New drug could replace opioids for knee surgery pain
NCT ID NCT07219888
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a new drug called suzetrigine can control pain after knee replacement surgery as well as oxycodone, a common opioid. About 140 adults with knee osteoarthritis will receive either suzetrigine or oxycodone for two weeks after surgery. Researchers will track pain levels and how much opioid medication each group needs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
suzetrigine
What this could lead to
If suzetrigine works well, it could offer a new pain relief option after knee surgery that may reduce the need for opioids.
What could go wrong
This is a small, early-phase study (140 people) comparing a new drug to a standard one. Suzetrigine may not be as effective or could have side effects not yet known.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UofL Health
Louisville, Kentucky, 40202, United States