Can your DNA predict how well paracetamol works?
NCT ID NCT01520792
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial investigates whether genetic differences influence how paracetamol relieves pain and how the body processes it. One hundred healthy men aged 18 to 30 will receive either paracetamol or a placebo in two separate sessions, and researchers will measure pain thresholds and blood markers. The goal is to understand why pain relief from paracetamol varies so much between individuals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- paracetamol (acetaminophen)
- What this could lead to
- If successful, this could help explain why paracetamol works differently for different people and may guide more personalized pain relief.
- What could go wrong
- This is an early-phase study in a small, specific group (healthy young men), so results may not apply to the general population or to people with pain conditions.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
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