University Hospital, Clermont-ferrand

This study tested whether using a CT scan to guide breathing machine settings could lower the death rate in people with ARDS, a severe lung injury. 420 adults were split into two groups: one received standard care, and the other had settings based on their lung CT pattern. The ma…

This study looked at whether a sedation drug called sevoflurane, given as a gas to breathe, could help people with severe lung injury (ARDS) live longer and need a breathing machine for fewer days. About 700 adults were randomly assigned to receive either sevoflurane or the stand…

This study compared two ways of using a breathing machine during emergency abdominal surgery to see which one leads to fewer lung problems and deaths. Over 700 adults took part. One method used higher air pressure and extra breaths to open the lungs, while the other used lower pr…

This study looked at whether giving a gas called sevoflurane (used for sleep during surgery) for 48 hours can improve oxygen levels and reduce inflammation in people with acute respiratory distress syndrome (ARDS), a severe lung condition. Fifty adults with moderate to severe ARD…

This study tested whether a structured plan for giving diuretics (water pills) to patients hospitalized with worsening chronic heart failure is safer and more effective than usual care. About 299 adults took part. The goal was to see if the protocol helped patients lose excess fl…

This study looked at whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury really needs a CT scan. CT scans use radiation, which can slightly increase the risk of brain tumors in children. The study involved over 2,200 ch…

This study tested a new diagnostic tool called Premaquick, which measures three markers in vaginal fluid, to see if it can better predict whether a woman with threatened preterm labor will deliver within 7 days. Researchers compared it to the standard fetal fibronectin test in 22…

This study tested whether taking an oral antibiotic the day before colorectal surgery, in addition to the standard IV antibiotic given at incision, reduces surgical site infections. Over 900 adults having elective colorectal surgery took part. The goal was to see if the combined …

This study tested whether a single infusion of ketamine combined with magnesium can reduce the number of daily attacks in people with chronic cluster headache that hasn't responded to standard treatments. 93 adults with at least 2 attacks per day received either the ketamine-magn…

This study tested whether botulinum toxin (Botox) injections can reduce head shaking in people with essential head tremor. 120 adults received either Botox or a placebo injection. The goal was to see if the treatment improved tremor and quality of life. Results may offer a new op…

This study looked at whether a specific type of strength training (eccentric isokinetic exercises) is better than standard exercises for people with knee osteoarthritis. Forty adults aged 40-70 with one-sided knee arthritis participated. The goal was to see if this exercise could…

This study tested whether a smartphone app (ARTHE-e) helps people with knee osteoarthritis follow their exercise plan better than standard care. About 120 adults aged 40-85 with knee osteoarthritis participated. The app provides guidance and reminders to keep users on track with …

This study tested whether ethosuximide, a low-cost seizure medication, can reduce pain and improve quality of life in adults with peripheral nerve pain caused by injury or surgery. About 114 participants received either the drug or a placebo for 43 days. The goal was to see if bl…

This study tested whether a drug called dexmedetomidine can reduce how long ICU patients feel agitated and confused (delirium). The study included 168 adults in the ICU who were not on breathing machines. Researchers measured how long agitation and delirium lasted, and whether pa…

This small study looked at 7 adults with long-term nerve pain (neuropathic pain) who had already gotten relief from ketamine. Researchers wanted to see if taking memantine or dextromethorphan after ketamine could help maintain or improve pain control. The goal was to find a pract…

This study tested whether wearing a virtual reality mask during blood draws and skin prick tests can reduce pain and anxiety in allergic children aged 7 to 13. 300 kids from two hospitals took part. The goal was to see if distracting them with VR makes these procedures easier.

This study tested whether a virtual reality program could help people quit smoking. 74 smokers who wanted to quit used a VR program designed to handle high-risk relapse situations. Researchers measured how many quit after 6 weeks and up to a year, and tracked cravings and daily c…

This study tested whether using virtual reality during botulinum toxin injections could lower stress in people with muscle stiffness from conditions like stroke or multiple sclerosis. 42 adults received injections while either using VR or not. Researchers measured stress through …

This study looked at 80 people with a broken upper arm bone who needed surgery with a metal nail. Researchers compared the usual method of inserting the nail through the rotator cuff versus a new method through a natural gap in the shoulder. The goal was to see which approach hel…

This study tested whether ethosuximide, a drug usually used for seizures, can reduce belly pain in people with irritable bowel syndrome (IBS). About 162 adults with IBS and moderate-to-severe pain took part. The goal was to see if the drug lowers pain and improves quality of life…

This study looked at two different ways to perform shoulder replacement surgery in people over 65 who had a severe shoulder fracture. The goal was to see which surgical approach leads to better shoulder function and recovery. 90 patients took part, and their progress was measured…

This study compared two ways to remove the uterus for non-cancerous reasons: a newer method called vNOTES (done through the vagina) and standard laparoscopic surgery (keyhole). 145 women took part, and researchers tracked complications like bleeding or infection, as well as pain …

This study looked at 148 adults having teeth pulled to find out which simple, pre-surgery clues can predict how much pain they will feel afterward. Researchers tested a pain sensitivity questionnaire and other easy-to-measure traits. The goal is to help dentists personalize pain …

This study looked at over 3,000 adults having surgery to see which size of Macintosh blade (a tool used to help place a breathing tube) works best on the first try. The goal was to find the most effective blade size to reduce complications like low oxygen or low blood pressure. R…

This study tested whether augmented reality (AR) can help surgeons during laparoscopic surgery for benign uterine tumors like fibroids. Forty patients took part, and surgeons used a special AR device to overlay images from scans onto the live video feed. The main goal was to see …

This study looked at 60 adults with cirrhosis to see if a simple frailty test (Liver Frailty Index) matches actual leg muscle strength. Researchers measured quadriceps strength and checked for malnutrition and frailty using several tools. The goal is to find better ways to spot p…

This study looked at 332 people having a procedure to remove a blood clot from the brain after a stroke. Researchers wanted to see if using sedation (keeping the patient sleepy but breathing on their own) or general anesthesia (being fully asleep with a breathing tube) led to bet…

This study looked at 140 women who had their tubes tied (tubal ligation) to see if the way the surgery was done affected their sex life. One group had standard belly-button laparoscopy, the other had a newer method through the vagina (vNOTES). The main goal was to compare sexual …

This study looked at whether the type of freezing solution used for donated eggs affects pregnancy rates. Researchers compared a solution made just for eggs to a universal one that works for all stages. They studied 111 couples receiving donated eggs and found no major difference…

This study tested a new approach using a lung ultrasound score to guide treatment decisions after removing a breathing tube in ICU patients who were on a ventilator for more than 48 hours. The goal was to see if this method could reduce the number of patients who develop serious …

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg supply, measured by a hormone called AMH. Researchers analyzed blood samples from over 800 women with MS or a related condition, aged 18 to 35. The goal was to help doctors decide when to…

This study tested whether a personalized strategy for removing breathing tubes (weaning) from intensive care unit patients works better than usual care. The approach used daily checks and chose the best method based on each patient's risk factors, like obesity or heart disease. T…

This study looked at long-term nerve damage in 467 adults who had childhood leukemia and were treated with vincristine. Researchers used a questionnaire to measure how common and severe the nerve problems were. The goal was to better understand the lasting side effects of this ch…

This study tested an artificial intelligence system called EMA to see if it can rank embryos better than traditional methods used in IVF. Researchers compared AI scores with manual embryo grading from 333 IVF cycles. The goal was to find out if AI can more accurately predict whic…

This study checks if a French version of the Dentine Hypersensitivity Experience Questionnaire (DHEQ-fr) works correctly. Dentin hypersensitivity causes brief, sharp tooth pain, and this questionnaire helps measure how it affects quality of life. Researchers tested 216 adults acr…

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire in 200 adults, including people with gum disease and healthy volunteers. The goal was to ensure the questionnaire accurately measures how oral health affects quality of life. Participants si…

This study looked at two different ways of pushing during the final stage of labor: holding your breath while pushing (closed-glottis) versus pushing while breathing out (open-glottis). Researchers wanted to see which method leads to fewer injuries and better outcomes for both mo…