New study aims to ease knee surgery pain without opioids

NCT ID NCT07130552

Recruiting now Symptom relief Sponsor: Karaman Training and Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two different nerve block combinations to control pain after total knee replacement. 120 adults will receive either a popliteal plexus block or a distal IPACK block, both combined with a femoral triangle block. The goal is to see which approach reduces opioid use and improves early recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine
What this could lead to: If successful, this could identify a better nerve block technique to reduce pain and opioid use after knee replacement surgery.
What could go wrong: This is a small, early-stage study (120 people) comparing two similar techniques. The results may not apply to all patients, and there is a risk of nerve block side effects like weakness or rare allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEO ARTHRITIS OF THE KNEE

Contacts and locations

Locations

Karaman Training and Research Hospital, Karaman, Karaman 70200
RECRUITING

Karaman, 70200, Turkey (Türkiye)

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