New painkiller aims to replace opioids after knee surgery

NCT ID NCT07219888

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 25 times

Summary

This study compares a new pain medicine called suzetrigine to the standard opioid oxycodone for pain after total knee replacement. About 140 adults with knee osteoarthritis will take either suzetrigine or oxycodone for two weeks after surgery. Researchers will measure pain levels and how much extra opioid pain medicine is needed, to see if suzetrigine can control pain with fewer opioids.

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Contacts and locations

Locations

  • UofL Health

    Louisville, Kentucky, 40202, United States

Conditions

Explore the condition pages connected to this study.