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Could a single injection rebuild knees? phase 3 trial underway

NCT ID NCT03203330

Ongoing Disease control Sponsor: Kolon TissueGene, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests a single injection of TG-C, a cell-based treatment, in 535 people with moderate knee osteoarthritis. The goal is to see if it reduces pain and improves knee function compared to a placebo injection. Participants are followed for two years to check safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
TG-C (TissueGene-C) – a single injection of cells that release a growth factor to help repair knee cartilage
What this could lead to
If it works, this could provide a new, non-surgical treatment option for knee osteoarthritis that reduces pain and improves knee function.
What could go wrong
This is an early Phase 3 trial, so results are not yet confirmed. The treatment may not work better than placebo, and there could be side effects from the injection or the cells.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthropathy osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE OSTEOARTHRITIS

Contacts and locations

Locations

  • Adil Fatakia

    Marrero, Louisiana, 70072, United States

  • Alan Kivitz

    Duncansville, Pennsylvania, 16635, United States

  • Aldo Maspons

    El Paso, Texas, 79225, United States

  • Amr Morsy

    Dallas, Texas, 75240, United States

  • Anand Patel

    Winter Park, Florida, 32789, United States

  • Arthur Mabaquiao

    San Diego, California, 92108, United States

  • Aurelio Torres-Consuegra

    Miami, Florida, 33144, United States

  • Bradly Goodman

    Birmingham, Alabama, 35235, United States

  • Brett Gilbert

    Durham, North Carolina, 27704, United States

  • Brian MacGillivray

    San Antonio, Texas, 78258, United States

  • Cathy Barnes

    New Port Richey, Florida, 34652, United States

  • Dan La

    Covina, California, 91722, United States

  • Daneshvari Solanki

    Bellaire, Texas, 77401, United States

  • David Billmeier

    Daytona Beach, Florida, 32117, United States

  • Dennis Levinson

    Chicago, Illinois, 60607, United States

  • Diraj Karnani

    Apple Valley, California, 92307, United States

  • Edgar Gonzalez

    Miami, Florida, 33144, United States

  • Edward Tavel

    Columbia, South Carolina, 29206, United States

  • Eric Grigsby

    Napa, California, 94558, United States

  • Eric Loudermilk

    Greenville, South Carolina, 29601, United States

  • Haresh Boghara

    DeSoto, Texas, 75115, United States

  • Harvey Bowles

    Nashville, Tennessee, 37203, United States

  • Howard Chipman

    Oldsmar, Florida, 34677, United States

  • Hythem Shadid

    Oak Brook, Illinois, 60523, United States

  • James Nace

    Baltimore, Maryland, 21215, United States

  • Jason Oh

    New York, New York, 10075, United States

  • Jeffrey Davis

    Birmingham, Alabama, 35205, United States

  • Jeremy Hoff

    Wilmington, North Carolina, 28412, United States

  • John Hemmersmeier

    South Ogden, Utah, 84405, United States

  • Kristen Holtz

    Charlottesville, Virginia, 22901, United States

  • Manish Jain

    Chicago, Illinois, 60640, United States

  • Mark Hermann

    Danville, Virginia, 24541, United States

  • Mehul Desai

    Washington D.C., District of Columbia, 20006, United States

  • Melvin Churchill

    Lincoln, Nebraska, 68516, United States

  • Mercedes Ponce De Leon

    Miami, Florida, 33135, United States

  • Nebojsa Skrepnik

    Tucson, Arizona, 85712, United States

  • Richard Linn

    Sunrise, Florida, 33351, United States

  • Saima Chohan

    Phoenix, Arizona, 85032, United States

  • Sandeep Vaid

    Newnan, Georgia, 30265, United States

  • Scott Hacker

    La Mesa, California, 91942, United States

  • Subodh Bhuchar

    Houston, Texas, 77099, United States

  • Tien-I Su

    Whittier, California, 90602, United States

  • Timothy Davis

    Santa Monica, California, 90403, United States

  • Yogesh Mittal

    Tulsa, Oklahoma, 74104, United States

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