Vitamin k supplement shows promise for knee arthritis in early trial

NCT ID NCT05505552

Ongoing Symptom relief Sponsor: Tufts University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study tests whether taking a daily vitamin K supplement can improve leg function in adults with mild to moderate knee osteoarthritis. Researchers will give 37 participants either vitamin K or a placebo for 6 months. The main goal is to gather information needed to design a larger, more definitive study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin K (phylloquinone)
What this could lead to: If it works, this could point toward a simple, low-cost supplement to help maintain mobility in people with knee osteoarthritis.
What could go wrong: This is a very small pilot study with only 37 participants, designed mainly to gather data for a future larger trial. It is not designed to prove that vitamin K works, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEO ARTHRITIS KNEE

Contacts and locations

Locations

Tufts University

Boston, Massachusetts, 02111, United States
UMass Memorial Medical Center

Worcester, Massachusetts, 01605, United States
University of North Carolina Chapel Hill

Chapel Hill, North Carolina, 27599, United States

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