OSTEO ARTHRITIS OF THE KNEE

This study tests a single injection of Hydrogel OA 2% in 20 adults with knee osteoarthritis. The goal is to see if the gel is safe and tolerable over 13 weeks to 12 months. Participants must be 35–75 years old with a BMI between 20 and 35.

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study tests two different nerve block combinations to control pain after total knee replacement. 120 adults will receive either a popliteal plexus block or a distal IPACK block, both combined with a femoral triangle block. The goal is to see which approach reduces opioid use…

This study tests whether the BETY exercise program, which combines physical exercises with pain management and emotional support, can help people with knee osteoarthritis who recently received injections. Sixty adults with knee osteoarthritis will be enrolled. The goal is to see …

This study tests a portable, seated leg dexterity trainer designed to improve knee control and reduce pain in people with knee osteoarthritis. About 82 adults aged 40-85 with knee OA will use either the new device or a wobble board at home for 8 weeks. The goal is to see if the d…

This study tests a minimally invasive treatment for chronic knee pain from osteoarthritis or after knee replacement. Doctors guide a thin tube to knee arteries and inject a temporary agent to reduce blood flow to inflamed tissue. The goal is to see if this procedure safely reduce…

This study tests whether high-intensity pulsed electromagnetic field (HI-PEMF) therapy can reduce pain and improve strength in older adults with knee osteoarthritis. 64 participants will receive HI-PEMF on the knee alone or on both the knee and thigh muscle, plus a home exercise …

This study tests whether methotrexate, a drug used for rheumatoid arthritis, can reduce pain and swelling in people with knee osteoarthritis who also have joint inflammation (synovitis). Seventy adults aged 40–70 will receive either methotrexate or a placebo for 6 months. Researc…