Knee implant shows promise in repairing cartilage damage
NCT ID NCT03299959
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new implant called Agili-C for people with knee cartilage damage or early arthritis. 251 participants received either the implant or standard surgery. The goal was to see if the implant improved pain and function over 5 years. Results suggest it may be a helpful option for some patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Agili-C implant
- What this could lead to
- If successful, this implant could offer a better option for people with knee cartilage damage, reducing pain and improving mobility without needing a full knee replacement.
- What could go wrong
- This is a completed trial, but results may not apply to everyone. The implant is a device, so risks include infection, implant failure, or no improvement over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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"Carmel" Medical Center
Haifa, 3436212, Israel
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AZ Monica
Antwerp, Belgium
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Arlington Orthopedic Associates
Arlington, Texas, 76015, United States
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Assaf Harofeh Medical Center
Be’er Ya‘aqov, 60930, Israel
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Atlas General hospital
Belgrade, Serbia
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Brigham and Women's Hospital
Boston, Massachusetts, 02467, United States
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Clinic for Orthopedic Surgery "Banjica"
Belgrade, Serbia
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Clinical Center of Vojvodina
Novi Sad, Serbia
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County Hospital Timis Othopedy and Trauma Clinic
Timișoara, Romania
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Hadassah Medical Center
Jerusalem, Israel
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Hasharon Hospital, Petach Tikva
Petah Tikva, Israel
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Horizon Clinical Research
San Diego, California, 91942, United States
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Hospital for Special Surgery
New York, New York, 10021, United States
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Humanitas Gavazzeni
Bergamo, Italy
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Istituto Clinico Humanitas
Rozzano, Italy
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Kastélypark Klinika
Tata, 2892, Hungary
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LSU Healthcare Network Orthopedic & Sports Medicine
New Orleans, Louisiana, 70112, United States
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NYU Langone Orthopedic Hospital
New York, New York, 10003, United States
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Ohio State University, Wexner Medical Center
Columbus, Ohio, 43210, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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OrthoVirginia
Richmond, Virginia, 23294, United States
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Peninsula Orthopaedic Associates
Salisbury, Maryland, 21804, United States
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Souraski Medical Center
Tel Aviv, 6423906, Israel
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Specialist Hospital. Louis Rydygier in Krakow
Krakow, Poland
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University of Missouri, Missouri Orthopaedic Institute
Columbia, Missouri, 65212, United States
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Uzsoki Utcai Kórház
Budapest, 1114, Hungary
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Other studies related to the condition(s) this trial covers.