Freeze your knee pain away? new cold injection trial aims to ease arthritis

NCT ID NCT06700109

Ongoing Symptom relief Sponsor: Brixton Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new injectable treatment called Neural Ice that uses cold energy to reduce chronic knee pain from osteoarthritis. About 263 adults aged 22 to 80 with moderate to severe pain will receive the injection and be monitored for 6 months. The goal is to see if it provides safe and lasting pain relief without surgery or long-term medication.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS (OA) OF THE KNEE

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Centers for Advanced Orthopedics

Washington D.C., District of Columbia, 20036, United States
Clinical Investigations, LLC

Edmond, Oklahoma, 73034, United States
Emory University

Johns Creek, Georgia, 30097, United States
Insight Hospital and Medical Center Chicago

Chicago, Illinois, 60616, United States
Insight Research Institute

Flint, Michigan, 48507, United States
Marin Health

Larkspur, California, 94939, United States
NextStage Clinical Research Advanced Orthopaedic Associates

Wichita, Kansas, 67226, United States
NextStage Clinical Research All-American Orthopedic & Sports Medicine Institute

Houston, Texas, 77058, United States
NextStage Clinical Research Regenerative Orthopedics and Sports Medicine

North Bethesda, Maryland, 20852, United States
NextStage Clinical Research The Orthopedic Center

Tulsa, Oklahoma, 74104, United States
Ochsner Health System

New Orleans, Louisiana, 70115, United States
Pain Diagnostics and Interventional Care

Sewickley, Pennsylvania, 15143, United States
The Orthopaedic Institute

Gainesville, Florida, 32607, United States
UT San Antonio

San Antonio, Texas, 78229, United States

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