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New shot could ease knee pain for millions with arthritis

NCT ID NCT07226258

Symptom relief Sponsor: Saol Therapeutics Inc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 4 times

Summary

This study tests a single injection called SL1002 to see if it safely reduces knee pain in people with osteoarthritis. About 150 adults aged 40 and older with mild to moderate knee arthritis will receive either the study drug or a placebo. The main goal is to measure pain relief while walking after 12 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria includes: 1. Male or female patients ≥ 40 years of age 2. Body Mass Index (BMI) limits 3. Chronic knee pain resulting from osteoarthritis 4. Kellgren-Lawrence Grade 2 (mild) or Grade 3 (moderate) 5. Baseline KOOS pain 6. Patients taking baseline analgesics 7. Diagnostic nerve block response 8. Compliance with identified study requirements Exclusion Criteria includes: 1. Non-OA inflammatory arthritis 2. Confounding elements 3. Lower limb amputation. 4. Specified alternate historic treatments 5. Identified underlying physiologic or psychosocial conditions 6. Patient Health Questionnaire 7. Moderate to severe hepatic impairment 8. Moderate to severe renal impairment 9. Identifiable baseline medications 10. Protocol compliance requirements 11. Known allergies or hypersensitivity to identified agents 12. Identified alcohol or drug abuse history 13. Identified underlying physical exam findings: ECG abnormalities or vital sign abnormalities during study screening per investigator assessment 14. Identified underlying abnormal laboratory results

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis knee pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    22 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Comprehensive Specialty Care

    RECRUITING

    Edmond, Oklahoma, 73034, United States

    Contact Email: •••••@•••••

  • Conquest Research, LLC

    RECRUITING

    Orlando, Florida, 32832, United States

    Contact Email: •••••@•••••

  • Conquest Research, LLC

    RECRUITING

    Winter Park, Florida, 32789, United States

    Contact Email: •••••@•••••

  • DBPS Research, LLC

    RECRUITING

    Greenwood Village, Colorado, 80111, United States

    Contact Email: •••••@•••••

  • Innovative Pain Treatment Solutions

    RECRUITING

    San Diego, California, 92111, United States

    Contact Email: •••••@•••••

  • Institute of Precision Pain Medicine

    RECRUITING

    Corpus Christi, Texas, 78414, United States

    Contact Email: •••••@•••••

  • International Spine, Pain & Performance Center

    RECRUITING

    Washington D.C., District of Columbia, 20006, United States

    Contact Email: •••••@•••••

  • International Spine, Pain & Performance Center (IPP)

    RECRUITING

    Tyler, Texas, 75701, United States

    Contact Email: •••••@•••••

  • Interventional Pain Institute

    RECRUITING

    The Villages, Florida, 32159, United States

    Contact Email: •••••@•••••

  • Legent Orthopedic and Spine Hospital

    RECRUITING

    Bellaire, Texas, 77401, United States

    Contact Email: •••••@•••••

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

  • Medical University of South Carolina (MUSC)

    RECRUITING

    Charleston, South Carolina, 29425, United States

    Contact Email: •••••@•••••

  • PCPMG Clinical Research Unit, LLC

    RECRUITING

    Greenville, South Carolina, 29601, United States

    Contact Email: •••••@•••••

  • Pacific Sports and Spine

    RECRUITING

    Eugene, Oregon, 97404, United States

    Contact Email: •••••@•••••

  • Pain Diagnostics & Interventional Care LLC

    RECRUITING

    Sewickley, Pennsylvania, 15143, United States

    Contact Email: •••••@•••••

  • Prime Medical Research

    RECRUITING

    Coral Gables, Florida, 33134, United States

    Contact Email: •••••@•••••

  • Queen City Clinical Research, PLLC

    RECRUITING

    Charlotte, North Carolina, 28211, United States

    Contact Email: •••••@•••••

  • Sutter Neurology and Pain Management

    RECRUITING

    Roseville, California, 95661, United States

    Contact Email: •••••@•••••

  • The Center for Clinical Research

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

    Contact Email: •••••@•••••

  • University Orthopedics Center

    RECRUITING

    Altoona, Pennsylvania, 16602, United States

    Contact Email: •••••@•••••

  • University of Utah Orthopedic Center

    RECRUITING

    Salt Lake City, Utah, 84108, United States

    Contact Email: •••••@•••••

  • Virginia iSpine Physicians, PC

    RECRUITING

    Richmond, Virginia, 23238, United States

    Contact Email: •••••@•••••