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Why weight loss stalls: study probes energy shifts in teens

NCT ID NCT06085040

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study looks at how the body's energy use changes during weight loss and regain in adolescents with obesity. Researchers will track resting and exercise energy expenditure, body composition, and food preferences in 40 teens aged 12-16 over a 12-month behavioral program. The goal is to understand why weight regain often happens and how the degree of weight loss affects these metabolic adaptations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
multidisciplinary behavioral intervention combining physical activity, nutritional guidance, and psychological support
What this could lead to
If successful, this research could identify key stages where metabolic adaptations hinder weight maintenance, leading to more effective obesity treatments for adolescents.
What could go wrong
This is an observational study with only 40 participants, so findings may not apply broadly. It aims to understand mechanisms rather than test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Aug 2023

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 16 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects aged 12 to 16 years (maturation 3-5 according to Tanner stages), having a body mass index (BMI) greater than the 97th percentile according to national curves. * Able to give informed consent (parental authorization and assent of the minor) to participate in the research. * Person subject to a Social Security system Exclusion Criteria: * Medical or surgical history judged by the investigator to be incompatible with the study. * Presence of diabetes, and any other pathology limiting the application of one or the other strategy being tested. * Subjects currently undergoing energy restriction or a weight loss program through physical activity at the time of inclusion or during the last 6 months. * Taking medications that may interfere with study results * Subjects with cardiovascular problems, we are talking here about subjects with a history of cardiovascular and/or neurovascular pathology, as well as subjects presenting cardiovascular and/or neurovascular risk factors (excluding obesity/ overweight). * Surgical intervention within the previous 3 months. * Pregnant or breastfeeding adolescents * Person under guardianship/curatorship or safeguard of justice * Participant's refusal to participate * Refusal of consent (parental authorization) from holders of parental authority * Person in period of exclusion from another study * Consumption of tobacco or alcohol. * Parents under curatorship/tutorship or legal protection. * Special diet. * Participation in regular and intense physical and sporting activities for more than two hours per week. * Refusal of participation by legal representatives.

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Conditions

The condition(s) this trial relates to.

obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pediatric obesity

Contacts and locations

Locations

  • CHU Clermont-Ferrand

    Clermont-Ferrand, France, France

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