University Hospital, Clermont-ferrand

This study tested whether using lung CT images to guide ventilator settings could reduce deaths in people with ARDS. 420 adults were assigned to either standard ventilator care or a strategy based on their lung morphology. The goal was to see if personalized ventilation could imp…

This study tested whether using a lung ultrasound score to decide on breathing support (high-flow nasal oxygen or noninvasive ventilation) after removing a breathing tube could reduce breathing distress in ICU patients. 483 adults who had been on a ventilator for more than 48 hou…

This study tested whether inhaling sevoflurane, a gas usually used for anesthesia, for the first 48 hours could improve oxygen levels and reduce inflammation in 50 adults with moderate to severe ARDS. Participants were randomly assigned to receive either sevoflurane or a standard…

This study tested two different ways of using a breathing machine during emergency abdominal surgery. One method used higher air pressure to keep the lungs open, while the other used lower pressure to avoid overstretching the lungs. The goal was to see which approach led to fewer…

This study tested whether using sevoflurane (an inhaled anesthetic) for sedation could lower death rates and shorten time on a ventilator in patients with acute respiratory distress syndrome (ARDS). 700 adults were randomly assigned to receive either sevoflurane or standard propo…

This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiaz…

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could sa…

This study tested a new combination test called Premaquick, which measures three markers in vaginal fluid, to see if it can better predict whether a woman with threatened preterm labor will deliver within 7 days. Researchers compared it to the standard fetal fibronectin test in 2…

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested whether curcumin, the active ingredient in turmeric, can prevent Crohn's disease from coming back after surgery. 61 adults who had recent surgery for Crohn's were given either curcumin or a placebo, along with standard thiopurine drugs, for 6 months. The goal wa…

This study tested whether adding an oral antibiotic (ornidazole) the day before colorectal surgery to the standard IV antibiotic given at incision time could reduce surgical site infections within 30 days. Over 900 adults having elective colorectal surgery took part. The goal was…

This study looked at whether sophrology, a relaxation method using breathing, muscle relaxation, and mental imagery, can help lower stress. Researchers followed 60 adults—some who practiced sophrology weekly and some who did not—for several months. They measured stress using both…

This study tested whether the sedative dexmedetomidine can reduce how long non-intubated ICU patients experience agitated delirium. Researchers randomly gave 168 patients either dexmedetomidine or a placebo. The goal was to see if the drug shortens agitation and delirium, and red…

This study tested whether wearing a virtual reality mask during blood draws and allergy skin tests helps children aged 7 to 13 feel less pain and anxiety. About 300 kids from two hospitals took part. The goal was to see if distracting them with VR makes these procedures easier to…

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested whether ethosuximide, a drug used for epilepsy, can reduce belly pain in people with irritable bowel syndrome (IBS). 162 adults with IBS took either the drug or a placebo. The goal was to see if the drug could lower pain and improve quality of life.

This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadr…

This study tested whether ethosuximide, a drug already used for epilepsy, can reduce pain in people with nerve damage. 114 adults with peripheral neuropathic pain took either the drug or a placebo for 42 days. Researchers measured pain levels and quality of life to see if the dru…

This study tested whether botulinum toxin (Botox) injections can reduce head shaking in people with essential head tremor, a condition that often doesn't respond to standard medicines or surgery. About 120 adults with troublesome head tremor received either Botox or a placebo sho…

This study compared two surgical techniques for removing the uterus (hysterectomy) due to non-cancerous conditions: the newer vNOTES method (done through the vagina) and standard laparoscopy (keyhole surgery). 145 women took part, and researchers tracked complications, pain, and …

This study tested whether adding virtual reality (VR) to standard smoking cessation treatment helps people quit. 74 smokers who wanted to stop received nicotine patches and either usual counseling or VR-enhanced therapy. The goal was to see if VR could reduce cravings and improve…

This study looked at two different surgical methods for replacing the shoulder joint in people over 65 who had a severe shoulder fracture. The goal was to see which approach leads to better shoulder function, safety, and quality of life. 90 participants were randomly assigned to …

This study looked at 80 adults with a broken upper arm bone who needed surgery to place a metal nail inside the bone. Researchers compared the usual method (going through the rotator cuff) with a newer method (going through a gap called the rotator interval). The goal was to see …

This study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …

This study tested whether wearing a virtual reality headset during botulinum toxin injections could lower stress and pain in adults with muscle spasticity. Forty-two participants chose calming audio-visual content while getting their shots. Researchers measured heart rate variabi…

This study looks at people with a rare inherited condition called dysfibrinogenemia, which affects how blood clots form. Researchers collected blood samples from 70 patients to analyze clot structure and search for genetic variations that might explain why some patients bleed whi…

This study looked at how a blend of plant and whey protein, combined with a 12-week exercise program, affects protein digestion and muscle health in 15 inactive older adults. Researchers measured how the body uses amino acids from meals and checked muscle tissue markers. The goal…

This study aimed to find simple ways to predict how much pain people will feel after oral surgery, like having a tooth pulled. Researchers measured things like pain sensitivity before the procedure in 148 adults. The goal was to create a model that helps doctors plan better pain …

This study tested whether a personalized approach to removing breathing tubes in the ICU works better than standard care. About 691 adults on ventilators for over 24 hours were included. Doctors used daily checks and chose the best method (T-piece or pressure support) based on ea…

This study looked at 332 stroke patients to see if general anesthesia or conscious sedation is better during a procedure to remove blood clots from the brain. The goal was to find which method leads to better recovery and fewer complications within the first week. The results cou…

This study looked at two ways of pushing during the final stage of labor: holding your breath while pushing (Valsalva) versus pushing while exhaling (open-glottis). Researchers wanted to see which method leads to fewer injuries and better outcomes for both mother and baby. A tota…

This study of 60 people with cirrhosis measured quadriceps (thigh) strength and compared it to standard frailty and malnutrition scores. The goal was to see if a simple leg strength test could replace more complex frailty assessments. No treatment was given; it was purely an obse…

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire, which measures how oral health affects daily life. Researchers enrolled 200 French-speaking adults, including people with gum disease and healthy controls. Participants filled out the quest…

This study tests a French version of a questionnaire that measures how dentin hypersensitivity (sharp, brief tooth pain) affects people's daily lives. Researchers enrolled 216 adults across three centers in France, including people with different levels of sensitivity and a contr…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods for IVF. Researchers looked at data from 333 people who had IVF between 2022 and 2023. The goal was to see if the AI's scores matched up with expert embryolo…

This completed study looked at over 3,000 adults having surgery to see which size of Macintosh blade (a tool used to guide a breathing tube into the windpipe) works best. The goal was to find out if blade size affects how often the tube goes in on the first try and how often seri…

This study looked at whether using a special freezing medium designed just for eggs, versus a universal medium for all stages, affects pregnancy rates in egg donation. Researchers analyzed data from 111 donor cycles. The goal is to see if the type of freezing medium makes a diffe…

This study looked at how common nerve damage is in adults who had vincristine chemotherapy for childhood leukemia. 467 survivors were assessed using a questionnaire about nerve symptoms. The goal was to understand how often and how severe this side effect is long after treatment …

This completed trial looked at 140 women who had their tubes tied (tubal ligation) to see if the surgical method affects sexual quality of life after 6 months. One group had standard abdominal laparoscopy, the other had a newer vaginal approach called vNOTES. Participants filled …

This completed study tested whether augmented reality (AR) can help surgeons during laparoscopic surgery for uterine fibroids or adenomyosis. AR overlays images from pre-surgery scans onto the live video feed, potentially making it easier to see and remove benign tumors. Forty pa…

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg supply. Researchers measured a hormone called AMH in blood samples from over 800 women with MS or a related condition. The goal was to see if disease activity or medications impact ovaria…