Center

Encinitas, California, 92024, United States
CenExel

Salt Lake City, Utah, 84107, United States
Center for Clinical Research

Winston-Salem, North Carolina, 27103, United States
Drug Studies of America

Marietta, Georgia, 30060, United States
Elite Clinical Network

Scottsdale, Arizona, 85260, United States
Endeavor Clinical Trials

San Antonio, Texas, 78229, United States
First Surgical Hospital

Bellaire, Texas, 77401, United States
Hightower Clinical

Oklahoma City, Oklahoma, 73102, United States
K2 Medical Research

Maitland, Florida, 32751, United States
Las Mercedes Medical Research

Miami, Florida, 33196, United States
Las Vegas Clinical Trials

North Las Vegas, Nevada, 89030, United States
Legent Orthopedic Hospital

Carrolton, California, 75006, United States
Marvel Clinical Research (Elite Clinical Network)

Huntington Beach, California, 92647, United States
Mayo Clinic (Rochester)

Rochester, Minnesota, 55905, United States
Medvin Clinical Research

Covina, California, 91722, United States
Medvin Clinical Research Center

Riverside, California, 92518, United States
Medvin Clinical Research Center

Tujunga, California, 91042, United States
Medvin Clinical Research Center

Whittier, California, 90602, United States
Noble Clinical Research

Tucson, Arizona, 85704, United States
Texas Orthopedic Specialist

Bedford, Texas, 76021, United States
University Orthopedics Center

Altoona, Pennsylvania, 16602, United States
University Orthopedics Center

State College, Pennsylvania, 16801, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
Wasatch Clinical Research

Salt Lake City, Utah, 84107, United States
Well Pharma Medical Research

Miami, Florida, 33173, United States
Wellness Research Center

Miami, Florida, 33135, United States

Conditions

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OSTEOARTHRITIS (OA) OF THE KNEE