One shot, one year: could a single injection ease knee arthritis pain?
NCT ID NCT07736781
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether a single injection of hyaluronic acid into the knee can reduce pain and improve function in people with moderate knee osteoarthritis over 12 months. The study includes adults aged 40 to 75 who have persistent knee pain despite standard treatments like NSAIDs or physical therapy. Researchers will track pain scores, mobility, and quality of life at regular checkups to see if this one-time procedure offers lasting relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a single injection of hyaluronic acid (brand name Diart) into the affected knee
- What this could lead to
- If it works, this could offer a simple, one-time injection to ease knee pain and improve mobility for months, reducing the need for daily painkillers.
- What could go wrong
- This is a small, single-arm trial with no placebo group, so results may be less reliable. Hyaluronic acid injections can cause temporary joint pain or swelling, and not everyone responds.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital Univerisiti Sains Malaysia (HUSM)
Kota Bharu, Kelantan, 16150, Malaysia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Robotic vs. manual knee alignment: which is better for heavier patients?
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- New knee injection polymer put to the test in first human trial
- Robot vs surgeon: which knee replacement works better?