Why weight loss stalls: study probes energy shifts in teens

NCT ID NCT06085040

Completed Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study looks at how the body's energy use changes during weight loss and regain in adolescents with obesity. Researchers will track resting and exercise energy expenditure, body composition, and food preferences in 40 teens aged 12-16 over a 12-month behavioral program. The goal is to understand why weight regain often happens and how the degree of weight loss affects these metabolic adaptations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: multidisciplinary behavioral intervention combining physical activity, nutritional guidance, and psychological support
What this could lead to: If successful, this research could identify key stages where metabolic adaptations hinder weight maintenance, leading to more effective obesity treatments for adolescents.
What could go wrong: This is an observational study with only 40 participants, so findings may not apply broadly. It aims to understand mechanisms rather than test a new treatment.

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Conditions

The condition(s) this trial relates to.

Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC OBESITY

Contacts and locations

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Locations

CHU Clermont-Ferrand

Clermont-Ferrand, France, France

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