New knee shot aims to ease arthritis pain – early trial underway

NCT ID NCT06989645

Completed Symptom relief Sponsor: Synartro AB Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested a single injection of SYN321, a drug that breaks down into pain-relieving substances, in 35 people with painful knee osteoarthritis. The main goal was to check safety and tolerability at three different doses compared to a placebo injection. Researchers also looked at how the drug moves through the body and whether it offers any pain relief, but the study was too small to draw firm conclusions about effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SYN321 (a drug that breaks down into diclofenac and diclofenac lactam)
What this could lead to: If it works, this could point toward a single-injection treatment to ease knee osteoarthritis pain for weeks or months.
What could go wrong: This is a very early, small trial (35 people) focused on safety, not proof of effectiveness. The drug may not reduce pain better than placebo, and side effects are still being identified.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis susceptibility 6 osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS OF KNEE

Contacts and locations

Locations

Cinical Trial Consultants AB

Uppsala, Sweden

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