New drug could replace opioids for knee surgery pain
NCT ID NCT07219888
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a new drug called suzetrigine can control pain after knee replacement surgery as well as oxycodone, a common opioid. About 140 adults with knee osteoarthritis will receive either suzetrigine or oxycodone for two weeks after surgery. Researchers will track pain levels and how much opioid medication each group needs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- suzetrigine
- What this could lead to
- If suzetrigine works well, it could offer a new pain relief option after knee surgery that may reduce the need for opioids.
- What could go wrong
- This is a small, early-phase study (140 people) comparing a new drug to a standard one. Suzetrigine may not be as effective or could have side effects not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UofL Health
Louisville, Kentucky, 40202, United States
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