University Hospital, Clermont-ferrand

This trial tests whether giving teenagers with peanut allergy gradually increasing amounts of peanut protein can help them build tolerance. The goal is to see if they can safely eat a cumulative dose of 2 grams of peanut without an allergic reaction. The study also looks at wheth…

This trial tests whether giving a continuous infusion of noradrenaline during high-risk surgery can prevent dangerous drops in blood pressure, compared to the standard approach of treating low blood pressure only when it occurs. The study includes 300 adults aged 50 and older und…

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This trial tests whether adding hypotaurine, a natural antioxidant, to the media used for sperm preparation and freezing can protect sperm DNA from damage. The study compares sperm samples from 33 participants, processed with or without hypotaurine, through a freeze-thaw cycle. R…

This trial tests whether a 12-week program of eccentric cycling—where muscles lengthen under load, like pedaling against resistance—can reduce body fat in overweight and obese teenagers more effectively than traditional concentric cycling. The study compares both types of exercis…

This trial compares two types of surgical tools used during total hip replacement: single-use (disposable) reaming instruments and conventional reusable ones. The main focus is on the overall cost of surgery, including sterilization, materials, and operating room time. Researcher…

This trial tests whether injecting bone cement into a recently fractured vertebra (vertebroplasty) reduces disability better than wearing a brace. Adults aged 18–70 with a traumatic spinal fracture (within 15 days) are randomly assigned to one of the two treatments. The study mea…

This trial tests whether a high dose of curcumin, the active compound in turmeric, can improve the function of blood vessels in healthy middle-aged smokers. Participants aged 50 to 70 who smoke will receive curcumin, and researchers will measure changes in how well their blood ve…

This trial tests two types of intravenous fluids given during abdominal surgery: a standard saline solution and a starch-based fluid. The goal is to see whether one leads to fewer serious complications, such as kidney problems, breathing issues, heart failure, infections, or the …

This trial tests whether low-frequency deep brain stimulation can improve conscious behavior in people who have been in a vegetative or minimally conscious state for at least six months after a stroke or one year after a brain injury. Participants receive an implanted neurostimul…

This trial compares two modes of noninvasive ventilation in adults with acute respiratory failure: standard pressure support (PSV) and a newer mode called Neurally Adjusted Ventilatory Assist (NAVA). NAVA uses electrical signals from the diaphragm to trigger breathing support, wh…

This trial tests whether a single yogurt drink made from vegetable proteins rich in leucine, cysteine, and arginine can improve blood vessel function and reduce inflammation in older adults with cardiometabolic risk. Participants, aged 65 and older, will consume either the vegeta…

This trial tests whether a smartphone app called 'Mon coach dos' can help people with chronic low back pain stay committed to a physical exercise program. Participants receive either standard rehabilitation care or standard care plus training on using the app, which provides exer…

This trial tests whether the type of physical activity—resistance, endurance, or a mix—combined with a low-calorie diet can reduce belly fat and cardiovascular risk in people with metabolic syndrome. Adults aged 50-70 with metabolic syndrome are randomly assigned to one of three …

This trial tests whether doing a short bout of exercise right before or right after a meal changes how much adolescents with obesity eat and how hungry they feel. Teens aged 12-16 will either rest or exercise at specific times, then eat a buffet meal where their intake is measure…

This trial compares two techniques for guiding botulinum toxin injections to treat leg spasticity after a stroke: ultrasound and electrostimulation. The goal is to see which method improves ankle flexibility and reduces pain during the procedure. Adults with stroke-related spasti…

This trial tests whether epidural analgesia—pain medicine delivered near the spinal cord—can help people with severe acute pancreatitis breathe better and avoid needing a breathing machine. About 148 ICU patients with severe pancreatitis will be randomly assigned to receive eithe…

This trial tests whether giving a single dose of cyclosporine A to deceased organ donors before their kidneys are removed can reduce the chance of delayed graft function in recipients. Delayed graft function means the kidney does not start working right away, often requiring dial…

This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as …

This trial asks whether the amount of daily energy turnover—how much energy is used through diet and exercise—can influence appetite and food reward in adolescents with obesity. Eighteen teens aged 12-16 will each complete three sessions with low, moderate, or high energy turnove…

This trial tests whether taking polyphenol supplements with a meal can reduce how much iron the body absorbs in people with iron overload disorders like genetic hemochromatosis and dysmetabolic iron overload syndrome. Participants eat a standardized iron-rich meal with either pol…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

Newborns in intensive care often receive multiple intravenous treatments, and the hidden fluid from these infusions can build up, raising the risk of complications. This study tests a new care protocol designed to reduce that hidden fluid intake. Researchers will compare fluid vo…

This trial tests a decision-making tool designed to help ICU staff decide when to use physical restraints. The tool uses objective measures of a patient's mental state and equipment needs, along with family involvement. The goal is to reduce the use of restraints and related inci…

This study tested whether using lung CT images to guide ventilator settings could reduce deaths in people with ARDS. 420 adults were assigned to either standard ventilator care or a strategy based on their lung morphology. The goal was to see if personalized ventilation could imp…

This study tested whether using a lung ultrasound score to decide on breathing support (high-flow nasal oxygen or noninvasive ventilation) after removing a breathing tube could reduce breathing distress in ICU patients. 483 adults who had been on a ventilator for more than 48 hou…

This study tested whether inhaling sevoflurane, a gas usually used for anesthesia, for the first 48 hours could improve oxygen levels and reduce inflammation in 50 adults with moderate to severe ARDS. Participants were randomly assigned to receive either sevoflurane or a standard…

This study tested two different ways of using a breathing machine during emergency abdominal surgery. One method used higher air pressure to keep the lungs open, while the other used lower pressure to avoid overstretching the lungs. The goal was to see which approach led to fewer…

This study tested whether using sevoflurane (an inhaled anesthetic) for sedation could lower death rates and shorten time on a ventilator in patients with acute respiratory distress syndrome (ARDS). 700 adults were randomly assigned to receive either sevoflurane or standard propo…

This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiaz…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This trial tests whether a green dye, injected during keyhole surgery to remove benign ovarian cysts, can show how well the ovary is still getting blood flow. The idea is that better blood flow might mean the ovary is healthier and more likely to support a future pregnancy. Women…

This trial tests whether a new CT image-reconstruction algorithm called Veo can detect asbestos-related lung and pleural changes as accurately as the standard method, while delivering a much lower radiation dose. The study involves 90 workers previously exposed to asbestos, who w…

This trial tests whether the Icare200, a handheld rebound tonometer, measures eye pressure as accurately as the Goldmann applanation tonometer, the current gold standard. Adults needing eye-pressure checks will have their pressure measured with both devices, plus an air-puff tono…

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could sa…

This study tested a new combination test called Premaquick, which measures three markers in vaginal fluid, to see if it can better predict whether a woman with threatened preterm labor will deliver within 7 days. Researchers compared it to the standard fetal fibronectin test in 2…

This trial tests whether memantine, a drug used for Alzheimer's disease, can prevent the chronic nerve pain that sometimes develops after breast cancer surgery. Half of the participants receive memantine for four weeks, starting two weeks before their operation, while the other h…

This trial tests whether drinking grapefruit juice regularly over a long period can improve blood vessel function and bone health in healthy postmenopausal women. The study uses a crossover design, where each participant experiences both the juice and a control period, to isolate…

This trial asks whether giving patients a steady stream of warm, moist oxygen through a nasal tube right after abdominal surgery can prevent low blood oxygen levels, a common and serious complication. It enrolls adults at intermediate to high risk of lung problems who are having …

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested whether curcumin, the active ingredient in turmeric, can prevent Crohn's disease from coming back after surgery. 61 adults who had recent surgery for Crohn's were given either curcumin or a placebo, along with standard thiopurine drugs, for 6 months. The goal wa…

This study tested whether adding an oral antibiotic (ornidazole) the day before colorectal surgery to the standard IV antibiotic given at incision time could reduce surgical site infections within 30 days. Over 900 adults having elective colorectal surgery took part. The goal was…

This phase 3 trial tests whether a single dose of dexamethasone, pregabalin, or both can reduce pain during the first movement after lumbar disc surgery. Adults aged 18 to 85 undergoing this surgery may receive one of these treatments, and their pain will be tracked for 48 hours.…

This trial tests whether giving patients an educational booklet before total knee replacement surgery improves their knowledge and beliefs about the procedure. Adults aged 55 to 75 scheduled for knee replacement will receive the booklet or standard care. Researchers will measure …

This trial tests whether placing thin catheters alongside the breastbone before a heart surgery incision and delivering the numbing drug ropivacaine can reduce pain after the operation. Adults under 85 having planned heart surgery through a sternotomy may receive this continuous …

This trial tests whether practicing tai chi can increase overall physical activity in people with spondyloarthritis, a type of inflammatory arthritis. Participants will either take tai chi sessions for two or four months or receive no tai chi (control group). The study measures c…

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This trial tests whether intensive robot-assisted gait training can improve walking in children with hemiplegia, a form of cerebral palsy affecting one side of the body. Children aged 4 to 18 will receive either robot-assisted sessions with the G-EO system or standard physiothera…

This trial tests whether giving a steroid injection just before surgery for a broken leg can reduce swelling and pain compared to a placebo. Adults with certain leg fractures who need surgery within 72 hours are randomly assigned to receive either the steroid or a saline injectio…

This trial tests whether a 125 mg paracetamol tablet that dissolves in the mouth can relieve acute pain as effectively as a 1 g intravenous (IV) infusion. Adults aged 18 to 60 with moderate pain from minor limb injuries in the emergency room will be randomly assigned to one of th…

This trial tests whether taking magnesium can reduce stress in people with fibromyalgia, a condition marked by widespread pain and fatigue. Participants will be randomly assigned to receive magnesium or a placebo, and researchers will measure stress levels along with pain, sleep,…

This trial tests whether adding a double nerve block (femoral and sciatic) before general anesthesia can reduce pain and morphine use after femoropopliteal bypass surgery in people with peripheral arterial disease. The block, using levobupivacaine and clonidine, may also widen bl…

This trial tests whether a single session of hamstring stretching can immediately improve flexibility and reduce disability in people with chronic low back pain. Adults aged 18 to 60 with tight hamstrings and back pain lasting over three months will receive a one-minute stretch o…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This trial tests whether adding a self-management education program to a three-week spa treatment can increase physical activity levels in people with knee osteoarthritis. The program includes educational workshops and a written booklet, and the study will measure physical activi…

This study tests whether a daily supplement containing magnesium, B vitamins, rhodiola, and L-theanine can reduce stress in adults who report feeling stressed. Participants take either the supplement or a placebo for 28 days, and researchers measure stress through questionnaires,…

This trial tests whether a special liquid nutrition formula, enriched with arginine, omega-3 fatty acids, and nucleotides, can reduce the frequency and severity of mouth sores (mucositis) in patients with head and neck or esophageal cancer undergoing chemoradiotherapy. Participan…

This study looked at whether sophrology, a relaxation method using breathing, muscle relaxation, and mental imagery, can help lower stress. Researchers followed 60 adults—some who practiced sophrology weekly and some who did not—for several months. They measured stress using both…

This study tested whether the sedative dexmedetomidine can reduce how long non-intubated ICU patients experience agitated delirium. Researchers randomly gave 168 patients either dexmedetomidine or a placebo. The goal was to see if the drug shortens agitation and delirium, and red…

This study tested whether wearing a virtual reality mask during blood draws and allergy skin tests helps children aged 7 to 13 feel less pain and anxiety. About 300 kids from two hospitals took part. The goal was to see if distracting them with VR makes these procedures easier to…

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested whether ethosuximide, a drug used for epilepsy, can reduce belly pain in people with irritable bowel syndrome (IBS). 162 adults with IBS took either the drug or a placebo. The goal was to see if the drug could lower pain and improve quality of life.

This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadr…

This study tested whether ethosuximide, a drug already used for epilepsy, can reduce pain in people with nerve damage. 114 adults with peripheral neuropathic pain took either the drug or a placebo for 42 days. Researchers measured pain levels and quality of life to see if the dru…

This study tested whether botulinum toxin (Botox) injections can reduce head shaking in people with essential head tremor, a condition that often doesn't respond to standard medicines or surgery. About 120 adults with troublesome head tremor received either Botox or a placebo sho…

This study compared two surgical techniques for removing the uterus (hysterectomy) due to non-cancerous conditions: the newer vNOTES method (done through the vagina) and standard laparoscopy (keyhole surgery). 145 women took part, and researchers tracked complications, pain, and …

This study tested whether adding virtual reality (VR) to standard smoking cessation treatment helps people quit. 74 smokers who wanted to stop received nicotine patches and either usual counseling or VR-enhanced therapy. The goal was to see if VR could reduce cravings and improve…

This study looked at two different surgical methods for replacing the shoulder joint in people over 65 who had a severe shoulder fracture. The goal was to see which approach leads to better shoulder function, safety, and quality of life. 90 participants were randomly assigned to …

This study looked at 80 adults with a broken upper arm bone who needed surgery to place a metal nail inside the bone. Researchers compared the usual method (going through the rotator cuff) with a newer method (going through a gap called the rotator interval). The goal was to see …

This study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …

This study tested whether wearing a virtual reality headset during botulinum toxin injections could lower stress and pain in adults with muscle spasticity. Forty-two participants chose calming audio-visual content while getting their shots. Researchers measured heart rate variabi…

This trial tests whether a smartphone app called e-DOL can help doctors and patients track chronic pain over time. The app lets patients record pain levels, anxiety, and sleep quality, while doctors view the data on a web platform. The study includes adults with chronic pain who …

This study looks at whether chronic neuropathic pain and the medications used to treat it—like antidepressants, antiepileptics, or opioids—are linked to changes in hormone levels. Researchers will compare hormone levels in 120 adults with chronic pain to healthy volunteers matche…

This trial investigates whether genetic differences influence how paracetamol relieves pain and how the body processes it. One hundred healthy men aged 18 to 30 will receive either paracetamol or a placebo in two separate sessions, and researchers will measure pain thresholds and…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated IC…

This study uses interviews to learn how adults with disabilities and complex health conditions experience their mouth, oral health, and how these affect daily life and social participation. The goal is to see if a standard framework, the International Classification of Functionin…

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This study aims to understand why muscle fatigue develops differently in prepubertal boys compared to adult men. Researchers will measure muscle strength and fatigue in the knee and ankle muscles of 50 healthy participants (boys aged 8-11 and men aged 18-35). By comparing these g…

This study compares three different methods for prescribing eyeglasses in people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. The goal is to see if the best method depends on the shape of the cornea, as measured by corneal topography. Res…

This study looks at patients receiving high-dose intravenous amoxicillin for serious bacterial infections. Researchers will measure drug levels in the blood during the first week to see how much they vary between patients and within the same patient. They will also check for side…

This study investigates whether heart rate variability (HRV) can detect stress in emergency physicians during their shifts. Researchers will monitor doctors' HRV during day and night shifts and compare reactions to stressful events. The goal is to understand how expertise and hab…

This trial investigates how the body handles sevoflurane, an inhaled anesthetic used for short-term sedation, in burn patients in the intensive care unit (ICU). It compares drug levels in burn patients with those in other ICU patients to see if dosing needs adjustment. The study …

This study looks at whether lung and heart ultrasound can help predict if a patient in the intensive care unit (ICU) will successfully come off a breathing machine (ventilator). It follows 100 adults who have been on a ventilator for more than 48 hours and are ready for a weaning…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each…

This study aims to find out how many employees at a French furniture shop experience chronic pain, defined as pain rated above 3 out of 10. Researchers will use questionnaires to assess pain, anxiety, depression, quality of life, and how pain affects work. The goal is to better u…

This study looks at how psychological and social factors might help people living with HIV resist self-stigma—the negative feelings and beliefs they may hold about themselves due to their condition. Researchers will survey both patients and their healthcare providers to understan…

This study uses an online questionnaire to explore how people with past or active cancer in France use self-medication, including non-prescription drugs, herbal remedies, and supplements. It aims to understand what products they take, why, and where they get them. The findings co…

This trial investigates how different ways of creating an energy deficit affect appetite and food intake in adolescents with obesity. Participants will experience three conditions: exercise combined with dietary restriction, dietary restriction alone, and a rest control. Research…

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This early-phase trial in healthy men aged 18 to 45 asks whether taking N-acetylcysteine alongside acetaminophen (paracetamol) changes the drug's pain-relieving effect. Participants receive either the combination or a placebo, and researchers measure pain intensity from heat stim…

This study aims to find out which germs cause summer diarrhea in children who visit the emergency room. Researchers will collect stool samples from children aged 0 to 16 and test them for viruses, bacteria, and parasites. The goal is to better understand the causes of these infec…

This trial investigates whether gluten consumption affects digestive comfort, quality of life, and physical performance in non-celiac athletes who train intensively. Participants, who are healthy and free of digestive diseases, will be randomly assigned to a gluten-containing or …

This early-stage trial asks whether dextromethorphan, a common cough suppressant, can reduce heightened pain sensitivity in healthy adults. Participants receive both dextromethorphan and a placebo on separate occasions, and researchers measure pain thresholds in skin areas that b…

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study explores how weight-loss surgery changes the body's protein needs and whether fast-absorbing milk proteins can help preserve muscle mass and strength. Researchers will measure nitrogen balance and muscle function in 25 adults with severe obesity before and after gastri…

This study follows people with relapsing-remitting multiple sclerosis who are starting immunosuppressant treatment. Researchers will track changes in cognitive abilities, fatigue, emotions, and overall quality of life over an extended period. The goal is to better understand how …

This study investigates whether genetic differences and altered pain processing contribute to fibromyalgia, a condition marked by widespread pain and increased sensitivity to painful stimuli. Researchers will compare 260 adults with fibromyalgia to a matched control group, measur…

This study looks at how the body's energy use changes during weight loss and regain in adolescents with obesity. Researchers will track resting and exercise energy expenditure, body composition, and food preferences in 40 teens aged 12-16 over a 12-month behavioral program. The g…

This trial asks whether the length of a shift affects stress levels in emergency physicians. Doctors will work either a 24-hour shift or a 14-hour night shift, and researchers will measure stress biomarkers like heart rate variability and stress hormones. They will also track per…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This trial asks whether bioimpedance analysis—a quick, painless way to measure body fluid—can be used safely in people with implanted heart devices like pacemakers and defibrillators. Current guidelines warn against it due to possible electromagnetic interference, but this has no…

This study looks at whether a single 30-minute cycling session can alter how adolescents with obesity experience hunger and food reward after a fixed meal. Researchers will measure appetite feelings, food preferences, and how much they eat at a later dinner. The goal is to unders…

This trial compares how burning calories through exercise versus cutting calories through diet affects appetite and food intake in adolescents with obesity. Participants (aged 12-16) will undergo both conditions—an exercise session and a dietary restriction—and their hunger, food…

This study looks at how often people who visit a community psychiatrist have had suicidal thoughts in the two weeks before their appointment. Researchers will ask about 262 adults to fill out questionnaires measuring suicidal risk, psychological pain, and self-esteem. The goal is…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This study investigates how aging and schizophrenia influence metamemory—the ability to judge one's own memory accuracy. Researchers will compare four groups: younger and older adults with schizophrenia, and younger and older healthy controls. Participants will rate their confide…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study looks at whether doing exercise 30 minutes versus 180 minutes before lunch changes how much adolescents with obesity eat at that meal. Participants, aged 12-16, will cycle at a moderate intensity at one of those times, then eat a buffet lunch where their intake is meas…

This study looks at what makes some women naturally lean without dieting or eating disorders. Researchers will compare eating habits, physical activity, body composition, and appetite responses in three groups: constitutionally lean women, normal-weight women, and women with anor…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study looks at how a 12-week weight loss program—combining nutrition advice, exercise, and psychological support—changes the way teenagers with obesity burn energy. Researchers want to understand the separate roles of metabolic and mechanical load on energy expenditure durin…

This study looks at how weight loss changes the way the body uses energy during exercise. Healthy normal-weight adults will either lose weight through diet or have their weight loss simulated using a special treadmill. The goal is to see if real weight loss affects exercise metab…

This study looks at how athletes who regularly lose and regain weight to meet competition categories experience changes in metabolism, body temperature, and body composition. Researchers will track 48 athletes through periods of weight maintenance, loss, and regain, using body te…

This study asks how often people seeking help for addiction have experienced or committed intimate partner violence. Researchers will use a questionnaire with 122 adults in France who are in or have been in a relationship. The goal is to understand these patients' experiences and…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This study looks at the gut bacteria of premature babies to see if differences exist between those who develop necrotizing enterocolitis (NEC) — a severe bowel condition — and those who do not. Researchers collect weekly blood and daily stool samples from about 300 premature infa…

This study looks at people with a rare inherited condition called dysfibrinogenemia, which affects how blood clots form. Researchers collected blood samples from 70 patients to analyze clot structure and search for genetic variations that might explain why some patients bleed whi…

This study looked at how a blend of plant and whey protein, combined with a 12-week exercise program, affects protein digestion and muscle health in 15 inactive older adults. Researchers measured how the body uses amino acids from meals and checked muscle tissue markers. The goal…

This study aimed to find simple ways to predict how much pain people will feel after oral surgery, like having a tooth pulled. Researchers measured things like pain sensitivity before the procedure in 148 adults. The goal was to create a model that helps doctors plan better pain …

This study tested whether a personalized approach to removing breathing tubes in the ICU works better than standard care. About 691 adults on ventilators for over 24 hours were included. Doctors used daily checks and chose the best method (T-piece or pressure support) based on ea…

This study looked at 332 stroke patients to see if general anesthesia or conscious sedation is better during a procedure to remove blood clots from the brain. The goal was to find which method leads to better recovery and fewer complications within the first week. The results cou…

This study looked at two ways of pushing during the final stage of labor: holding your breath while pushing (Valsalva) versus pushing while exhaling (open-glottis). Researchers wanted to see which method leads to fewer injuries and better outcomes for both mother and baby. A tota…

This study of 60 people with cirrhosis measured quadriceps (thigh) strength and compared it to standard frailty and malnutrition scores. The goal was to see if a simple leg strength test could replace more complex frailty assessments. No treatment was given; it was purely an obse…

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire, which measures how oral health affects daily life. Researchers enrolled 200 French-speaking adults, including people with gum disease and healthy controls. Participants filled out the quest…

This study tests a French version of a questionnaire that measures how dentin hypersensitivity (sharp, brief tooth pain) affects people's daily lives. Researchers enrolled 216 adults across three centers in France, including people with different levels of sensitivity and a contr…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods for IVF. Researchers looked at data from 333 people who had IVF between 2022 and 2023. The goal was to see if the AI's scores matched up with expert embryolo…

This completed study looked at over 3,000 adults having surgery to see which size of Macintosh blade (a tool used to guide a breathing tube into the windpipe) works best. The goal was to find out if blade size affects how often the tube goes in on the first try and how often seri…

This study looked at whether using a special freezing medium designed just for eggs, versus a universal medium for all stages, affects pregnancy rates in egg donation. Researchers analyzed data from 111 donor cycles. The goal is to see if the type of freezing medium makes a diffe…

This study looked at how common nerve damage is in adults who had vincristine chemotherapy for childhood leukemia. 467 survivors were assessed using a questionnaire about nerve symptoms. The goal was to understand how often and how severe this side effect is long after treatment …

This completed trial looked at 140 women who had their tubes tied (tubal ligation) to see if the surgical method affects sexual quality of life after 6 months. One group had standard abdominal laparoscopy, the other had a newer vaginal approach called vNOTES. Participants filled …

This completed study tested whether augmented reality (AR) can help surgeons during laparoscopic surgery for uterine fibroids or adenomyosis. AR overlays images from pre-surgery scans onto the live video feed, potentially making it easier to see and remove benign tumors. Forty pa…

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg supply. Researchers measured a hormone called AMH in blood samples from over 800 women with MS or a related condition. The goal was to see if disease activity or medications impact ovaria…