Could a single dose of two common drugs tame Post-Surgery back pain?
NCT ID NCT01811251
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether a single dose of dexamethasone, pregabalin, or both can reduce pain during the first movement after lumbar disc surgery. Adults aged 18 to 85 undergoing this surgery may receive one of these treatments, and their pain will be tracked for 48 hours. The goal is to find a simple, low-cost way to improve pain control and reduce the need for stronger opioids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A single dose of dexamethasone, pregabalin, or a combination of both, given before or during lumbar disc surgery to reduce postoperative pain.
- What this could lead to
- If effective, this could establish a simple, inexpensive pain management protocol that reduces the need for morphine and improves recovery after back surgery.
- What could go wrong
- The trial is relatively small and focuses on short-term pain relief. Results may not apply to all patients, and the drugs carry risks like nausea, dizziness, or increased blood sugar.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France